5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-chloro-8-(2,4-dichloro-phenyl)-2-methyl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidine | 474103-39-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-chloro-8-(2,4-dichloro-phenyl)-2-methyl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidine
• 英文别名: tert-butyl-[[4-chloro-8-(2,4-dichlorophenyl)-2-methyl-6,7-dihydro-5H-pyrido[2,3-d]pyrimidin-5-yl]methoxy]-diphenylsilane
• CAS: 474103-39-4
• 化学式: C₃₁H₃₂Cl₃N₃OSi
• 分子量: 597.059
• InChiKey: ZXKGPENEMLGUOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.95
• 重原子数：
  39
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-chloro-8-(2,4-dichloro-phenyl)-2-methyl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidine 在 4-二甲氨基吡啶 、 lithium hydroxide 、 triethylamine tris(hydrogen fluoride) 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 8.33h， 生成 [(S)-4-Chloro-8-(2,4-dichloro-phenyl)-2-methyl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-5-yl]-methanol
  参考文献：
  名称：

  Substituted tetraazaacenaphthylenes as potent CRF1 receptor antagonists for the treatment of depression and anxiety

  摘要：

  Two isomers of the hexahydro-tetraazaacenaphthylene templates (1 and 2) are presented as novel, potent, and selective corticotropin releasing factor-1 (CRF1) receptor antagonists. In this paper, we report the affinity and SAR of a series of compounds, as well as pharmacokinetic characterization of a chosen set. The anxiolitic activity of a selected example (2ba) in the rat pup vocalization model is also presented. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.05.040
• 作为产物：
  描述：

  1,1,2-乙烷三羧酸三乙酯 在 咪唑 、 甲醇 、 4-二甲氨基吡啶 、 sodium 、 sodium hydride 、 二异丁基氢化铝 、 臭氧 、 三乙胺 、 三氟乙酸 、 lithium hexamethyldisilazane 、 三氯氧磷 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 165.83h， 生成 5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-chloro-8-(2,4-dichloro-phenyl)-2-methyl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidine
  参考文献：
  名称：

  Substituted tetraazaacenaphthylenes as potent CRF1 receptor antagonists for the treatment of depression and anxiety

  摘要：

  Two isomers of the hexahydro-tetraazaacenaphthylene templates (1 and 2) are presented as novel, potent, and selective corticotropin releasing factor-1 (CRF1) receptor antagonists. In this paper, we report the affinity and SAR of a series of compounds, as well as pharmacokinetic characterization of a chosen set. The anxiolitic activity of a selected example (2ba) in the rat pup vocalization model is also presented. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.05.040

文献信息

• Substituted tetraazaacenaphthylenes as potent CRF1 receptor antagonists for the treatment of depression and anxiety
  作者：Y. St-Denis、R. Di Fabio、G. Bernasconi、E. Castiglioni、S. Contini、D. Donati、E. Fazzolari、G. Gentile、D. Ghirlanda、C. Marchionni、F. Messina、F. Micheli、F. Pavone、A. Pasquarello、F.M. Sabbatini、M.G. Zampori、R. Arban、G. Vitulli

  DOI：10.1016/j.bmcl.2005.05.040

  日期：2005.8

  Two isomers of the hexahydro-tetraazaacenaphthylene templates (1 and 2) are presented as novel, potent, and selective corticotropin releasing factor-1 (CRF1) receptor antagonists. In this paper, we report the affinity and SAR of a series of compounds, as well as pharmacokinetic characterization of a chosen set. The anxiolitic activity of a selected example (2ba) in the rat pup vocalization model is also presented. (c) 2005 Elsevier Ltd. All rights reserved.