2-(3,5-dichlorophenyl)-5-methyl-1H-benzimidazole | 1415330-53-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-(3,5-dichlorophenyl)-5-methyl-1H-benzimidazole
• 英文别名: 2-(3,5-Dichlorophenyl)-5-methyl-1 h-benzimidazole；2-(3,5-dichlorophenyl)-6-methyl-1H-benzimidazole
• CAS: 1415330-53-8
• 化学式: C₁₄H₁₀Cl₂N₂
• 分子量: 277.153
• InChiKey: NLUWJLQZIQYVSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3,5-二氯苯甲醛 、 3,4-二氨基甲苯 在 磷酸铁(III) 、 氧气 作用下， 以 neat (no solvent) 为溶剂， 反应 0.12h， 以85%的产率得到2-(3,5-dichlorophenyl)-5-methyl-1H-benzimidazole
  参考文献：
  名称：

  One-pot synthesis of 2-substituted benzimidazoles catalyzed by anhydrous FePO4

  摘要：

  Anhydrous FePO4 has been employed as a catalyst for efficient synthesis of 2-substituted benzimidazoles. Simple and convenient procedure, easy purification and shorter reaction time are the advantages of this method, resulting in several known and three new compounds.

  DOI：

  10.1007/s10593-012-1093-0

文献信息

• One-pot synthesis of 2-substituted benzimidazoles catalyzed by anhydrous FePO4
  作者：Farahnaz K. Behbahani、Parisa Ziaei

  DOI：10.1007/s10593-012-1093-0

  日期：2012.10

  Anhydrous FePO4 has been employed as a catalyst for efficient synthesis of 2-substituted benzimidazoles. Simple and convenient procedure, easy purification and shorter reaction time are the advantages of this method, resulting in several known and three new compounds.