磷酸铁(III) | 765207-04-3

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 过渡金属氧阴离子化合物
• 中文名称: 磷酸铁(III)
• 英文名称: iron(III) phosphate
• 英文别名: iron phosphate；ferric phosphate；[Phosphato(3-)-|EO]iron；iron(3+);phosphate
• CAS: 765207-04-3
• 化学式: Fe*O₄P
• 分子量: 150.818
• InChiKey: WBJZTOZJJYAKHQ-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  -2.83
• 重原子数：
  6
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  86.2
• 氢给体数：
  0
• 氢受体数：
  4

ADMET

毒理性

• 副作用

职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒案例。

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，如有必要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测休克并视需要进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用生理盐水连续冲洗每只眼睛……。不要使用催吐剂。对于误食，如果患者能够吞咽，有强烈的呕吐反射，且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释。/铁及其相关化合物/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. /Iron and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

高级治疗：对于无意识的病人，考虑进行口咽或鼻咽气管插管以控制气道。监测心率和必要时治疗心律失常。开始静脉输液，使用乳酸钠林格氏液/生理盐水： "保持开放"，最低流速。注意液体过载的迹象。对于伴有低血容量症状的低血压，谨慎给予液体。注意液体过载的迹象。使用丙美卡因氢氯化物协助眼部冲洗。/铁及其相关化合物/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with lactated Ringer's /SRP: "To keep open", minimal flow rate/. Watch for signs of fluid overload. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Iron and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

保持呼吸道通畅，必要时协助通气。积极使用静脉晶体液治疗由出血性胃肠炎引起的休克，并在需要时输血。患者常常因为胃肠道丢失和液体转移到肠壁和间质空间而明显低血容量。如果出现昏迷、癫痫和代谢性酸中毒，则进行治疗。对于严重中毒的患者（例如，休克、严重酸中毒和/或血清铁> 500-600 mcg/dL），给予去铁胺。监测尿液，以发现特征性的橙色或粉红色去铁胺-铁复合物。当尿液恢复正常或血清铁水平降至正常范围时，可以停止治疗。长期使用去铁胺与成人呼吸窘迫综合征和耶尔森菌血症有关。

Maintain an open airway and assist ventilation if necessary. Treat shock caused by hemorrhagic gastrointestinitis aggressively with intravenous crystalloid fluids, and replace blood if needed. Patients are often markedly hypovolemic owing to gastrointestinal losses and third spacing of fluids into the intestinal wall and interstitial space. Treat coma, seizures, and metabolic acidosis if they occur. For seriously intoxicated victims (eg, shock, severe acidosis, and/or serum iron > 500-600 mcg/dL) administer deferoxamine. Monitor the urine for the urine for the characteristic orange or pink deferoxamine-iron complex. Therapy may be stopped when the urine returns to normal or when the serum iron level decreases to the normal range. Prolonged deferoxamine has been associated with adult respiratory distress syndrome and Yersinia sepsis.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

活性炭无效。不建议使用吐根糖浆，因为它可能加剧铁剂引起的胃肠道刺激，并干扰整个肠道冲洗。如果产品是液体配方或片剂被嚼碎，考虑洗胃。不要使用含磷酸盐的溶液进行灌洗；这可能导致生命威胁性的高钠血症、高磷血症和低钙血症。碳酸氢盐和去铁胺灌洗的效果值得怀疑。去铁胺灌洗无效，可能增强铁的吸收。整个肠道冲洗对于吞入的片剂非常有效，可以被视为一线治疗方法，特别是如果普通腹部X光片上可见大量片剂。大量摄入可能导致凝结物或团块。重复或长时间的整个肠道冲洗可能移除片剂。内窥镜检查或外科胃切开术很少需要。

Activated charcoal is not effective. Ipecac is not recommended, because it can aggravate iron-induced gastrointestinal irritation and interfere with whole bowel irrigation. Consider gastric lavage if product was a liquid formulation or tablets were chewed. Do-not use phosphate-containing solutions for lavage; these may result in life-threatening hypernatremia, hyperphosphatemia, and hypocalcemia. Bicarbonate and deferoxamine lavage are of doubtful efficacy. Deferoxamine lavage is not effective and may enhance iron absorption. Whole-bowel irrigation is very effective for ingested tablets and may be considered first-line treatment, especially if large numbers of tablets are visible on plain abdominal x-ray. Massive ingestions may lead to concretions or bezoars. Repeated or prolonged whole-bowel irrigation may remove tablets. Endoscopy or surgical gastrotomy is rarely required.

