N-anilino-N'-(2-morpholin-4-ylethyl)benzenecarboximidamide | 313650-73-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-anilino-N'-(2-morpholin-4-ylethyl)benzenecarboximidamide
• CAS: 313650-73-6
• 化学式: C₁₉H₂₄N₄O
• 分子量: 324.426
• InChiKey: XTCPFKNAMYCJRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  48.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-anilino-N'-(2-morpholin-4-ylethyl)benzenecarboximidamide 在 silver carbonate 作用下， 以 乙腈 为溶剂， 生成 4-[(2,5-Diphenyl-1,2,4-triazol-3-yl)methyl]morpholine
  参考文献：
  名称：

  An Improved Synthesis of 1,2,4-Triazoles using Ag2CO3

  摘要：

  An improved synthesis of 1,3,5-trisubstituted 1,2,4-triazoles via Ag2CO3 mediated cyclization of triazenes has been developed. This approach is flexible and compatible with a wide range of functional groups. The reaction was complete within 3 h and the products were isolated in moderate to high yields. The influence of the beta-substituents of the amines on the triazole formation was also studied. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00726-2
• 作为产物：
  描述：

  苯甲醛苯腙 在 N-氯代丁二酰亚胺 、 2,3-二巯基丁二酸 、 TEA 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 12.0h， 生成 N-anilino-N'-(2-morpholin-4-ylethyl)benzenecarboximidamide
  参考文献：
  名称：

  An Improved Synthesis of 1,2,4-Triazoles using Ag2CO3

  摘要：

  An improved synthesis of 1,3,5-trisubstituted 1,2,4-triazoles via Ag2CO3 mediated cyclization of triazenes has been developed. This approach is flexible and compatible with a wide range of functional groups. The reaction was complete within 3 h and the products were isolated in moderate to high yields. The influence of the beta-substituents of the amines on the triazole formation was also studied. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00726-2

文献信息

• An Improved Synthesis of 1,2,4-Triazoles using Ag2CO3
  作者：K Paulvannan、Tao Chen、Ron Hale

  DOI：10.1016/s0040-4020(00)00726-2

  日期：2000.10

  An improved synthesis of 1,3,5-trisubstituted 1,2,4-triazoles via Ag2CO3 mediated cyclization of triazenes has been developed. This approach is flexible and compatible with a wide range of functional groups. The reaction was complete within 3 h and the products were isolated in moderate to high yields. The influence of the beta-substituents of the amines on the triazole formation was also studied. (C) 2000 Elsevier Science Ltd. All rights reserved.