4-methyl-1-p-tolyl-pent-1-en-3-one | 67962-11-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-1-p-tolyl-pent-1-en-3-one
• 英文别名: trans-4-Methyl-1-p-tolyl-pent-1-en-3-one；(E)-4-methyl-1-(4-methylphenyl)pent-1-en-3-one
• CAS: 67962-11-2
• 化学式: C₁₃H₁₆O
• 分子量: 188.269
• InChiKey: JQTJAMXNMIMRDL-CMDGGOBGSA-N

物化性质

• 沸点：
  305.5±11.0 °C(Predicted)
• 密度：
  0.971±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-methyl-1-p-tolyl-pent-1-en-3-one 以 甲醇 为溶剂， 生成 trans-4-methyl-1-p-tolyl-1-penten-3-ol
  参考文献：
  名称：

  RXR activating molecules

  摘要：

  本发明涉及可以激活RXR受体的分子，其中所述分子包括与RXR受体结合的RXR结合部分，包括与RXR受体的侧袋1接触的侧袋接触残基。

  公开号：

  US20030105333A1
• 作为产物：
  描述：

  3-甲基-2-丁酮 、 对甲基苯甲醛 在 sodium hydroxide 作用下， 以 水 为溶剂， 生成 4-methyl-1-p-tolyl-pent-1-en-3-one
  参考文献：
  名称：

  Evaluation of some thiosemicarbazones of arylidene ketones and analogues for anticonvulsant activities

  摘要：

  DOI：

  10.1016/0223-5234(90)90182-3

文献信息

• Substituted dihydronaphthalene and isochroman compounds for the treatment of metabolic disorders, cancer and other diseases
  申请人：Tachdjian Catherine

  公开号：US20050038098A1

  公开（公告）日：2005-02-17

  The invention relates to novel heterocyclic compounds having the structure illustrated by Formula (I) wherein the Ar 1 radicals are substituted dihydronapthalene or isochroman radicals, the Ar 2 radicals are aryl or heteroaryl radicals; and HAr is a 2,4-thiazolidinedione, 2-thioxo-thiazolidine-4-one, 2,4-imidazolidinedione or 2-thioxo-imidazolidine-4-one radical. The compounds of Formula (I) can have biological activity for advantageously regulating carbohydrate metabolism, including serum glucose level, and lipid metabolism, and can be useful for the treatment of hyperlipidemia and/or hypercholesterolemia, and Type II diabetes. The compounds of Formula (I) can also have utility in the treatment of diseases of uncontrolled proliferation, including cancer.

  本发明涉及具有公式（I）所示结构的新型杂环化合物，其中Ar1基团是取代的二氢萘或异色满基团，Ar2基团是芳基或杂环芳基基团；HAr是2,4-噻唑烷二酮，2-硫代噻唑烷-4-酮，2,4-咪唑烷二酮或2-硫代咪唑烷-4-酮基团。公式（I）的化合物可以具有生物活性，有利于调节碳水化合物代谢，包括血清葡萄糖水平和脂质代谢，并可用于治疗高脂血症和/或高胆固醇血症以及II型糖尿病。公式（I）的化合物还可用于治疗不受控制增殖的疾病，包括癌症。
• 1-SUBSTITUTED, 4-(SUBSTITUTED PHENOXYMETHYL)-1,2,3-TRIAZOLE COMPOUNDS WITH ANTIFUNGAL PROPERTIES AND METHODS FOR PREPARATION THEREOF
  申请人：FDC LIMITED

  公开号：US20160009692A1

  公开（公告）日：2016-01-14

  Disclosed herein are novel antifungal compounds of Formula 1, containing 1-substituted, 4-(substituted phenoxy-methyl)-1,2,3-triazole moieties coupled to a core having triazole ring, (un)substituted phenyl ring and tertiary alcoholic functionality, and pharmaceutically acceptable salts thereof; methods for preparing these compounds; and pharmaceutical preparations containing these novel compounds for prevention and treatment of fungal infections.

  本文披露了一种新型的抗真菌化合物，式子为1，包含1-取代，4-(取代苯氧甲基)-1,2,3-三唑基团偶联到具有三唑环、(未)取代苯环和三级醇功能的核心上，以及其药学上可接受的盐；制备这些化合物的方法；和含有这些新型化合物的药物制剂，用于预防和治疗真菌感染。
• Iridium-catalysed desilylative acylation of 1-alkenylsilanes
  作者：Maciej Zaranek、Maciej Skrodzki、Justyna Szudkowska-Frątczak、Maciej Dodot、Ireneusz Kownacki、Bartosz Orwat、Piotr Pawluć

  DOI：10.1016/j.molcata.2016.10.035

  日期：2017.1

  We report the iridium-catalysed desilylative acylation of styryl and dienyl silanes by acid anhydrides to afford (E)-alpha,beta-unsaturated ketones. The [Ir(mu-Cl)(cod)}(2)] catalyst is the first non-rhodium complex successfully applied for this type of transformation. Stoichiometric reaction of [Ir(mu-Cl)(cod)}(2)] with (E)-trimethyl(4-chlorostyryl)silane was carried out to gain insight into the reaction mechanism. (C) 2016 Elsevier B.V. All rights reserved.
• An Improved Procedure for the Claisen-Schmidt Reaction
  作者：J. V. Sinisterra、A. Garcia-Raso、J. A. Cabello、J. M. Marinas

  DOI：10.1055/s-1984-30882

  日期：——
• Dimmock; Kumar; Allen, Pharmazie, 1997, vol. 52, # 3, p. 182 - 186
  作者：Dimmock、Kumar、Allen、Kao、Halleran、Balzarini、De Clercq

  DOI：——

  日期：——