N-ethyl-N,2-diphenylacetamide | 125576-06-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-ethyl-N,2-diphenylacetamide
• 英文别名: phenyl-acetic acid-(N-ethyl-anilide)；Phenyl-essigsaeure-(N-aethyl-anilid)；phenylacetylphenylethylamine
• CAS: 125576-06-9
• 化学式: C₁₆H₁₇NO
• 分子量: 239.317
• InChiKey: DWMVLTLKRBOONM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  甲醇 、 N-ethyl-N,2-diphenylacetamide 在 叔丁基过氧化氢 、 cobalt(II) chloride hexahydrate 、 caesium carbonate 作用下， 以 甲醇 、 正己烷 、 水 为溶剂， 反应 24.0h， 以76%的产率得到N-ethyl-3-hydroxy-N,2-diphenylpropanamide
  参考文献：
  名称：

  Cobalt-catalyzed direct α-hydroxymethylation of amides with methanol as a C1 source

  摘要：

  一种以钴为催化剂，使用甲醇作为C1源进行酰胺的α-羟甲基化反应已经开发出来。

  DOI：

  10.1039/d1cc06501g
• 作为产物：
  描述：

  2-苯基乙酰苯胺 以4%的产率得到
  参考文献：
  名称：

  Antonovi Duan G., Mijin Duan ., Stojanovi Nadeda D., Jeremi Ljiljana A., +, J. Serb. Chem. Soc, 59 (1994) N 12, S 967-971

  摘要：

  DOI：

文献信息

• Direct Amidation of Carboxylic Acids with Tertiary Amines: Amide Formation over Copper Catalysts through C-N Bond Cleavage
  作者：Biquan Xiong、Longzhi Zhu、Xiaofeng Feng、Jian Lei、Tieqiao Chen、Yongbo Zhou、Li-Biao Han、Chak-Tong Au、Shuang-Feng Yin

  DOI：10.1002/ejoc.201402332

  日期：2014.7

  A copper-catalyzed system for the amidation of carboxylic acids with tert-amines through C–N bond cleavage was developed. This protocol is practical and represents a simple way to produce functionalized amides from basic starting materials in moderate to good yields. A plausible mechanism is proposed for the reaction.

  开发了一种铜催化系统，用于羧酸与叔胺通过 C-N 键裂解进行酰胺化。该协议是实用的，代表了一种从基本原料中以中等至良好的产率生产功能化酰胺的简单方法。提出了一个合理的反应机理。
• PHENYL-CONTAINING N-ACYL AMINE AND AMINOACID DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF, A PHARMACEUTICAL COMPOSITION AND THE USE THEREOF
  申请人：Obschestvo S Ogranichennoi Otvetstennostiyu "Pharmenterprises"

  公开号：EP1876169A1

  公开（公告）日：2008-01-09

  The present invention relates to novel phenyl-N-acyl derivatives of biogenic amines and amino acids of general formula (I) as cyclooxynease inhibitors, possessing analgetic and anti-inflammatory properties and devoid of side effects in particular ulcerogeneity and pro-spasmodic actions, as well as capability to potentiate effect of other analgetics, and possessing in addition antihypoxic, antidepressant and anti-Parkinsonistic action; as well as to the processes for the preparation novel and known phenyl-N-acyl derivatives of biogenic amines, to a pharmaceutical composition and to an agent comprising compounds of general formula (I) as well as to use thereof and a method of treating.

  本发明涉及作为环氧化酶抑制剂的通式（I）生物胺和氨基酸的新型苯基-N-酰基衍生物，该衍生物具有镇痛和抗炎特性，无副作用，特别是无溃疡性和促痉挛作用，并能增强其他镇痛药的效果，此外还具有抗缺氧、抗抑郁和抗帕金森病作用；以及生物胺的新型和已知苯基-N-酰基衍生物的制备工艺、药物组合物和包含通式（I）化合物的制剂及其用途和治疗方法。
• Green and efficient choline hydroxide-promoted C(sp3)-H selenation of arylacetamides at room temperature
  作者：Jun-Bo Wang、Yu Guan、Bo-Xuan Huo、Rui Bai、Li-Ping Mo、Zhan-Hui Zhang

  DOI：10.1016/j.mcat.2024.114452

  日期：2024.10

  A novel, efficient and environmentally friendly synthetic method has been developed for C(sp)-H selenation of arylacetamides with readily available diselenides as selenating reagents at room temperature. This protocol is applicable to a list of wide-ranging arylacetamides and diselenides, and provides various α-selenylated aryl amide derivatives with high yield using choline hydroxide (ChOH) as a green

  开发了一种新颖、高效且​​环境友好的合成方法，用于在室温下以容易获得的二硒化物作为硒化试剂对芳基乙酰胺进行 C(sp)-H 硒化。该方案适用于一系列广泛的芳基乙酰胺和二硒化物，并使用氢氧化胆碱（ChOH）作为绿色促进剂和溶剂，无需任何过渡金属催化剂或氧化剂，高产率地提供各种α-硒化芳基酰胺衍生物。
• Mijin; Stojanovic; Petrovic, Russian Journal of Organic Chemistry, 1998, vol. 34, # 10, p. 1513 - 1514
  作者：Mijin、Stojanovic、Petrovic

  DOI：——

  日期：——
• Martin, Annales de Chimie (Cachan, France), 1959, vol. <13>1, p. 541,561
  作者：Martin

  DOI：——

  日期：——