2-(N,N-二甲氨基)-5-甲氧基苯酚 | 102439-34-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 2-(N,N-二甲氨基)-5-甲氧基苯酚
• 英文名称: 2-(N,N-dimethylamino)-5-methoxyphenol
• 英文别名: 2-Dimethylamino-5-methoxy-phenol；2-(Dimethylamino)-5-methoxyphenol；2-(dimethylamino)-5-methoxyphenol
• CAS: 102439-34-9
• 化学式: C₉H₁₃NO₂
• 分子量: 167.208
• InChiKey: WALUWQHOXQHKDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (4-甲氧基苯基)-二甲胺 在 间氯过氧苯甲酸 、 三氟乙酸酐 作用下， 以 二氯甲烷 为溶剂， 反应 5.25h， 生成 2-(N,N-二甲氨基)-5-甲氧基苯酚
  参考文献：
  名称：

  Metal-Free Functionalization of N,N-Dialkylanilines via Temporary Oxidation to N,N-Dialkylaniline N-Oxides and Group Transfer

  摘要：

  A simple set of protocols for the controlled elaboration of anilines is reported allowing access to a diverse array of aminophenols, aminoarylsulfonates, alkylated anilines, and aminoanilines in 29-95% yield in a single laboratory operation from easily isolable, bench-stable N,N-dialkylaniline N-oxides. The introduction of new C-O, C-C, and C-N bonds on the aromatic ring is made possible by a temporary increase in oxidation level and excision of a weak N-O bond.

  DOI：

  10.1021/ol501813s

文献信息

• Postgenomic prospects of success in drug development and pharmacotherapy
  作者：A Rane

  DOI：10.1038/sj.tpj.6500013

  日期：2001.1.1
• Metal-Free Functionalization of <i>N</i>,<i>N</i>-Dialkylanilines via Temporary Oxidation to <i>N</i>,<i>N</i>-Dialkylaniline <i>N</i>-Oxides and Group Transfer
  作者：Robert S. Lewis、Michael F. Wisthoff、J. Grissmerson、William J. Chain

  DOI：10.1021/ol501813s

  日期：2014.7.18

  A simple set of protocols for the controlled elaboration of anilines is reported allowing access to a diverse array of aminophenols, aminoarylsulfonates, alkylated anilines, and aminoanilines in 29-95% yield in a single laboratory operation from easily isolable, bench-stable N,N-dialkylaniline N-oxides. The introduction of new C-O, C-C, and C-N bonds on the aromatic ring is made possible by a temporary increase in oxidation level and excision of a weak N-O bond.