2-(二甲基氨基)-4-嘧啶羧酸 | 933759-45-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 2-(二甲基氨基)-4-嘧啶羧酸
• 中文别名: 2-(二甲胺基)嘧啶-4-甲酸
• 英文名称: 2-(Dimethylamino)pyrimidine-4-carboxylic acid
• CAS: 933759-45-6
• 化学式: C₇H₉N₃O₂
• 分子量: 167.17
• InChiKey: WVCYPLUPYMEHMY-UHFFFAOYSA-N

物化性质

• 沸点：
  360.9±34.0 °C(Predicted)
• 密度：
  1.322±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  66.3
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2933599090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

文献信息

• Aryl substituted pyridines, pyrimidines, pyrazines and triazines and the use thereof
  申请人：Hogenkamp J. Derk

  公开号：US20050043305A1

  公开（公告）日：2005-02-24

  This invention relates aryl substituted pyridines, pyrimidines, pyrazines and triazines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein A 1 , A 2 , A 3 , R 1 —R 4 , X and Y are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

  本发明涉及式I的芳基取代的吡啶、嘧啶、吡嗪和三嗪化合物，或其药学上可接受的盐、前药或溶剂化物，其中A1、A2、A3、R1—R4、X和Y在说明书中设置。本发明还涉及将式I化合物用于治疗全局和局部缺血后的神经损伤，用于治疗或预防神经退行性疾病，如肌萎缩性侧索硬化症（ALS），以及用于治疗、预防或改善急性或慢性疼痛，作为抗耳鸣剂，抗癫痫药物和抗躁狂抑郁药物，局部麻醉剂，抗心律失常药物，以及用于治疗或预防糖尿病神经病变。
• Novel cyclic compound having pyrimidinylalkylthio group
  申请人：Tajima Hisashi

  公开号：US20110124646A1

  公开（公告）日：2011-05-26

  A method of treating a disease associated with angiogenesis by administering a therapeutically effective amount of a compound represented by the formula (1) or a salt thereof wherein the ring X represents R 1 and R 2 independently represent a hydrogen atom, an alkyl, an aryl or an aromatic heterocyclic; R 3 represents a hydrogen atom, a halogen atom, a hydroxy, an alkoxy, an aryloxy, an alkyl, an aryl, an amino, an alkylamino, a cycloalkylamino, an arylamino, an alkylcarbonylamino, an arylcarbonylamino, a mercapto, an alkylthio, an arylthio, an alkylsulfinyl or a nonaromatic heterocyclic; A 1 represents a sulfur atom, a sulfinyl or a sulfonyl; and A 2 represents an alkylene.

  通过给予化合物公式（1）或其盐的治疗有效量，治疗与血管生成相关的疾病的方法，其中环X代表R1和R2分别代表氢原子，烷基，芳基或芳香族杂环；R3代表氢原子，卤原子，羟基，烷氧基，芳氧基，烷基，芳基，氨基，烷基氨基，环烷基氨基，芳基氨基，烷基羰基氨基，芳基羰基氨基，巯基，烷硫基，芳硫基，烷基亚磺酰基或非芳香族杂环；A1代表硫原子，亚磺酰基或磺酰基；A2代表烷基。
• DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES
  申请人：Janssen Sciences Ireland Unlimited Company

  公开号：EP3814326A1

  公开（公告）日：2021-05-05
• US6867210B2
  申请人：——

  公开号：US6867210B2

  公开（公告）日：2005-03-15
• US8507485B2
  申请人：——

  公开号：US8507485B2

  公开（公告）日：2013-08-13