N-anilino-N'-prop-2-enylbenzenecarboximidamide | 313650-71-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-anilino-N'-prop-2-enylbenzenecarboximidamide
• CAS: 313650-71-4
• 化学式: C₁₆H₁₇N₃
• 分子量: 251.331
• InChiKey: NRRBSKZORLTXBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  36.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-anilino-N'-prop-2-enylbenzenecarboximidamide 在 silver carbonate 作用下， 以 乙腈 为溶剂， 生成 1,3-diphenyl-5-vinyl-1,2,4-triazole
  参考文献：
  名称：

  An Improved Synthesis of 1,2,4-Triazoles using Ag2CO3

  摘要：

  An improved synthesis of 1,3,5-trisubstituted 1,2,4-triazoles via Ag2CO3 mediated cyclization of triazenes has been developed. This approach is flexible and compatible with a wide range of functional groups. The reaction was complete within 3 h and the products were isolated in moderate to high yields. The influence of the beta-substituents of the amines on the triazole formation was also studied. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00726-2
• 作为产物：
  描述：

  苯甲醛苯腙 在 N-氯代丁二酰亚胺 、 2,3-二巯基丁二酸 、 TEA 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 12.0h， 生成 N-anilino-N'-prop-2-enylbenzenecarboximidamide
  参考文献：
  名称：

  An Improved Synthesis of 1,2,4-Triazoles using Ag2CO3

  摘要：

  An improved synthesis of 1,3,5-trisubstituted 1,2,4-triazoles via Ag2CO3 mediated cyclization of triazenes has been developed. This approach is flexible and compatible with a wide range of functional groups. The reaction was complete within 3 h and the products were isolated in moderate to high yields. The influence of the beta-substituents of the amines on the triazole formation was also studied. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00726-2

文献信息

• An Improved Synthesis of 1,2,4-Triazoles using Ag2CO3
  作者：K Paulvannan、Tao Chen、Ron Hale

  DOI：10.1016/s0040-4020(00)00726-2

  日期：2000.10

  An improved synthesis of 1,3,5-trisubstituted 1,2,4-triazoles via Ag2CO3 mediated cyclization of triazenes has been developed. This approach is flexible and compatible with a wide range of functional groups. The reaction was complete within 3 h and the products were isolated in moderate to high yields. The influence of the beta-substituents of the amines on the triazole formation was also studied. (C) 2000 Elsevier Science Ltd. All rights reserved.
• Cyclization of 1,2,4-triazenes to 1,2,4-triazoles using oxidizing reagents—NaClO, Ca(ClO)2, Dess–Martin periodinane and Ley's TPAP/NMO
  作者：K Paulvannan、Ron Hale、Daniel Sedehi、Tao Chen

  DOI：10.1016/s0040-4020(01)00976-0

  日期：2001.11

  A simple and efficient approach to 1,3,5-trisubstituted 1,2,4-triazoles via cyclization of 1,2,4-triazenes employing commonly used oxidizing agents such as NaClO, Ca(ClO)(2), Dess-Martin periodinane and Ley's oxidizing agent (TPAP/NMO) is described. The reaction proceeds under mild conditions and is compatible with various functional groups. Extension of this approach to prepare triazoles on solid support has also been investigated. (C) 2001 Elsevier Science Ltd. All rights reserved.