((E)-phenylhydrazono)-acetonitrile | 13307-00-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ((E)-phenylhydrazono)-acetonitrile
• 英文别名: ((E)-Phenylhydrazono)-acetonitril；E-2-Phenylhydrazonoacetonitril；(2E)-2-(phenylhydrazinylidene)acetonitrile
• CAS: 13307-00-1
• 化学式: C₈H₇N₃
• 分子量: 145.164
• InChiKey: CSJDDTACWPPJKY-JXMROGBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  48.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ((E)-phenylhydrazono)-acetonitrile 在 吡啶 、 硫化氢 、 三乙胺 作用下， 生成 phenylhydrazono-thioacetamide
  参考文献：
  名称：

  Fairfull et al., Journal of the Chemical Society, 1952, p. 742

  摘要：

  DOI：
• 作为产物：
  描述：

  2-苯基-1,2,3-三唑-4-羧酸 在 barium dihydroxide 作用下， 生成 ((E)-phenylhydrazono)-acetonitrile
  参考文献：
  名称：

  Brecknell,D.J. et al., Australian Journal of Chemistry, 1969, vol. 22, p. 1915 - 1922

  摘要：

  DOI：

文献信息

• Cancer therapy system
  申请人：THERAPEUTICAL SYSTEMS CORPORATION

  公开号：EP0412211A1

  公开（公告）日：1991-02-13

  A method for effecting oncolysis, regression, and control of malignant neoplasms in humans and other mammals without adverse effects on normal body cells is described. An ATP-availability depressor may be combined with a defined nutritional regimen, a fatty acid blocker, an amino acid blocker, a lactate export blocker, or any combination thereof.

  本文描述了一种在不对正常体细胞产生不利影响的情况下，对人类和其他哺乳动物的恶性肿瘤进行溶解、消退和控制的方法。ATP 利用率抑制剂可与确定的营养方案、脂肪酸阻断剂、氨基酸阻断剂、乳酸输出阻断剂或它们的任何组合结合使用。
• A method of providing a gas composition in a biological tissue or fluid in vivo
  申请人：UNGER, Evan C

  公开号：EP0804944A2

  公开（公告）日：1997-11-05

  The invention provides a method of providing a gas composition in a biological tissue or fluid in vivo, the method comprising: (a) administering to a patient a composition which comprises a gaseous precursor, wherein the gaseous precursor forms a gas as a result of a change in temperature or pressure and, (b) applying ultrasound to a patient. Preferably, the gaseous precursor comprises a perfluorocarbon and preferably the ultrasound is applied using an ultrasound imaging device.

  本发明提供了一种在体内生物组织或流体中提供气体成分的方法，该方法包括 (a) 向患者施用包含气态前体的组合物，其中气态前体因温度或压力的变化而形成气体，并且、 (b) 对患者施加超声波。气态前体最好由全氟碳化物组成，超声波最好使用超声波成像设备。
• Method for hyperthermic potentiation of tissue
  申请人：UNGER, Evan C

  公开号：EP1104678A2

  公开（公告）日：2001-06-06

  Gas, gaseous precursors and perfluorocarbons are presented as novel potentiators for ultrasonic hyper-thermia. The gas, gaseous precursors and perfluorocarbons which may be administered into the vasculature, interstitially or into any body cavity are designed to accumulate in cancerous and diseased tissues. When therapeutic ultrasonic energy is applied to the diseased region heating is increased because of the greater effectiveness of sound energy absorption caused by these agents.

  气体、气体前体和全氟化碳是超声波热疗的新型增效剂。气体、气体前体和全氟化碳可被注入血管、间隙或任何体腔，旨在积聚在癌症和病变组织中。当治疗性超声波能量作用于病变区域时，由于这些制剂能更有效地吸收声能，因此会增加加热效果。
• Ultrasound imaging and treatment
  申请人：——

  公开号：US20020150539A1

  公开（公告）日：2002-10-17

  Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems. Gas, gaseous precursors and perfluorocarbons are presented as novel potentiators for ultrasonic hyper-thermia. The gas, gaseous precursors and perfluorocarbons which may be administered into the vasculature, interstitially or into any body cavity are designed to accumulate in cancerous and diseased tissues. When therapeutic ultrasonic energy is applied to the diseased region heating is increased because of the greater effectiveness of sound energy absorption caused by these agents.

  本文描述了制备温度活化的气体前体填充脂质体的方法和装置。通过这些方法制备的充满气体前体的脂质体尤其适用于超声波成像应用和治疗药物输送系统。 介绍了气体、气体前体和全氟化碳作为超声波高热的新型增效剂。气体、气体前体和全氟化碳可被注入血管、间隙或任何体腔，旨在积聚在癌症和病变组织中。当治疗性超声波能量作用于病变区域时，由于这些制剂能更有效地吸收声能，因此会增加加热效果。
• Methods for screening for AcrAB efflux pump inhibitors
  申请人：Buxser Earl Stephen

  公开号：US20050255538A1

  公开（公告）日：2005-11-17

  The invention relates to the field of antimicrobial agents, and to methods for the identification and characterization of potential antimicrobial agents and compounds which enhance the effect of antimicrobial agents. More specifically this invention relates to methods for screening agents for which the mode of action involves the acrAB family of efflux pumps.

  本发明涉及抗菌剂领域，以及潜在抗菌剂和增强抗菌剂效果的化合物的鉴定和表征方法。更具体地说，本发明涉及筛选作用模式涉及外排泵 acrAB 家族的制剂的方法。