bis(3-(dimethylamino)propyl)terephthalamide | 69425-93-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis(3-(dimethylamino)propyl)terephthalamide
• 英文别名: N,N′-bis(3-(dimethylamino)propyl)terephthalamide；1-N,4-N-bis[3-(dimethylamino)propyl]benzene-1,4-dicarboxamide
• CAS: 69425-93-0
• 化学式: C₁₈H₃₀N₄O₂
• 分子量: 334.462
• InChiKey: TWQXVDLVPAWZGC-UHFFFAOYSA-N

物化性质

• 沸点：
  542.3±45.0 °C(Predicted)
• 密度：
  1.056±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  24
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  64.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  bis(3-(dimethylamino)propyl)terephthalamide 、 溴代十二烷 以 丙酮 为溶剂， 反应 36.0h， 以71.27%的产率得到
  参考文献：
  名称：

  具有刚性酰胺基间隔基的新型阳离子双子表面活性剂的制备，表征和性能

  摘要：

  通过一系列的两步反应，合成了一系列带有刚性酰胺基作为间隔基的新型阳离子双子表面活性剂，分别命名为C 12 -PPDA-C 12，C 14 -PPDA-C 14和C 16 -PPDA-C 16。以对苯二甲酸二甲酯，N，N-二甲基丙二胺和烷基溴为原料。制备的化合物的化学结构通过IR，1 H和13确认。13 C NMR和元素分析。通过表面张力，电导率和荧光研究了合成化合物的表面活性。疏水烷基链中碳原子数目的增加，降低了临界胶束浓度（CMC），CMC处的表面张力和最小表面积。研究了其他相关性能，包括起泡能力和乳液稳定性。结果表明，合成的双子表面活性剂具有良好的表面性能，乳化性能和稳定的泡沫性能。

  DOI：

  10.1007/s11743-015-1752-0
• 作为产物：
  描述：

  对苯二甲酸二甲酯 、 N,N-二甲基-1,3-二氨基丙烷 反应 16.0h， 以90.6%的产率得到bis(3-(dimethylamino)propyl)terephthalamide
  参考文献：
  名称：

  具有刚性酰胺基间隔基的新型阳离子双子表面活性剂的制备，表征和性能

  摘要：

  通过一系列的两步反应，合成了一系列带有刚性酰胺基作为间隔基的新型阳离子双子表面活性剂，分别命名为C 12 -PPDA-C 12，C 14 -PPDA-C 14和C 16 -PPDA-C 16。以对苯二甲酸二甲酯，N，N-二甲基丙二胺和烷基溴为原料。制备的化合物的化学结构通过IR，1 H和13确认。13 C NMR和元素分析。通过表面张力，电导率和荧光研究了合成化合物的表面活性。疏水烷基链中碳原子数目的增加，降低了临界胶束浓度（CMC），CMC处的表面张力和最小表面积。研究了其他相关性能，包括起泡能力和乳液稳定性。结果表明，合成的双子表面活性剂具有良好的表面性能，乳化性能和稳定的泡沫性能。

  DOI：

  10.1007/s11743-015-1752-0

文献信息

• Polymers with antimicrobial functionalities
  申请人：International Business Machines Corporation

  公开号：US10653142B2

  公开（公告）日：2020-05-19

  Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality.

  本文提供了有关具有抗菌功能的聚合物的技术。例如，本文所述的一个或多个实施方案可涉及一种聚合物，该聚合物可包括一个重复的离子烯单元。重复离子烯单元可包括沿可降解骨架分布的阳离子。可降解骨架可包括对苯二甲酰胺结构。此外，重复离子烯单元还可具有抗菌功能。
• Hydrophilic polymers with antimicrobial functionalities
  申请人：International Business Machines Corporation

  公开号：US10687530B2

  公开（公告）日：2020-06-23

  Techniques regarding ionene and/or polyionene compositions with antimicrobial functionality and enhanced hydrophilicity are provided. For example, one or more embodiments can regard a chemical compound that can comprise an ionene unit, which can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. The ionene unit can have antimicrobial functionality. Further, the chemical compound can comprise a hydrophilic functional group covalently bonded to the ionene unit. Also, the chemical compound can have carbohydrate mimetic functionality.

