furan-2-carbodithioic acid | 37501-28-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: furan-2-carbodithioic acid
• 英文别名: Furan-2-dithiocarbonsaeure
• CAS: 37501-28-3
• 化学式: C₅H₄OS₂
• 分子量: 144.218
• InChiKey: BXUHIVHBPUOIBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  furan-2-carbodithioic acid 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 2-(2-bromophenyl)-3-(furan-2-yl)-3-(methylthio)acrylonitrile
  参考文献：
  名称：

  Synthesis of N-Functionalized/NH-Multisubstituted Indoles, Thienopyrroles, Pyrroloindoles, and Pyrazolopyrroles via Sequential One-Pot Base-Mediated and Copper-Catalyzed Inter- and Intramolecular Amination of 2-[2-Bromo(het)aryl]-3-(het)aryl-3-(methylthio)acrylonitriles

  摘要：

  A novel, efficient route to substituted 1-N-(het)aryl/NH-2-(het)aryl-3-cyanoindoles and related pyrrolo-fused heterocycles such as thienopyrroles, pyrroloindoles, and pyrazolopyrroles has been reported. The overall protocol involves sequential cycloamination of readily available 2-[2-bromo(het)aryl]-3-(het)aryl-3-(methylthio)acrylonitrile precursors with primary amines or amides via two key C-N bond-forming processes, one base-mediated intermolecular and the other Cu-catalyzed intramolecular arylamination leading to N(1)-C(2) and N(1)-C(7a) bond formation, respectively, in a two-step one-pot procedure.

  DOI：

  10.1021/jo501114a
• 作为产物：
  描述：

  糠醛 在 yellow ammonium sulfide 、 水 作用下， 生成 furan-2-carbodithioic acid
  参考文献：
  名称：

  Bruni; Levi, Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1923, vol. <5> 32 I, p. 7

  摘要：

  DOI：

文献信息

• OXIDATIVE CONDENSATION REACTIONS OF AMINES WITH CARBIDITHIOATES AND XANTHATES¹
  作者：GLEN ALLIGER、G. E. P. SMITH、E. L. CARR、H. P. STEVENS

  DOI：10.1021/jo01158a005

  日期：1949.11
• Manufacture of dithio derivatives from aldehydes
  申请人：QUAKER OATS CO

  公开号：US01756158A1

  公开（公告）日：1930-04-29
• DE403123
  申请人：——

  公开号：——

  公开（公告）日：——
• Synthesis of N-Functionalized/NH-Multisubstituted Indoles, Thienopyrroles, Pyrroloindoles, and Pyrazolopyrroles via Sequential One-Pot Base-Mediated and Copper-Catalyzed Inter- and Intramolecular Amination of 2-[2-Bromo(het)aryl]-3-(het)aryl-3-(methylthio)acrylonitriles
  作者：S. Vijay Kumar、B. Saraiah、G. Parameshwarappa、H. Ila、Girijesh K. Verma

  DOI：10.1021/jo501114a

  日期：2014.9.5

  A novel, efficient route to substituted 1-N-(het)aryl/NH-2-(het)aryl-3-cyanoindoles and related pyrrolo-fused heterocycles such as thienopyrroles, pyrroloindoles, and pyrazolopyrroles has been reported. The overall protocol involves sequential cycloamination of readily available 2-[2-bromo(het)aryl]-3-(het)aryl-3-(methylthio)acrylonitrile precursors with primary amines or amides via two key C-N bond-forming processes, one base-mediated intermolecular and the other Cu-catalyzed intramolecular arylamination leading to N(1)-C(2) and N(1)-C(7a) bond formation, respectively, in a two-step one-pot procedure.
• Bruni; Levi, Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1923, vol. <5> 32 I, p. 7
  作者：Bruni、Levi

  DOI：——

  日期：——