2-amino-3-cyano-7-methyl-1,8-naphthyridine | 1118437-92-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-amino-3-cyano-7-methyl-1,8-naphthyridine
• 英文别名: 2-Amino-7-methyl-1,8-naphthyridine-3-carbonitrile
• CAS: 1118437-92-5
• 化学式: C₁₀H₈N₄
• 分子量: 184.2
• InChiKey: GSQPCAYADXHTRW-UHFFFAOYSA-N

物化性质

• 沸点：
  400.3±45.0 °C(predicted)
• 密度：
  1.32±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  75.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  triselenium dicyanide 、 2-氨基-7-甲基-1,8-萘啶 以 二甲基亚砜 为溶剂， 反应 0.25h， 以43%的产率得到2-amino-3-cyano-7-methyl-1,8-naphthyridine
  参考文献：
  名称：

  Triselenium Dicyanide (TSD) as a New Cyanation Reagent: Synthesis of Cyano Pterins and Quinoxalines Along with Library of CyanoN-Heterocyclic Compounds

  摘要：

  Triselenium dicynide (TSD) has been reported for the first time to be a novel cyanation reagent for the microwave-assisted one-pot synthesis of a series of various types of cyano N-heterocycles such as pterin, deazapterin, quinoxaline, naphthyridine, and pyridine in good yields.

  DOI：

  10.1080/00397910802374141

文献信息

• Triselenium Dicyanide (TSD) as a New Cyanation Reagent: Synthesis of Cyano Pterins and Quinoxalines Along with Library of Cyano<i>N</i>-Heterocyclic Compounds
  作者：Shyamaprosad Goswami、Annada C. Maity、Nirmal K. Das、Debabrata Sen、Sibaprasad Maity

  DOI：10.1080/00397910802374141

  日期：2009.1.13

  Triselenium dicynide (TSD) has been reported for the first time to be a novel cyanation reagent for the microwave-assisted one-pot synthesis of a series of various types of cyano N-heterocycles such as pterin, deazapterin, quinoxaline, naphthyridine, and pyridine in good yields.