2-Aminomethylpyridine acetate | 111608-95-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Aminomethylpyridine acetate
• 英文别名: Acetic acid;pyridin-2-ylmethanamine；acetic acid;pyridin-2-ylmethanamine
• CAS: 111608-95-8
• 化学式: C₂H₄O₂*C₆H₈N₂
• 分子量: 168.195
• InChiKey: DTTSYJJACPMDMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.63
• 重原子数：
  12.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  76.21
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  2-氰基吡啶 在 palladium on activated charcoal 氢气 作用下， 以 溶剂黄146 为溶剂， 反应 0.5h， 以90%的产率得到2-Aminomethylpyridine acetate
  参考文献：
  名称：

  2-氨基甲基-1,10-菲咯啉的合成。一种新型螯合剂和用于其他螯合化合物的通用合成子

  摘要：

  描述了由1,10-菲咯啉（1）合成2-氨基甲基-1,10-菲咯啉（4）。在温和的反应条件下，在乙酸中含10％钯碳的情况下，将2-氰基-1,10-菲咯啉（3）还原为4也是一种非常有效的方法，用于将氰基吡啶转化为甲基氨基吡啶。

  DOI：

  10.1002/jhet.5570230403

文献信息

• COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS
  申请人：Lantheus Medical Imaging, Inc.

  公开号：US20150196672A1

  公开（公告）日：2015-07-16

  The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

  本发明提供了具有成像基团的化合物，用于对受试者进行成像。本发明还涉及用于合成和使用成像试剂或其前体的系统、组合物和方法。成像试剂前体可以使用本文所述的方法转化为成像试剂。在某些情况下，组合物或多种成像试剂富集于 18 F。在某些情况下，成像试剂可用于成像受试者的感兴趣区域，包括但不限于心脏、心血管系统、心脏血管、大脑和其他器官。
• [EN] TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES, AND METHODS OF USE THEREOF<br/>[FR] COMPLEXES DE TECHNETIUM- ET RHENIUM-BIS(HETEROARYLE), ET LEURS PROCEDES D'UTILISATION
  申请人：MOLECULAR INSIGHT PHARM INC

  公开号：WO2005079865A1

  公开（公告）日：2005-09-01

  One aspect of the invention relates to complexes of a radionuclide with various heteroaryl ligands, e.g., imidazolyl and pyridyl ligands, and their use in radiopharmaceuticals for a variety of clinical diagnostic and therapeutic applications. Another aspect of the invention relates to imidazolyl and pyridyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the radionuclide complexes are also described. Another aspect of the invention relates to imidazolyl and pyridyl ligands based on derivatized lysine, alanine and bis-amino acids for conjugation to small peptides by solid phase synthetic methods. Additionally, the invention relates to methods for imaging regions of a mammal using the complexes of the invention.

  该发明的一个方面涉及放射性核素与各种杂环芳基配体（例如咪唑基和吡啶基配体）形成的配合物，以及它们在临床诊断和治疗应用中的放射性药物中的使用。该发明的另一个方面涉及形成前述配合物一部分的咪唑基和吡啶基配体。还描述了制备放射性核素配合物的方法。该发明的另一个方面涉及基于衍生赖氨酸、丙氨酸和双氨基酸的咪唑基和吡啶基配体，用于通过固相合成方法与小肽结合。此外，该发明涉及使用该发明的配合物来成像哺乳动物体内区域的方法。
• Technetium-depyridine complexes, and methods of use thereof
  申请人：——

  公开号：US20030235843A1

  公开（公告）日：2003-12-25

  One aspect of the invention relates to novel complexes of technetium (Tc) with various heteroaromatic ligands, e.g., pyridyl and imidazolyl ligands, and their use in radiopharmaceuticals for a variety of clinical diagnostic and therapeutic applications. Another aspect of the invention relates to novel pyridyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the technetium complexes are also described. Another aspect of the invention relates to novel pyridyl ligands based on derivatized lysine, alanine and bis-amino acids for conjugation to small peptides by solid phase synthetic methods. Additionally, the invention relates to methods for imaging regions of a mammal using the complexes of the invention.

  该发明的一个方面涉及锝（Tc）与各种杂芳配体（例如吡啶基和咪唑基配体）形成的新型络合物，以及它们在临床诊断和治疗应用中的放射性药物的使用。该发明的另一个方面涉及构成上述络合物一部分的新型吡啶配体。还描述了制备锝络合物的方法。该发明的另一个方面涉及基于衍生赖氨酸、丙氨酸和双氨基酸的新型吡啶配体，用于通过固相合成方法与小肽结合。此外，该发明还涉及使用该发明的络合物对哺乳动物的某些区域进行成像的方法。
• Technetium- and rhenium-bis(heteroaryl) complexes, and methods of use thereof
  申请人：Babich W. John

  公开号：US20060034758A1

  公开（公告）日：2006-02-16

  One aspect of the invention relates to complexes of a radionuclide with various heteroaryl ligands, e.g., imidazolyl and pyridyl ligands, and their use in radiopharmaceuticals for a variety of clinical diagnostic and therapeutic applications. Another aspect of the invention relates to imidazolyl and pyridyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the radionuclide complexes are also described. Another aspect of the invention relates to imidazolyl and pyridyl ligands based on derivatized lysine, alanine and bis-amino acids for conjugation to small peptides by solid phase synthetic methods. Additionally, the invention relates to methods for imaging regions of a mammal using the complexes of the invention.

  本发明的一个方面涉及放射核素与各种杂环芳基配体的复合物，例如咪唑基和吡啶基配体，并将其用于多种临床诊断和治疗应用的放射性药物中。本发明的另一个方面涉及咪唑基和吡啶基配体，它们构成上述复合物的一部分。还描述了制备放射核素复合物的方法。本发明的另一个方面涉及基于衍生赖氨酸、丙氨酸和双胺基酸的咪唑基和吡啶基配体，以通过固相合成方法与小肽结合。此外，本发明还涉及使用本发明的复合物成像哺乳动物区域的方法。
• TECHNETIUM-DIPYRIDINE COMPLEXES, AND METHODS OF USE THEREOF
  申请人：Babich John W.

  公开号：US20090023787A1

  公开（公告）日：2009-01-22

  One aspect of the invention relates to novel complexes of technetium (Tc) with various heteroaromatic ligands, e.g., pyridyl and imidazolyl ligands, and their use in radiopharmaceuticals for a variety of clinical diagnostic and therapeutic applications. Another aspect of the invention relates to novel pyridyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the technetium complexes are also described. Another aspect of the invention relates to novel pyridyl ligands based on derivatized lysine, alanine and bis-amino acids for conjugation to small peptides by solid phase synthetic methods. Additionally, the invention relates to methods for imaging regions of a mammal using the complexes of the invention.

  本发明的一个方面涉及与各种杂环芳香族配体（例如吡啶基和咪唑基配体）形成的铼（Tc）的新型络合物，以及它们在临床诊断和治疗应用中的放射性药物中的使用。本发明的另一方面涉及形成前述络合物一部分的新型吡啶基配体。还描述了制备铼络合物的方法。本发明的另一方面涉及基于衍生的赖氨酸，丙氨酸和双氨基酸的新型吡啶基配体，以通过固相合成方法与小肽结合。此外，本发明涉及使用本发明的络合物对哺乳动物的区域进行成像的方法。