1-[2-(Furan-2-yl)-2-oxoethyl]-L-proline | 384339-75-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-[2-(Furan-2-yl)-2-oxoethyl]-L-proline
• 英文别名: (2S)-1-[2-(furan-2-yl)-2-oxoethyl]pyrrolidine-2-carboxylic acid
• CAS: 384339-75-7
• 化学式: C₁₁H₁₃NO₄
• 分子量: 223.22
• InChiKey: ANZSCHXDFDGXEJ-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  70.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Nutritional compositions and methods for treating or preventing osteoporosis
  申请人：Johnson D. Catherine

  公开号：US20060040001A1

  公开（公告）日：2006-02-23

  Disclosed are nutritional compositions and methods of using the compositions for treating or preventing osteoporosis. The compositions comprise (A) those dried fruit solids that inherently comprise flavonoids, hydroxycinnamic acids, and a fiber component of which at least about 20% by weight is soluble fiber, and (B) a soluble, indigestible oligosaccharide in addition to any soluble fiber inherently in the dried fruit solids. The dried fruit solids may also be characterized as those selected from dried plum, dried grape, dried date, or dried fig. The combination of dried fruit solids (e.g., dried plum solids) and soluble indigestible oligosaccharides (e.g., fructooligosaccharides) have been found to be surprisingly more effective in affecting bone mineral density than either component when used alone, thus allowing for reduced concentrations of such ingredients in a nutritional product form such as a beverage or solid nutritional bar.

  公开了用于治疗或预防骨质疏松症的营养组合物和使用组合物的方法。这些组合物包括：(A) 本身含有类黄酮、羟基肉桂酸和纤维成分的干果固体，其中至少约 20% （按重量计）是可溶性纤维；(B) 除了干果固体中固有的可溶性纤维外，还包括可溶性、难消化的低聚糖。果脯固形物也可以选自李子干、葡萄干、枣干或无花果干。研究发现，干果固体（如李子干固体）和可溶性难消化低聚糖（如果寡糖）的组合在影响骨矿物质密度方面的效果比单独使用其中任何一种成分都要好，因此可以降低营养产品（如饮料或固体营养棒）中此类成分的浓度。
• NUTRITIONAL COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING OSTEOPOROSIS
  申请人：ABBOTT LABORATORIES

  公开号：EP1773364A1

  公开（公告）日：2007-04-18
• Method for controlling body weight in estrogen-insufficient women
  申请人：Johnson D. Catherine

  公开号：US20070098821A1

  公开（公告）日：2007-05-03

  Disclosed are methods of controlling body weight in estrogen-insufficient women by administering compositions comprising (A) those dried fruit solids that inherently comprise flavonoids, hydroxycinnamic acids, and a fiber component of which at least about 20% by weight is soluble fiber, and (B) a soluble, indigestible oligosaccharide in addition to any soluble fiber inherently in the dried fruit solids. The dried fruit solids may also be characterized as those selected from dried plum, dried grape, dried date, or dried fig. Administration of dried fruit solids (e.g., dried plum solids) in combination with soluble indigestible oligosaccharides (e.g., fructooligosaccharides) are surprisingly effective in controlling body weight gain in estrogen-insufficient women.
• METHOD FOR CONTROLLING BODY WEIGHT IN ESTROGEN-INSUFFICIENT WOMEN
  申请人：Johnson Catherine D.

  公开号：US20080242592A1

  公开（公告）日：2008-10-02

  Disclosed are methods of controlling body weight in estrogen-insufficient women by administering compositions comprising (A) those dried fruit solids that inherently comprise flavonoids, hydroxycinnamic acids, and a fiber component of which at least about 20% by weight is soluble fiber, and (B) a soluble, indigestible oligosaccharide in addition to any soluble fiber inherently in the dried fruit solids. The dried fruit solids may also be characterized as those selected from dried plum, dried grape, dried date, or dried fig. Administration of dried fruit solids (e.g., dried plum solids) in combination with soluble indigestible oligosaccharides (e.g., fructooligosaccharides) are surprisingly effective in controlling body weight gain in estrogen-insufficient women.
• US7435431B2
  申请人：——

  公开号：US7435431B2

  公开（公告）日：2008-10-14