2-bromobenzylphosphonic acid | 80395-13-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-bromobenzylphosphonic acid
• 英文别名: (2-Brom-benzyl)-phosphonsaeure；(2-Bromophenyl)methylphosphonic acid
• CAS: 80395-13-7
• 化学式: C₇H₈BrO₃P
• 分子量: 251.016
• InChiKey: NJCDXQHIGFGNKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4,4'-联吡啶 、 2-bromobenzylphosphonic acid 、 水 、 cobalt(II) nitrate 以 乙醇 为溶剂， 反应 24.0h， 以36%的产率得到
  参考文献：
  名称：

  Halogen bonding interactions assisted network expansion of a tetrahedral cobalt phosphonate coordination polymer bearing 4,4′-bipyridine ligand

  摘要：

  DOI：

  10.1016/j.molstruc.2020.129063
• 作为产物：
  描述：

  2-溴溴苄 在 亚磷酸三乙酯 作用下， 反应 24.0h， 以95%的产率得到2-bromobenzylphosphonic acid
  参考文献：
  名称：

  Halogen bonding interactions assisted network expansion of a tetrahedral cobalt phosphonate coordination polymer bearing 4,4′-bipyridine ligand

  摘要：

  DOI：

  10.1016/j.molstruc.2020.129063

文献信息

• [EN] METHODS AND SYSTEMS FOR PREPARING IRREVERSIBLE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES<br/>[FR] PROCÉDÉS ET SYSTÈMES POUR PRÉPARER DES INHIBITEURS IRRÉVERSIBLES DE PROTÉINES TYROSINES PHOSPHATASES
  申请人：UNIV ALBERTA

  公开号：WO2011106898A1

  公开（公告）日：2011-09-09

  Described herein are the preparation and use of novel bromo- phosphonomethylphenylalanine amino acid derivatives (BrPmp) and BrPmp-containing peptides as specific, irreversible protein tyrosine phosphatase inhibitors, which are suitable for application in peptide synthesis. These derivatives are particularly advantageous since their synthesis is both easy and scalable, and they are suitable for peptide synthesis. The BrPmp derivatives described herein can be appropriately protected to allow for solid phase peptide synthesis (SPPS) and incorporation into peptides for preparation of protein tyrosine phosphatase inhibitors and inhibitor libraries. The peptides and peptide libraries can be used to identify new protein tyrosine phosphatase specific sequences and profile protein tyrosine phosphatase activity in cell lysates, diagnostic samples and biopsy samples.

  在本发明中，描述了新颖的溴代磷酰甲基苯丙氨酸氨基酸衍生物（BrPmp）及其含BrPmp肽段的制备和应用，这些衍生物是特异性的、不可逆的蛋白酪氨酸磷酸酶抑制剂，适用于肽合成中的应用。这些衍生物的合成既简单又可放大，适合于肽合成。所述的BrPmp衍生物可以适当地进行保护，以便进行固相肽合成（SPPS）并并入肽中，用于制备蛋白酪氨酸磷酸酶抑制剂和抑制剂库。所得到的肽和肽库可用于识别新的蛋白酪氨酸磷酸酶特异序列，并在细胞裂解液、诊断样本和活检样本中分析蛋白酪氨酸磷酸酶的活性。
• Activity-based probes for protein tyrosine phosphatases
  申请人：Zhang Zhong-Yin

  公开号：US20050233469A1

  公开（公告）日：2005-10-20

  Provided are compounds capable of covalently binding to a protein tyrosine phosphatase (PTP). The compounds comprise Formula A: Also provided are compositions comprising one of the above compounds covalently bound to a member of the PTP superfamily, methods of labeling a PTP using the compounds, methods of isolating a PTP from a mixture of proteins using the compounds, methods of evaluating whether a substance is an inhibitor of a PTP using the compounds, methods of evaluating the specificity of an inhibitor of a PTP using the compounds, methods of identifying a PTP involved in a disease in a mammal using the compounds, and methods of diagnosing a disease in a mammal using the compounds.

