O-Benzoyl pyridine aldoxime and amidoxime derivatives: novel efficient DNA photo-cleavage agents
作者:Paraskevi Karamtzioti、Asterios Papastergiou、John G. Stefanakis、Alexandros E. Koumbis、Ioanna Anastasiou、Maria Koffa、Konstantina C. Fylaktakidou
DOI:10.1039/c4md00548a
日期:——
Pyridine oxime esters are effective DNA photocleavers, causing single-/double-stranded DNA cleavage at concentrations as low as 1 μM.
吡啶羟肟酯是有效的DNA光解剂,在浓度低至1μM时可引起单链/双链DNA的裂解。
Antimycobacterial Activity of Substituted Isosteres of Pyridine- and Pyrazinecarboxylic Acids. 2.
作者:Mikail H. Gezginci、Arnold R. Martin、Scott G. Franzblau
DOI:10.1021/jm000350w
日期:2001.5.1
included in this study due to their interesting activity. Pivaloyloxymethyl derivatives of the isosteres were also prepared in order to increase their lipophilicity and therefore improve their cellular permeability. The derivatized isosteres were expected to be biotransformed by esterases to the active species after penetration of the mycobacterial cell wall. Biological properties of the compounds were compared