(4-(1-phenylethyl)phenyl)methanol | 117455-21-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-(1-phenylethyl)phenyl)methanol
• 英文别名: 4-hydroxymethyl-α-methyldiphenylmethane；[4-(1-Phenylethyl)phenyl]methanol
• CAS: 117455-21-7
• 化学式: C₁₅H₁₆O
• 分子量: 212.291
• InChiKey: AUDJKVPCROOKIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-溴苄醇 、 乙基溴苯 在 新铜试剂 、 nickel(II) perchlorate hexahydrate 、 四丁基溴化铵 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 10.0h， 以71%的产率得到(4-(1-phenylethyl)phenyl)methanol
  参考文献：
  名称：

  镍催化的烷基卤与芳基卤的电化学还原中继交叉偶联。

  摘要：

  在未分开的电池中已经开发出芳基卤化物和烷基卤化物之间的高度区域选择性的镍催化的电化学还原中继交叉偶联。在这些温和的反应条件下可以耐受各种官能团，这为合成1,1-二芳基烷烃提供了另一种方法。

  DOI：

  10.1002/anie.201912753

文献信息

• TAILORED CONTROL OF SURFACE PROPERTIES BY CHEMICAL MODIFICATION
  申请人：Moloney Mark

  公开号：US20100068783A1

  公开（公告）日：2010-03-18

  A process for producing a substrate having an adhesive surface, which process comprises: (a) contacting the substrate with a carbene precursor, which carbene precursor is a compound of the following formula (1): whose substituent groups are SP defined herein, provided that when R is aryl or heteroaryl, said aryl or heteroaryl may be substituted by one, two, three, four or five groups, which groups are independently selected from various groups including -L B -W B ; and (b) either: (i) when W A or W B comprises an adhesive functional group, generating a carbene reactive intermediate from the carbene precursor so that it reacts with the substrate to functionalise the surface, thereby yielding said substrate having an adhesive surface; or (ii) when W A or W B comprises a group which is a precursor of an adhesive functional group, generating a carbene reactive intermediate from the carbene precursor so that it reacts with the substrate to functionalise the surface, and (c) converting said group which is a precursor into an adhesive functional group thereby yielding said substrate having an adhesive surface. The invention further relates to carbene precursor compounds for use in the process, substrates produced by the process and to processes for preparing certain precursor compounds.

  一种生产具有粘附表面的基板的方法，该方法包括：(a)将基板与卡宾前体接触，所述卡宾前体是以下式（1）的化合物：其取代基团为本文所定义的SP，但当R为芳基或杂环芳基时，所述芳基或杂环芳基可以被一个、两个、三个、四个或五个独立选择的各种取代基团之一取代，这些取代基团包括-LB-WB；和(b)：要么：(i)当WA或WB包含粘附功能基团时，从卡宾前体生成卡宾活性中间体，使其与基板反应以功能化表面，从而产生具有粘附表面的基板；或(ii)当WA或WB包含是粘附功能基团的前体时，从卡宾前体生成卡宾活性中间体，使其与基板反应以功能化表面，并且(c)将所述作为前体的基团转化为粘附功能基团，从而产生具有粘附表面的基板。该发明还涉及用于该方法的卡宾前体化合物，以及通过该方法生产的基板和用于制备某些前体化合物的方法。
• Salicylic acid copolymers and their metal salts, production process thereof, color-developing agents comprising metal salts of the copolymers and color-developing sheets employing the agents
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0268878A2

  公开（公告）日：1988-06-01

  Disclosed herein are salicylic acid copolymers having a weight average molecular weight of 500 10,000 and obtained (a) by condensing salicylic acid (i) with a benzyl alcohol (ii) and/or benzyl ether (iii) or a benzyl halide (iv) in the presence of an acid catalyst or (b) by reacting a co-condensation resin of (i) and (ii) and/or (iii) with (iv) or (c) by reacting a co-condensation resin of (i) and (ii) and/or (iii) or (iv) with a styrene derivative in the presence of an acid catalyst; multivalent metal salts of the salicylic acid copolymers; color-developing agents comprising the multivalent metal salts; and color-developing sheets suited for pressure-sensitive copying paper and comprising the color-developing agents. Their production processes are also disclosed.

