propoxyacetic acid | 17640-31-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: propoxyacetic acid
• 英文别名: n-propyl propoxyacetate；propoxy-acetic acid propyl ester；Propoxy-essigsaeure-propylester；Propylaetherglykolsaeurepropylester；Propyloxy-essigsaeure-propylester；Propyl 2-propoxyacetate
• CAS: 17640-31-2
• 化学式: C₈H₁₆O₃
• 分子量: 160.213
• InChiKey: BMVTVMIDGMNRRR-UHFFFAOYSA-N

物化性质

• 沸点：
  210.1±13.0 °C(Predicted)
• 密度：
  0.940±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  propoxyacetic acid 在 氨 、 水 作用下， 生成 propoxy-acetic acid amide
  参考文献：
  名称：

  Kilpi, Zeitschrift fur Physikalische Chemie, Stoechiometrie und Verwandtschaftslehre, 1912, vol. 80, p. 178

  摘要：

  DOI：
• 作为产物：
  描述：

  氯乙酸正丙酯 、 sodium n-propoxide 生成 propoxyacetic acid
  参考文献：
  名称：

  Schreiner, Justus Liebigs Annalen der Chemie, 1879, vol. 197, p. 13

  摘要：

  DOI：

文献信息

• 一种丙氧基乙酸的合成新工艺
  申请人：青岛和兴精细化学有限公司

  公开号：CN108299186B

  公开（公告）日：2021-02-12

  本发明公开了一种丙氧基乙酸的合成新工艺。该工艺包括下列步骤：1）反应：将丙醇钠分散于正丙醇中，向其中滴加氯乙酸的正丙醇溶液；滴加完毕，保温反应，用浓盐酸酸化；（2）除盐：过滤生成的氯化钠，滤饼用正丙醇淋洗，合并滤液与淋洗液；（3）精馏：滤液与淋洗液合并后，减压精馏，回收正丙醇，得到产品。本发明的有益效果：反应接近定量，产品总收率高达98%；废水不含盐，接近纯水，其各项指标均符合废水排放标准，可直接排放，不会造成环境污染，不会增加三废治理费用；滤出的盐用正丙醇洗涤回收有用成分后烘干，可作为副产出售。
• Novel propionic acid derivatives
  申请人：——

  公开号：US20040072690A1

  公开（公告）日：2004-04-15

  A compound represented by the following formula (1) or a salt thereof: 1 wherein R 1 represents a C 1-12 alkyl group, phenyl group, 1-naphthyl group and the like, R 2 represents a C 2-12 alkyl group, (R 3 ) b represents 0 to 4 substituents such as a halogen atom, R 4 represents a lower alkyl group, R 5 represents hydrogen atom or a lower alkyl group, n represents an integer from 2 to 4, and X represents —NH— or —O—, which has superior hypoglycemic action, hypolipidemic action and total cholesterol reducing action, and is useful as an active ingredient of a medicament for prophylactic and/or therapeutic treatment of diseases including diabetes mellitus, hyperlipidemia and the like.

  以下化合物的分子式（1）或其盐：其中R1代表C1-12烷基基团、苯基、1-萘基等，R2代表C2-12烷基基团，（R3）b代表0至4个卤原子等取代基，R4代表较低的烷基基团，R5代表氢原子或较低的烷基基团，n代表2至4的整数，X代表—NH—或—O—，具有优越的降糖作用、降脂作用和总胆固醇降低作用，可用作预防和/或治疗糖尿病、高脂血症等疾病的药物的活性成分。
• [EN] PROCESS FOR PRODUCING OPTICALLY ACTIVE 3-(4-HYDROXYPHENYL)PROPIONIC ACIDS<br/>[FR] PROCEDE DE PRODUCTION D'ACIDES 3-(4-HYDROXYPHENYL)PROPIONIQUES OPTIQUEMENT ACTIFS
  申请人：TAKASAGO PERFUMERY CO LTD

  公开号：WO2005051882A1

  公开（公告）日：2005-06-09

  The present invention relates to a process for producing an optically active 3-(4-hydroxyphenyl)propionic acid useful as intermediates for medicines, through short steps in good yield and with high optical purity. More specifically, the present invention relates to a process for producing an optically active 3-(4-hydroxyphenyl)propionic acid of the formula (6): wherein R2 is an alkyl group; R5 to R8 are each independently a hydrogen atom or a substituent; and the symbol * is an chiral carbon atom, or a salt thereof, which comprises reacting a benzaldehyde of the formula (1): wherein R1 is a protective group; and R5 to R8 are each the same as defined above, with a glycolic acid derivative of the formula (2): wherein R3 is a hydrocarbon group; and R2 is the same as defined above, hydrolyzing the resulting product to give a cinnamic acid of the formula (4): wherein R1, R2 and R5 to R8 are each the same as defined above, or a salt thereof, and subjecting the resulting cinnamic acid (4) or a salt thereof to asymmetric hydrogenation to give an optically active phenylpropionic acid of the formula (5): wherein all the symbols are each the same as defined above, or a salt thereof, followed by deprotection.

