3-methylbenzyl 3'-nitrolbenzoate | 1070881-33-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-methylbenzyl 3'-nitrolbenzoate
• 英文别名: 3-methylbenzyl 3-nitrobenzoate；3-Methylbenzyl 3'-nitrobenzoate；(3-methylphenyl)methyl 3-nitrobenzoate
• CAS: 1070881-33-2
• 化学式: C₁₅H₁₃NO₄
• 分子量: 271.273
• InChiKey: FMKDJBWHIHTMPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  间硝基苯甲醛 、 间二甲苯 在 叔丁基过氧化氢 作用下， 以 癸烷 、 乙腈 为溶剂， 反应 4.0h， 以88%的产率得到3-methylbenzyl 3'-nitrolbenzoate
  参考文献：
  名称：

  Titanium superoxide – a stable recyclable heterogeneous catalyst for oxidative esterification of aldehydes with alkylarenes or alcohols using TBHP as an oxidant

  摘要：

  一种利用可回收的非均相催化剂从醛类合成酯的单步催化方法被描述。

  DOI：

  10.1039/c5ob01586c

文献信息

• Inhibitory effects of benzyl benzoate and its derivatives on angiotensin II-induced hypertension
  作者：Osamu Ohno、Mao Ye、Tomoyuki Koyama、Kazunaga Yazawa、Emi Mura、Hiroshi Matsumoto、Takao Ichino、Kaoru Yamada、Kazuhiko Nakamura、Tomohiro Ohno、Kohji Yamaguchi、Junji Ishida、Akiyoshi Fukamizu、Daisuke Uemura

  DOI：10.1016/j.bmc.2008.03.056

  日期：2008.8

  Hypertension is a lifestyle-related disease which often leads to serious conditions such as heart disease and cerebral hemorrhage. Angiotensin II (Ang II) plays an important role in regulating cardiovascular homeostasis. Consequently, antagonists that block the interaction of Ang II with its receptors are thought to be effective in the suppression of hypertension. In this study, we searched for plant compounds that had antagonist-like activity toward Ang II receptors. From among 435 plant samples, we found that EtOH extract from the resin of sweet gum Liquidambar styraciflua strongly inhibited Ang II signaling. We isolated benzyl benzoate and benzyl cinnamate from this extract and found that those compounds inhibited the function of Ang II in a dose-dependent manner without cytotoxicity. An in vivo study showed that benzyl benzoate significantly suppressed Ang II-induced hypertension in mice. In addition, we synthesized more than 40 derivatives of benzyl benzoate and found that the meta-methyl and 3-methylbenzyl 2'-nitrobenzoate derivatives showed about 10-fold higher activity than benzyl benzoate itself. Thus, benzyl benzoate, its derivatives, and benzyl cinnamate may be useful for reducing hypertension. (c) 2008 Elsevier Ltd. All rights reserved.
• [EN] NOVEL SINGLE STEP ESTERIFICATION PROCESS OF ALDEHYDES USING A HETEROGENEOUS CATALYST<br/>[FR] NOUVEAU PROCÉDÉ D'ESTÉRIFICATION DES ALDÉHYDES EN UNE SEULE ÉTAPE À L'AIDE D'UN CATALYSEUR HÉTÉROGÈNE
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2016079759A1

  公开（公告）日：2016-05-26

  The present invention relates to a novel simple, efficient and single-step process for esterification of aldehydes using a heterogeneous catalyst with high yields. More particularly, the present invention relates to a novel simple, efficient and single-step process for esterification of aldehydes using Titanium superoxide with greater than 80% yields.
• Titanium superoxide – a stable recyclable heterogeneous catalyst for oxidative esterification of aldehydes with alkylarenes or alcohols using TBHP as an oxidant
  作者：Soumen Dey、Sunita K. Gadakh、A. Sudalai

  DOI：10.1039/c5ob01586c

  日期：——

  A single step catalytic approach for the synthesis of esters from aldehydes using a recyclable heterogeneous catalyst is described.

  一种利用可回收的非均相催化剂从醛类合成酯的单步催化方法被描述。