2,6-diazidopyridine | 1040488-20-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,6-diazidopyridine
• 英文别名: 2,6-Diazidopyridine
• CAS: 1040488-20-7
• 化学式: C₅H₃N₇
• 分子量: 161.126
• InChiKey: YZRDEMLDWVSUDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,6-diazidopyridine 在 盐酸 、 tetrakis(actonitrile)copper(I) hexafluorophosphate 、 三乙胺 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran 为溶剂， 反应 16.0h， 生成 1,1'-((1,1'-(pyridine-2,6-diyl)bis(1H-1,2,3-triazole-4,1-diyl))bis(methylene))bis(3-butylthiourea)
  参考文献：
  名称：

  Preorganization in bistriazolyl anion receptors

  摘要：

  A series of 4,6-bis-(1,2,3-triazolyl)-pyrimidine and 4,6-bis-(1,2,3-triazolyl)-pyridine anion receptors were synthesized and the effect of the pyrimidine and pyridine moieties on their binding properties was examined. We found that intramolecular interactions preorganize the 4,6-bis-(1,2,3-triazolyl)-pyridine receptors resulting in higher anion binding constants in comparison with the nonpreorganized 4,6-bis-(1,2,3-triazolyl)-pyrimidine receptor. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.05.133
• 作为产物：
  描述：

  2,6-二氟吡啶 在 sodium azide 、 四丁基溴化铵 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 以27%的产率得到2,6-diazidopyridine
  参考文献：
  名称：

  Anion binding and transport properties of cyclic 2,6-bis(1,2,3-triazol-1-yl)pyridines

  摘要：

  一系列具有硫脲功能的环状2,6-双-(1,2,3-三唑基)-吡啶受体的阴离子结合和膜传输特性已被报道。

  DOI：

  10.1039/c4ob02236j

文献信息

• Design and microwave-assisted synthesis of dimers of 1,5-benzodiazepine-1,2,3-triazole hybrids bearing alkyl/aryl spacers and their biological assessment
  作者：Zouhour Jaafar、Sami Chniti、Ahlem Ben Sassi、Hayet Dziri、Sylvain Marque、Marc Lecouvey、Rafik Gharbi、Moncef Msaddek

  DOI：10.1016/j.molstruc.2019.06.018

  日期：2019.11

  Large series of novel N-bis-1,2,3-triazolo-linked-1,5-benzodiazepin-2-ones (BZD) have been synthesized under microwave irradiation through a Cu(I)-catalyzed double 1,3-dipolar alkyne-azide coupling reaction. This process is of considerable synthetic advantages in terms of time saving and remarkable yields. The chemical structures of the isolated compounds have been elucidated on the basis of extensive spectroscopic methods including 1D & 2D NMR, IR and HRMS. All the synthesized compounds have been evaluated for their antimicrobial and antioxidant activities. In vitro antimicrobial environment, almost all of compounds have shown an interesting activity. Among the dimers of 1,5-benzodiazepine-1,2,3-triazole compounds tested, the results revealed that the potent antibacterial was recorded to compounds 3g,l for Gram-positive (within MIC = 31.25 and 125 mu g/mL), and 3h,k for Gram-negative (within MIC = 31.25 and 125 mu g/mL). Besides, the results demonstrate that compounds 3h,k have demonstrated the strongest potential against all the tested fungus (within MIC = 62.5 and 125 mu g/mL). The antioxidant evaluation indicated that most compounds exhibited a moderate to good biological activity. (C) 2019 Elsevier B.V. All rights reserved.