  本发明涉及一种生产光学活性3-(4-羟基苯基)丙酸的工艺，作为药物中间体，通过简短的步骤、高产率和高光学纯度。更具体地，本发明涉及一种生产光学活性3-(4-羟基苯基)丙酸的工艺，其化学结构如下（6）：其中R2是烷基；R5至R8分别独立地是氢原子或取代基；符号*是一个手性碳原子，或其盐，包括将化学结构如下（1）的苯甲醛：其中R1是保护基；R5至R8分别与上述定义相同，与化学结构如下（2）的甘醇酸衍生物反应：其中R3是烃基；R2与上述定义相同，水解得到肉桂酸的产物：其中R1、R2和R5至R8分别与上述定义相同，或其盐，并将得到的肉桂酸（4）或其盐进行不对称氢化反应，得到光学活性苯丙酸的产物：其中所有符号均与上述定义相同，或其盐，随后进行去保护处理。
• Process for producing optically active 3-(4-hydroxyphenyl)proprionic acids
  申请人：Yokozawa Tohru

  公开号：US20070142472A1

  公开（公告）日：2007-06-21

  The present invention relates to a process for producing an optically active 3-(4-hydroxyphenyl)propionic acid useful as intermediates for medicines, through short steps in good yield and with high optical purity. More specifically, the present invention relates to a process for producing an optically active 3-(4-hydroxyphenyl)propionic acid of the formula (6): wherein R 2 is an alkyl group; R 5 to R 8 are each independently a hydrogen atom or a substituent; and the symbol * is an chiral carbon atom, or a salt thereof, which comprises reacting a benzaldehyde of the formula (1): wherein R 1 is a protective group; and R 5 to R 8 are each the same as defined above, with a glycolic acid derivative of the formula (2): wherein R 3 is a hydrocarbon group; and R 2 is the same as defined above, hydrolyzing the resulting product to give a cinnamic acid of the formula (4): wherein R 1 , R 2 and R 5 to R 8 are each the same as defined above, or a salt thereof, and subjecting the resulting cinnamic acid (4) or a salt thereof to asymmetric hydrogenation to give an optically active phenylpropionic acid of the formula (5): wherein all the symbols are each the same as defined above, or a salt thereof, followed by deprotection.

  本发明涉及一种生产光学活性的3-(4-羟基苯基)丙酸的方法，该方法通过短步骤以良好产率和高光学纯度的方式，作为药物中间体。更具体地说，本发明涉及一种生产式(6)的光学活性3-(4-羟基苯基)丙酸的方法：其中R2是烷基；R5到R8分别独立地是氢原子或取代基；符号*是手性碳原子，或其盐，包括用式(1)的苯甲醛反应：其中R1是保护基；R5到R8分别与上述定义相同，与式(2)的乙二醇酸衍生物反应：其中R3是碳氢基团；R2与上述定义相同，水解所得产物得到式(4)的肉桂酸：其中R1、R2和R5到R8分别与上述定义相同，或其盐，并将所得的肉桂酸(4)或其盐经过不对称氢化作用得到式(5)的光学活性苯丙酸：其中所有符号均与上述定义相同，或其盐，然后去保护基。
• METHOD FOR PRODUCING EPOXY COMPOUND HAVING CYANURIC ACID SKELETON
  申请人：Takeyama Toshiaki

  公开号：US20130172525A1

  公开（公告）日：2013-07-04

  There is provided an epoxy compound that provides properties of cured products combining high transparency with high flexural strength by being thermally cured while maintaining advantageous handling properties in a liquid state thereof; and a method for producing a composition by using the epoxy compound. A method for producing an epoxy compound of Formula (1): (in Formula (1), n1, n2, and n3 are individually any one of integers of 2 to 6; n4, n5, and n6 are individually an integer of 2; n7, n8, and n9 are individually an integer of 1; and R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are independently a hydrogen atom or a C 1-10 alkyl group), including: reacting cyanuric chloride with a C 4-8 alkenol and reacting the obtained compound having an unsaturated bond with a peroxide.

  本发明提供了一种环氧化合物，通过在液态下保持有利的处理性能，热固化后具有高透明度和高弯曲强度的固化产品特性；以及使用该环氧化合物制备组合物的方法。一种制备式（1）环氧化合物的方法：（在式（1）中，n1、n2和n3分别为2至6的任意整数；n4、n5和n6分别为2的整数；n7、n8和n9分别为1的整数；R1、R2、R3、R4、R5和R6独立地为氢原子或C1-10烷基）包括：将三聚氰氯与C4-8烯醇反应，并将所得具有不饱和键的化合物与过氧化物反应。