  本文公开了水杨酸共聚物，其重量平均分子量为 500 10、000 的水杨酸共聚物；(a)在酸催化剂存在下，将水杨酸(i)与苄醇(ii)和/或苄醚(iii)或苄基卤化物(iv)缩合而得，或(b)将(i)和(ii)和/或(iii)的共缩合树脂与(iv)反应而得，或(c)在酸催化剂存在下，将(i)和(ii)和/或(iii)或(iv)的共缩合树脂与苯乙烯衍生物反应而得；水杨酸共聚物的多价金属盐；由多价金属盐组成的显色剂；以及由显色剂组成的适用于压敏复印纸的显色薄片。此外，还公开了它们的生产工艺。
• Color-developing compositions and their use
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0523697A1

  公开（公告）日：1993-01-20

  A color-developing composition comprises a multivalent-metal-modified salicylic acid resin (Resin A) and a polycondensation resin (resin B) at a weight ratio of 90-30 to 10-70. Resin A is composed of 5-35 mole% of a structural unit (I) and 65-95 mole% of at least one structural unit (II) or 65-95 mole% of a coupled structural unit of at least one unit (II) and at least one unit (III) and has a weight-average molecular weight of 350-5,000. Resin B is composed of the unit (II) and/or the unit (III) and has a weight-average molecular weight of 350-5,000. wherein Z represents M/m, M being a metal ion of m valence and m being an integer; R₁ and R₂ represent H or a C₁₋₁₂ alkyl, aralkyl, aryl or cycloalkyl group; R₃ and R₆ represent H or a C₁₋₄ alkyl group; and R₄ and R₅ represent H or CH₃.

  一种显色组合物包括一种多价金属改性水杨酸树脂（树脂 A）和一种缩聚树脂（树脂 B），两者的重量比为 90-30 比 10-70。树脂 A 由 5-35 摩尔%的结构单元（I）和 65-95 摩尔%的至少一个结构单元（II）或 65-95 摩尔%的至少一个单元（II）和至少一个单元（III）的耦合结构单元组成，其重量平均分子量为 350-5000。树脂 B 由单元（II）和/或单元（III）组成，重量平均分子量为 350-5000。 其中 Z 代表 M/m，M 为 m 价金属离子，m 为整数；R₁ 和 R₂ 代表 H 或 C₁₋₁₂ 烷基、芳基、芳烷基或环烷基；R₃ 和 R₆ 代表 H 或 C₁₋₄ 烷基；以及 R₄ 和 R₅ 代表 H 或 CH₃。
• Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0594149A2

  公开（公告）日：1994-04-27

  This invention provides a condensed pyrazole derivative of the Formula (1) : (where A denotes CH or N, RO and R3 denote same or different, a hydrogen atom or a lower alkyl group, R1 and R2 denote same or different, a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a nitro group or a halogen atom, m denotes 1 or 2, and n denotes 1, 2 or 3, provided that, when n is 2, two R2 may be connected to each other to form a lower alkylenedioxy group), or its pharmaceutically acceptable salt. This derivative or its salt is excellent in the effect of inhibiting the expression of action of androgen, thereby being excellent in therapeutical effect of benign prostatic hypertrophy, prostatic carcinoma, etc., and has a long lasting of efficacy and high oral absorption.

  本发明提供了一种式（1）的缩合吡唑衍生物： (其中A表示CH或N，RO和R3表示相同或不同的氢原子或低级烷基，R1和R2表示相同或不同的氢原子、低级烷基、低级烷氧基、低级烷硫基、硝基或卤素原子，m表示1或2，n表示1、2或3，但当n为2时，两个R2可相互连接形成低级烷二氧基)，或其药学上可接受的盐。该衍生物或其盐具有良好的抑制雄激素作用表达的效果，从而对良性前列腺肥大、前列腺癌等具有良好的治疗效果，且药效持久，口服吸收率高。
• Han, Chong; Buchwald, Stephen L., Journal of the American Chemical Society, 2009, vol. 131, p. 7532 - 7533
  作者：Han, Chong、Buchwald, Stephen L.

  DOI：——

  日期：——