  提供的化合物能够共价结合到蛋白酪氨酸磷酸酶（PTP）。这些化合物包括公式A：此外还提供了包含以上一种化合物与PTP超家族成员共价结合的组合物，使用这些化合物标记PTP的方法，使用这些化合物从混合蛋白中分离PTP的方法，使用这些化合物评估物质是否为PTP抑制剂的方法，使用这些化合物评估PTP抑制剂的特异性的方法，使用这些化合物鉴定哺乳动物中与疾病相关的PTP的方法，以及使用这些化合物诊断哺乳动物中的疾病的方法。
• Pyridine compounds as inhibitors of dipeptidyl peptidase IV
  申请人：Oi Satoru

  公开号：US20070037807A1

  公开（公告）日：2007-02-15

  A compound represented by the formula wherein R 1 and R 2 are the same or different and each is an optionally substituted hydrocarbon group or an optionally substituted hydroxy group; R 3 is an optionally substituted aromatic group; R 4 is an optionally substituted amino group; L is a divalent chain hydrocarbon group; Q is a bond or a divalent chain hydrocarbon group; and X is a hydrogen atom, a cyano group, a nitro group, an acyl group, a substituted hydroxy group, an optionally substituted thiol group, an optionally substituted amino group or an optionally substituted cyclic group; provided that when X is an ethoxycarbonyl group, then Q is a divalent chain hydrocarbon group. The compound has a peptidase inhibitory action, is useful as an agent for the prophylaxis or treatment of diabetes and the like, and is superior in efficacy, duration of action, specificity, lower toxicity and the like.

  该化合物的化学式为其中R1和R2是相同或不同的可选择取代的烃基或可选择取代的羟基；R3是可选择取代的芳香基；R4是可选择取代的氨基；L是二价链烃基；Q是键或二价链烃基；X是氢原子、氰基、硝基、酰基、可选择取代的羟基、可选择取代的硫醇基、可选择取代的氨基或可选择取代的环状基；但当X是乙氧羰基时，Q是二价链烃基。该化合物具有肽酶抑制作用，可用作预防或治疗糖尿病等药物，具有优异的疗效、持续时间、特异性、低毒性等特点。
• POLYMER ELECTROLYTE COMPOSITION AND POLYMER ELECTROLYTE MEMBRANE, MEMBRANE-ELECTROLYTE ASSEMBLY, AND SOLID POLYMER FUEL CELL USING SAME
  申请人：Toray Industries, Inc.

  公开号：EP3131145A1

  公开（公告）日：2017-02-15

  [Problem] To provide: a polymer electrolyte composition that has excellent chemical stability that makes it possible to withstand a strong oxidizing atmosphere during fuel cell operation, that makes it possible to achieve excellent protonic conductivity under low humidity conditions, excellent mechanical strength, and excellent physical durability, and that is highly practical; and a polymer electrolyte membrane, a membrane-electrode assembly, and a solid polymer fuel cell that use the polymer electrolyte composition. [Solution] A polymer electrolyte composition that comprises at least an ionic group-containing polymer (A), an organic phosphorus-based additive (C), and a nitrogen-containing heteroaromatic ring system additive (D) and that is characterized by the nitrogen-containing heteroaromatic ring system additive (D) comprising at least three nitrogen-containing heteroaromatic rings within a molecule thereof. In addition, the polymer electrolyte membrane, the catalyst layer-equipped electrolyte membrane, the membrane-electrode assembly, and the solid polymer fuel cell of the present invention are characterized by being configured using the polymer electrolyte composition.

  问题 提供一种聚合物电解质组合物，该组合物具有优异的化学稳定性，能够在燃料电池运行期间耐受强氧化性气氛，能够在低湿度条件下实现优异的质子电导率，具有优异的机械强度和优异的物理耐久性，并且具有很高的实用性；以及一种使用该聚合物电解质组合物的聚合物电解质膜、膜电极组件和固体聚合物燃料电池。[解决方案]一种聚合物电解质组合物，它至少包含一种含离子基团的聚合物（A）、一种有机磷基添加剂（C）和一种含氮杂芳香族环系添加剂（D），其特征在于含氮杂芳香族环系添加剂（D）在其分子内至少包含三个含氮杂芳香族环。此外，本发明的聚合物电解质膜、配备催化剂层的电解质膜、膜电极组件和固体聚合物燃料电池的特征在于使用聚合物电解质组合物进行配置。
• Ultraviolet- and infrared-absorbing composition and ultraviolet- and infrared-absorbing filter
  申请人：Nippon Sheet Glass Company, Limited

  公开号：US11535726B2

  公开（公告）日：2022-12-27

  A UV-IR-absorbing composition according to the present invention includes: an absorber formed by a phosphonic acid represented by the following formula (a) and copper ion, the absorber being dispersed in the UV-IR-absorbing composition; a phosphoric acid ester allowing the absorber to be dispersed; a matrix resin; and an alkoxysilane monomer.

  根据本发明的紫外线-红外线吸收组合物包括：由下式（a）代表的膦酸和铜离子形成的吸收剂，吸收剂分散在紫外线-红外线吸收组合物中；允许吸收剂分散的磷酸酯；基质树脂；以及烷氧基硅烷单体。