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  磷酸铁(III) 在 Na₂SO₄ or K₂SO₄ 作用下， 以 neat (no solvent) 为溶剂， 生成 iron(II,III) oxide
  参考文献：
  名称：

  Debray, H., Liebigs Annalen der Chemie, 1861, vol. 120, p. 184

  摘要：

  DOI：
• 作为产物：
  描述：

  [Fe(H2O)(carboxymethylphosphonate)] 以 neat (no solvent) 为溶剂， 生成 磷酸铁(III)
  参考文献：
  名称：

  层状Fe（III）羧甲基膦酸酯的水热合成，结构和磁性能：[Fe（H 2 O）（O 3 P–CH 2 –CO 2）]或MIL-49

  摘要：

  [Fe III（H 2 O）（O 3 P–（CH 2）–CO 2）]或MIL-49在自生压力下于170°C水热合成48 h。它的二维结构由单斜空间群P 2 1 / c（No.14）中的单晶X射线衍射解决。细胞参数是一个= 9.3836（3）埃，b = 6.3798（3）埃，c ^ = 10.1371（3）A，β = 111.891（2）°，Ž = 4，V = 563.10（4）3。结构细化的可靠性因子为R 1（F）= 0.0470和对于I > 2σ（I）的1036次反射，wR 2（F 2）= 0.1297 。MIL-49的结构基于由两个边缘共享[FeO 5（H 2 O）]八面体和两个羧甲基膦酸酯基组成的无机单元。这些单元的连接导致混合片的形成。来自羧基官能团的悬垂的氧原子指向层间空间，并负责与相邻层的氢键结合。磁性测量和57 FeMössbauer的研究表明，低于T N = 25（1）K时

  DOI：

  10.1006/jssc.2001.9505
• 作为试剂：
  描述：

  乙酸酐 、 4-甲氧基苄醇 在 磷酸铁(III) 作用下， 反应 10.0h， 以93%的产率得到4-甲氧基苄基乙酸酯
  参考文献：
  名称：

  Iron (III) Phosphate as a Green and Reusable Catalyst Promoted Chemo Selective Acetylation of Alcohols and Phenols with Acetic Anhydride Under Solvent Free Conditions at Room Temperature

  摘要：

  在无溶剂条件下，使用磷酸铁(III)作为高效催化剂，在室温下对醇和酚进行化学选择性乙酰化反应，并获得了高产率的乙酰化化合物。磷酸铁(III)由于其固有的固体性质、可重复使用性和高催化活性，也是一种潜在的绿色催化剂。

  DOI：

  10.5012/jkcs.2011.55.4.633

文献信息

• FePO4/SiO2 Catalysts for Propylene Glycol Oxidation
  作者：D. Yu. Ebert、A. S. Savel’eva、N. V. Dorofeeva、O. V. Vodyankina

  DOI：10.1134/s0023158417060040

  日期：2017.11

  FePО4/SiO2 supported catalysts with a different content of iron phosphate are prepared. The properties of the catalyst are changed by the introduction of alkali metal compounds (Na or Cs) on its surface. The samples obtained are characterized by X-ray diffraction, low-temperature nitrogen adsorption, temperatureprogrammed reduction by hydrogen, and temperature-programmed desorption of ammonia. The

  FePО 4 /二氧化硅2制备与磷酸铁的含量不同的负载型催化剂。催化剂的性能通过在其表面上引入碱金属化合物（Na或Cs）而改变。获得的样品通过X射线衍射，低温氮吸附，氢气程序升温还原和程序升温氨解吸进行表征。在气相丙二醇氧化反应中研究了催化性能。结果表明，未改性催化剂上甲基乙二醛生成的选择性取决于负载的活性组分的状态及其在反应混合物的作用下的还原-氧化能力。
• Olefins from Natural Gas by Oxychlorination
  作者：Guido Zichittella、Nicolas Aellen、Vladimir Paunović、Amol P. Amrute、Javier Pérez-Ramírez

