2'-bromo-[1,1'-biphenyl]-4-ol | 70066-66-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2'-bromo-[1,1'-biphenyl]-4-ol
• 英文别名: 2'-bromo-biphenyl-4-ol；2'-Brom-biphenyl-4-ol；4-(2-Bromophenyl)phenol
• CAS: 70066-66-9
• 化学式: C₁₂H₉BrO
• 分子量: 249.107
• InChiKey: XESUCEJPGYWGSK-UHFFFAOYSA-N

物化性质

• 沸点：
  342.1±17.0 °C(Predicted)
• 密度：
  1.471±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2'-bromo-[1,1'-biphenyl]-4-ol 、 环氧氯丙烷 在 alkaline solution 作用下， 生成 2-bromo-4'-(2,3-epoxy-propoxy)-biphenyl
  参考文献：
  名称：

  Ether

  摘要：

  公开号：

  US02181085A1
• 作为产物：
  描述：

  2-溴-4'-甲氧基联苯 在 三溴化硼 、 水 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以0.46 g的产率得到2'-bromo-[1,1'-biphenyl]-4-ol
  参考文献：
  名称：

  Palladium-Catalyzed Dynamic Kinetic Asymmetric Transformation of Racemic Biaryls: Axial-to-Central Chirality Transfer

  摘要：

  The first dynamic kinetic asymmetric transformation of racemic biaryl substrates on the basis of axial-to-central chirality transfer has been realized. Chiral Pd-NHC complexes were found to catalyze the dynamic kinetic asymmetric spiroannulation of 4-(2-bromoaryl)-naphthalen-1-ols (or 2'-bromo-[1,1'-biphenyl]-4-ols) with internal alkynes, affording a series of enantioenriched spirocyclic products bearing an all-carbon quaternary stereocenter in good yields (up to 95%) with excellent enantioselectivities (up to 97% ee).

  DOI：

  10.1021/jacs.5b01285

文献信息

• Palladium-catalyzed direct arylation of phenols with aryl iodides
  作者：Rongrong Long、Xufei Yan、Zhiqing Wu、Zhengkai Li、Haifeng Xiang、Xiangge Zhou

  DOI：10.1039/c5ob00132c

  日期：——

  An efficient protocol of palladium-catalyzed direct para-arylation of unfunctionalized phenols with aryl iodides under mild conditions was reported.

  一种高效的钯催化直接对未官能化酚进行芳基碘化的方法在温和条件下被报道。
• 4'-(Beta-alkyloxyethoxy)-4-cyanobiphenyl
  申请人：Chisso Corporation

  公开号：EP0047453A1

  公开（公告）日：1982-03-17

  A novel 4'-(β-alkyloxyethoxy)-4-cyanobiphenyl represented by the general formula: wherein R represents a straight alkyl group having from 1 to 6 carbon atoms, which is useful as one component of liquid crystal composition having positive dielectric anisotropy.

  一种通式如下的新型 4'-(β-烷氧基乙氧基)-4-氰基联苯： 其中 R 代表具有 1 至 6 个碳原子的直烷基，可用作具有正介电常数各向异性的液晶组合物的一种成分。
• 253. Phenylation with diazoaminobenzenes
  作者：R. L. Hardie、R. H. Thomson

  DOI：10.1039/jr9580001286

  日期：——
• Palladium-Catalyzed Dynamic Kinetic Asymmetric Transformation of Racemic Biaryls: Axial-to-Central Chirality Transfer
  作者：Liu Yang、Huayu Zheng、Lei Luo、Jiang Nan、Jingjing Liu、Yaoyu Wang、Xinjun Luan

  DOI：10.1021/jacs.5b01285

  日期：2015.4.22

  The first dynamic kinetic asymmetric transformation of racemic biaryl substrates on the basis of axial-to-central chirality transfer has been realized. Chiral Pd-NHC complexes were found to catalyze the dynamic kinetic asymmetric spiroannulation of 4-(2-bromoaryl)-naphthalen-1-ols (or 2'-bromo-[1,1'-biphenyl]-4-ols) with internal alkynes, affording a series of enantioenriched spirocyclic products bearing an all-carbon quaternary stereocenter in good yields (up to 95%) with excellent enantioselectivities (up to 97% ee).
• Ether
  申请人：DOW CHEMICAL CO

  公开号：US02181085A1

  公开（公告）日：1939-11-21