3,4-dihydro-2H-pyran-6-ylmethyl-methylimino-oxo-phenyl-lambda6-sulfane | 1200799-89-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4-dihydro-2H-pyran-6-ylmethyl-methylimino-oxo-phenyl-lambda6-sulfane
• 英文别名: 3,4-dihydro-2H-pyran-6-ylmethyl-methylimino-oxo-phenyl-λ6-sulfane
• CAS: 1200799-89-8
• 化学式: C₁₃H₁₇NO₂S
• 分子量: 251.349
• InChiKey: RLPMKEHZQDJZLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  47
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-溴戊酸乙酯 、 S-甲基-S-苯基-N-甲基亚砜亚胺 在 正丁基锂 、 sodium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 2.5h， 以35%的产率得到3,4-dihydro-2H-pyran-6-ylmethyl-methylimino-oxo-phenyl-lambda6-sulfane
  参考文献：
  名称：

  Consecutive reactions with sulfoximines: a direct access to 2-sulfonimidoylylidene tetrahydrofurans and 6-sulfonimidoylmethyl-3,4-dihydro-2H-pyrans

  摘要：

  2-Sulfonimidoylylidene tetrahydrofurans and 2-sulfonimidoylylidene-5-vinyl tetrahydrofurans were readily synthesized via a consecutive acylation/SN2 sequence with total regio- and chemoselectivity from Johnson's sulfoximine derivatives. The same consecutive reaction could also be applied to the expeditious synthesis of 6-sulfonimidoylmethyl-3,4-dihydro-2H-pyrans. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.09.080

文献信息

• Consecutive reactions with sulfoximines: a direct access to 2-sulfonimidoylylidene tetrahydrofurans and 6-sulfonimidoylmethyl-3,4-dihydro-2H-pyrans
  作者：Marie-Alice Virolleaud、Vellaisamy Sridharan、Damien Mailhol、Damien Bonne、Cyril Bressy、Gaëlle Chouraqui、Laurent Commeiras、Yoann Coquerel、Jean Rodriguez

  DOI：10.1016/j.tet.2009.09.080

  日期：2009.11

  2-Sulfonimidoylylidene tetrahydrofurans and 2-sulfonimidoylylidene-5-vinyl tetrahydrofurans were readily synthesized via a consecutive acylation/SN2 sequence with total regio- and chemoselectivity from Johnson's sulfoximine derivatives. The same consecutive reaction could also be applied to the expeditious synthesis of 6-sulfonimidoylmethyl-3,4-dihydro-2H-pyrans. (C) 2009 Elsevier Ltd. All rights reserved.