isobutyltriphenylphosphonium iodide | 60610-05-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: isobutyltriphenylphosphonium iodide
• 英文别名: (2-methylpropyl)triphenylphosphonium iodide；2-methylpropyl(triphenyl)phosphanium;iodide
• CAS: 60610-05-1
• 化学式: C₂₂H₂₄P*I
• 分子量: 446.311
• InChiKey: OVPOVBJOOFKCFI-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.64
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  isobutyltriphenylphosphonium iodide 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 生成 Isobutylidene-triphenyl-λ⁵-phosphane
  参考文献：
  名称：

  Cyclocondensation of oxalyl chloride with 1,2-glycols

  摘要：

  Oxalyl chloride reacts with a wide range of acyclic 1,2-glycols 1 in the presence of triethylamine to produce 1,3-dioxolan-2-ones 3 together with 1,4-dioxane-2,3-diones 2. Ethylene glycol (1d), monosubstituted ethylene glycols 1e, j-1, and erythro-1,2-disubstituted ethylene glycols 1f, m,o provide the cyclic carbonates 3 as the minor products, while the threo-compounds 1g, i, n,p,q and pinacol (1h) afford 3 as the main products. The formation of 3 may be rationalized in terms of stereoelectronically controlled cleavage of the conjugate base 17- of the tetrahedral intermediates. The rate for the conformational change of 17- into 18- and the equilibrium constant between these conformers are proposed to be the major factors affecting the reaction pattern.

  DOI：

  10.1016/s0040-4020(01)81546-5
• 作为产物：
  描述：

  氯苯 在 乙醚 、 sodium 、 三氯化磷 作用下， 生成 isobutyltriphenylphosphonium iodide
  参考文献：
  名称：

  Michaelis; v.Soden, Justus Liebigs Annalen der Chemie, 1885, vol. 229, p. 298

  摘要：

  DOI：

文献信息

• Enantioselective Hydroalkenylation of Olefins with Enol Sulfonates Enabled by Dual Copper Hydride and Palladium Catalysis
  作者：Alexander W. Schuppe、James Levi Knippel、Gustavo M. Borrajo-Calleja、Stephen L. Buchwald

  DOI：10.1021/jacs.1c02117

  日期：2021.4.14

  The catalytic enantioselective synthesis of α-chiral olefins represents a valuable strategy for rapid generation of structural diversity in divergent syntheses of complex targets. Herein, we report a protocol for the dual CuH- and Pd-catalyzed asymmetric Markovnikov hydroalkenylation of vinyl arenes and the anti-Markovnikov hydroalkenylation of unactivated olefins, in which readily available enol triflates

  α-手性烯烃的催化对映选择性合成代表了在复杂目标的不同合成中快速产生结构多样性的有价值的策略。在此，我们报告了一种用于双 CuH 和 Pd 催化的乙烯基芳烃的不对称马尔可夫尼科夫加氢烯基化和未活化烯烃的反马尔可夫尼科夫加氢烯基化的方案，其中容易获得的烯醇三氟甲磺酸酯可以用作烯基偶联伙伴。该方法可以合成多种α-手性烯烃，包括三取代和四取代的烯烃产品，而这些产品通过现有方法制备具有挑战性。
• Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity
  申请人：Carter H. Percy

  公开号：US20050054626A1

  公开（公告）日：2005-03-10

  The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis.

  本申请描述了MCP-1的调节剂，化学式为(I)：或其药用可接受的盐形式，用于预防哮喘、多发性硬化症、动脉粥样硬化和类风湿性关节炎。
• Correlation of proton chemical shift and 31P-H spin-spin coupling constants for organophosphorus derivatives
  作者：J.B. Hendrickson、M.L. Maddox、J.J. Sims、H.D. Kaesz

  DOI：10.1016/s0040-4020(01)93232-6

  日期：1964.1

  The chemical shifts and 31P-H spin-spin coupling constants of protons on saturated CH groups have been examined for a variety of model organophosphorus compounds. Correlations of these data with the charge on the phosphorus atom and proximity of hydrogen atoms to that nucleus are suggested and related to other data previously reported in the literature.

  对于各种模型有机磷化合物，已经研究了饱和CH基上质子的化学位移和31 P-H自旋-自旋偶合常数。提出了这些数据与磷原子上的电荷以及氢原子与该原子核的接近性的相关性，并与先前文献中报道的其他数据有关。
• [EN] HYODEOXYCHOLIC ACID DERIVATIVES AND USE THEREOF<br/>[FR] DÉRIVÉS D'ACIDE HYODEOXYCHOLIQUE ET LEURS UTILISATIONS
  申请人：BAR PHARMACEUTICALS SOCIETA' A RESPONSABILITA' LIMITATA

  公开号：WO2018002897A1

  公开（公告）日：2018-01-04

  The present invention concerns compounds having formula (I) and compositions thereof with a pharmacologically acceptable excipient and uses thereof as a medicament, in particular for the treatment and/or prevention of a disorder selected from the group consisting of: gastrointestinal disorders, liver diseases, cardiovascular and vascular diseases, pulmonary and metabolic diseases, infectious diseases, cancer, renal disorders, inflammatory disorders comprising immune mediated disorders, and neurological disorders.

  本发明涉及具有式（I）的化合物及其与药用可接受的赋形剂的组合物，以及其作为药物的用途，特别是用于治疗和/或预防来自以下组中选择的紊乱：胃肠道疾病、肝脏疾病、心血管和血管疾病、肺部和代谢性疾病、传染病、癌症、肾脏疾病、包括免疫介导紊乱的炎症性疾病以及神经疾病。
• Lincomycin derivatives possessing antibacterial activity
  申请人：VICURON PHARMACEUTICALS INC.

  公开号：US20040230046A1

  公开（公告）日：2004-11-18

  Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

  揭示了新颖的林可霉素衍生物。这些林可霉素衍生物表现出抗菌活性。由于本发明的化合物对细菌，包括革兰氏阳性生物，表现出强大的活性，它们是有用的抗微生物药剂。还公开了这些化合物的合成和使用方法。