6-[4-(1-ethoxycarbonylethoxy)]phenoxy-5-(3-fluorophenyl)-3-methylthio-1-phenylpyrazolo[3,4-d]pyrimidin-4-one | 950829-43-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-[4-(1-ethoxycarbonylethoxy)]phenoxy-5-(3-fluorophenyl)-3-methylthio-1-phenylpyrazolo[3,4-d]pyrimidin-4-one
• 英文别名: Ethyl 2-[4-[5-(3-fluorophenyl)-3-methylsulfanyl-4-oxo-1-phenylpyrazolo[3,4-d]pyrimidin-6-yl]oxyphenoxy]propanoate
• CAS: 950829-43-3
• 化学式: C₂₉H₂₅FN₄O₅S
• 分子量: 560.606
• InChiKey: ARIDSBBLRRRQMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  40
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  121
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  6-[4-(1-ethoxycarbonylethoxy)]phenoxy-5-(3-fluorophenyl)-3-methylthio-1-phenylpyrazolo[3,4-d]pyrimidin-4-one 在 sodium tungstate 、 双氧水 作用下， 以 溶剂黄146 为溶剂， 反应 5.0h， 以82%的产率得到6-[4-(1-ethoxycarbonylethoxy)]phenoxy-5-(3-fluorophenyl)-3-methylsulfonyl-1-phenylpyrazolo[3,4-d]pyrimidin-4-one
  参考文献：
  名称：

  A novel synthesis and herbicidal activity of fluorine-containing pyrazolo[3,4-d]pyrimidin-4-one derivatives

  摘要：

  The 6-(4-alkoxycarbonylalkoxy)phenoxy-3-alkylthio-5-(fluoro-substituted)phenyl-l-phenylpyrazolo[3,4-d]pyrimidin-4-ones 6 have been successfully synthesized via a tandem aza-Wittig and annulation reactions of the corresponding iminophosphorances 4, aromatic isocyanate, and substituted phenols 2 in 59-69% isolated yields using actonitrile as solvent. These novel compounds 6 could be oxidized to sulfones 7 by hydrogen peroxide in satisfactory yields (57-93%). Their structures were clearly verified by spectroscopic data (IR, H-1 NMR, C-13 NMR, MS, Elemental analysis or X-ray diffraction crystallography). The results of preliminary bioassay indicated that these compounds possess herbicidal activity against the root of rape and barnyard grass. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2006.08.008
• 作为产物：
  描述：

  、 (R)-(+)-2-(4-羟基苯氧基)丙酸乙酯 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 5.0h， 以65%的产率得到6-[4-(1-ethoxycarbonylethoxy)]phenoxy-5-(3-fluorophenyl)-3-methylthio-1-phenylpyrazolo[3,4-d]pyrimidin-4-one
  参考文献：
  名称：

  A novel synthesis and herbicidal activity of fluorine-containing pyrazolo[3,4-d]pyrimidin-4-one derivatives

  摘要：

  The 6-(4-alkoxycarbonylalkoxy)phenoxy-3-alkylthio-5-(fluoro-substituted)phenyl-l-phenylpyrazolo[3,4-d]pyrimidin-4-ones 6 have been successfully synthesized via a tandem aza-Wittig and annulation reactions of the corresponding iminophosphorances 4, aromatic isocyanate, and substituted phenols 2 in 59-69% isolated yields using actonitrile as solvent. These novel compounds 6 could be oxidized to sulfones 7 by hydrogen peroxide in satisfactory yields (57-93%). Their structures were clearly verified by spectroscopic data (IR, H-1 NMR, C-13 NMR, MS, Elemental analysis or X-ray diffraction crystallography). The results of preliminary bioassay indicated that these compounds possess herbicidal activity against the root of rape and barnyard grass. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2006.08.008

文献信息

• A novel synthesis and herbicidal activity of fluorine-containing pyrazolo[3,4-d]pyrimidin-4-one derivatives
  作者：Hui Liu、Hong-Qing Wang、Ming-Wu Ding、Zhao-Jie Liu、Wen-Jing Xiao

  DOI：10.1016/j.jfluchem.2006.08.008

  日期：2006.12

  The 6-(4-alkoxycarbonylalkoxy)phenoxy-3-alkylthio-5-(fluoro-substituted)phenyl-l-phenylpyrazolo[3,4-d]pyrimidin-4-ones 6 have been successfully synthesized via a tandem aza-Wittig and annulation reactions of the corresponding iminophosphorances 4, aromatic isocyanate, and substituted phenols 2 in 59-69% isolated yields using actonitrile as solvent. These novel compounds 6 could be oxidized to sulfones 7 by hydrogen peroxide in satisfactory yields (57-93%). Their structures were clearly verified by spectroscopic data (IR, H-1 NMR, C-13 NMR, MS, Elemental analysis or X-ray diffraction crystallography). The results of preliminary bioassay indicated that these compounds possess herbicidal activity against the root of rape and barnyard grass. (c) 2006 Elsevier B.V. All rights reserved.