5-ethoxy-2-ethyl-4-phenyl-2H-pyridazin-3(2H)-one | 927396-10-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-ethoxy-2-ethyl-4-phenyl-2H-pyridazin-3(2H)-one
• 英文别名: 5-Ethoxy-2-ethyl-4-phenyl-3(2H)-pyridazinone；5-ethoxy-2-ethyl-4-phenylpyridazin-3-one
• CAS: 927396-10-9
• 化学式: C₁₄H₁₆N₂O₂
• 分子量: 244.293
• InChiKey: GGIOBNVDVVEOSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  41.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-chloro-5-ethoxy-2-ethyl-3(2H)-pyridazinone 、 苯硼酸 在 tris(dibenzylideneacetone)dipalladium (0) 4,4'-(phenylphosphinediyl)bis(2,6-dimethylmorpholine) 、 caesium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.5h， 以95%的产率得到5-ethoxy-2-ethyl-4-phenyl-2H-pyridazin-3(2H)-one
  参考文献：
  名称：

  Suzuki–Miyaura coupling reaction of aryl chlorides using di(2,6-dimethylmorpholino)phenylphosphine as ligand

  摘要：

  Suzuki-Miyaura coupling was achieved on a variety of aryl chlorides by using di(2,6-dimethylmorpholino)phenylphosphine (Ll) as a bulky electron-rich monoaryl phosphine ligand. We report the couplings of various chlorobenzenes and heteroaryl chlorides. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.12.001

文献信息

• Suzuki–Miyaura coupling reaction of aryl chlorides using di(2,6-dimethylmorpholino)phenylphosphine as ligand
  作者：Su-Dong Cho、Ho-Kyun Kim、Heung-seop Yim、Mi-Ra Kim、Jin-Kook Lee、Jeum-Jong Kim、Yong-Jin Yoon

  DOI：10.1016/j.tet.2006.12.001

  日期：2007.2

  Suzuki-Miyaura coupling was achieved on a variety of aryl chlorides by using di(2,6-dimethylmorpholino)phenylphosphine (Ll) as a bulky electron-rich monoaryl phosphine ligand. We report the couplings of various chlorobenzenes and heteroaryl chlorides. (c) 2006 Elsevier Ltd. All rights reserved.