  DOI：10.1002/anie.201706624

  日期：2017.10.23

  growing gap between demand and manufacture. Reported herein is an exceptional europium oxychloride (EuOCl) catalyst for the selective (≥95 %) production of light olefins from ethane and propane by oxychlorination chemistry, thus achieving yields of ethylene (90 %) and propylene (40 %) unparalleled by any existing olefin production technology. Moreover, EuOCl is able to process mixtures of methane, ethane

  乙烯和丙烯是化学工业的重要组成部分，但当前的工艺无法弥补需求与制造之间日益扩大的差距。本文报道的是一种特殊的三氯氧化euro（EuOCl）催化剂，可通过氧氯化化学从乙烷和丙烷选择性地生产（≥95％）轻质烯烃，从而实现乙烯（90％）和丙烯（40％）的收率，这是任何现有方法所无法比拟的烯烃生产技术。此外，EuOCl能够处理甲烷，乙烷和丙烷的混合物以生产烯烃，从而降低天然气中烷烃的分离成本。最后，将EuOCl催化剂负载在合适的载体上并以挤出物形式进行评估，并在实际工艺条件下将其性能保持> 150小时。
• M(IO₃)(HPO₄)(H₂O) (M = Sc, Fe, Ga, In): Introduction of Phosphate Anions into Metal Iodates
  作者：Tong-Ying Chang、Bing-Ping Yang、Chun-Li Hu、Dong Yan、Jiang-Gao Mao

  DOI：10.1021/acs.cgd.7b00924

  日期：2017.9.6

  The first series of metal phosphate iodates, namely, M(IO3)(HPO4)(H2O) (M = Sc 1, Fe 2, Ga 3, In 4), have been obtained through hydrothermal syntheses. The title compounds are isomorphic and crystallize in the monoclinic space group C2/c (No. 15). Their structures feature a three-dimensional (3D) network composed of 1D [M(HPO4)(H2O)]+ chains that are further bridged by IO3 groups, forming 1D tunnels

  通过水热合成获得了第一系列的金属磷酸盐碘酸盐，即M（IO 3）（HPO 4）（H 2 O）（M = Sc 1，Fe 2，Ga 3，In 4）。标题化合物是同构的，并且在单斜空间群C 2 / c（No. 15）中结晶。它们的结构具有由1D [M（HPO 4）（H 2 O）] +链组成的三维（3D）网络，这些链进一步由IO 3组桥接，形成基于沿b的八元环的一维隧道。-轴。磁性测量显示化合物2中磁性中心之间的反铁磁耦合相互作用。紫外吸收光谱测量表明，化合物2在约427nm处显示出宽的吸收峰。的TGA研究和IR谱对化合物1 - 4还进行。
• Synthesis of iron orthophosphate catalysts by solution and solution combustion methods for the hydroxylation of benzene to phenol
  作者：Demet Baykan、Nursen Altuntas Oztas

  DOI：10.1016/j.materresbull.2015.01.019

  日期：2015.4

  prepared by solution and solution combustion method for use as a catalyst in the hydroxylation of benzene to phenol. The products of each method were structurally identical. The morphology and size of the catalyst were significantly influenced by the synthesis method. The catalytic activity of the catalysts in the liquid phase hydroxylation of benzene was studied. The yields of the solution combustion

  摘要 采用溶液法和溶液燃烧法制备了正磷酸铁，用作苯羟基化制苯酚的催化剂。每种方法的产物在结构上是相同的。催化剂的形貌和尺寸受合成方法的显着影响。研究了催化剂在苯液相羟基化反应中的催化活性。在优化条件下，溶液燃烧合成和溶液合成正磷酸铁的产率分别为24.52%和8.90%。溶液燃烧法合成的正磷酸铁比溶液法制备的正磷酸铁具有更好的催化性能。
• Process for selective reduction of propionic acid from (meth)acrylic acid product streams
  申请人：Han Scott

  公开号：US20090076303A1

  公开（公告）日：2009-03-19

  The present invention relates to an improved process for the selective reduction of propionic acid, hereinafter “PA”, impurity from an acrylic acid, hereinafter “AA” stream.

  本发明涉及一种改进的工艺，用于从丙酸丙烯酸流中选择性减少丙酸（以下简称“PA”）杂质。

表征谱图