  本文提供了有关具有抗菌功能和增强亲水性的离子烯和/或聚阴离子烯组合物的技术。例如，一个或多个实施方案可涉及一种化合物，该化合物可包括一个烯单元，该烯单元可包括沿着可降解骨架分布的阳离子。可降解骨架可包括对苯二甲酰胺结构。离子烯单元可以具有抗菌功能。此外，化合物还可包括与离子烯单元共价键合的亲水官能团。此外，化合物还可以具有碳水化合物模拟功能。
• Monomer compositions with antimicrobial functionality
  申请人：International Business Machines Corporation

  公开号：US10743537B2

  公开（公告）日：2020-08-18

  Techniques regarding ionene compositions with antimicrobial functionality are provided. For example, one or more embodiments can comprise a monomer, which can comprise a single ionene unit. The single ionene unit can comprise a cation distributed along a molecular backbone. Also, a hydrophobic functional group can be covalently bonded to the molecular backbone, and the single ionene unit can have antimicrobial functionality.

  提供了有关具有抗菌功能的离子烯组合物的技术。例如，一个或多个实施例可以包括单体，单体可以包括单个烯单元。单个离子烯单元可包括沿分子骨架分布的阳离子。此外，疏水官能团可与分子骨架共价键合，单个离子烯单元可具有抗微生物功能。
• Upcycling Poly(ethylene terephthalate) Refuse to Advanced Therapeutics for the Treatment of Nosocomial and Mycobacterial Infections
  作者：Jeremy P. K. Tan、Jason Tan、Nathanial Park、Kaijin Xu、Edward D. Chan、Chuan Yang、Victoria A. Piunova、Zhongkang Ji、Alexandra Lim、Jundan Shao、An Bai、Xiyuan Bai、Daniele Mantione、Haritz Sardon、Yi Yan Yang、James L. Hedrick

  DOI：10.1021/acs.macromol.9b01333

  日期：2019.10.22

  The discovery of antibiotics was one of the crowning achievements of the 20th century, revolutionizing the treatment of infectious disease. However, widespread improper use of antibiotics has led to the development of antibiotic-resistant bacteria, resulting in a healthcare crisis and the urgent need to develop new effective antibiotics. Moreover, current antibiotic therapies are inefficient in treating biofilm-protected and intracellular organisms such as Mycobacterium tuberculosis (Mtb) and non-tuberculous mycobacteria. Herein, we present a strategy for the construction of macromolecular antimicrobial compounds using a catalyst-free, polyaddition polymerization process of monomers derived from poly(ethylene terephthalate) (PET) refuse. The initial depolymerization of PET refuse via aminolysis is highly amenable and scalable process to access a broad array of functional tertiary amine-containing terephthalamide polymer-grade monomers. This new monomer platform was subsequently used to construct antimicrobial cationic polyionenes via a polyaddition polymerization. The composition and structure of the antimicrobial polyionenes were varied to study their antimicrobial activity against a broad spectrum of pathogenic microbes including Mtb. Polymers with optimized compositions have potent antimicrobial activity with low minimum inhibitory concentrations of 3.9-15.8 mu g/mL against microbes including Mtb and high selectivity for microbes over mammalian cells. Similarly, activity against Mtb ranged from 2 to 16 mu g/mL, while values for Mycobacterium avium and Mycobacterium abscessus were higher. In addition, antimicrobial polyionenes were able to target and kill M. avium residing inside human macrophages. Overall, PET refuse was successfully used as a feedstock to generate new functional terephthalamide monomers for new macromolecular antimicrobial polyionenes. These polyionenes are promising candidate agents to treat difficult-to-treat bacterial and mycobacterial infections that are currently resistant to existing antibiotics.
• BINDERS FOR COATINGS, HAVING HIGH WATER VAPOR PERMEABILITY
  申请人：Terrenoire Alexandre

  公开号：US20120010338A1

  公开（公告）日：2012-01-12

  The present invention relates to binders based on polymer dispersions and terephthalic bisamides with high water vapor transmission, and also to their use in formulations, especially for wood coatings.