4-hydroxy-6-methyl-2H-pyran-2-one | 70254-61-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 4-hydroxy-6-methyl-2H-pyran-2-one
• 英文别名: 2-hydroxy-6-methyl-4-pyrone；hydroxy-2 methyl-6 pyrone；2-hydroxy-6-methyl-4H-pyran-4-one；6-Methyl-2.4-pyranon；2-hydroxy-6-methylpyran-4-one
• CAS: 70254-61-4
• 化学式: C₆H₆O₃
• 分子量: 126.112
• InChiKey: OOKCZXGEYPSNIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.65
• 重原子数：
  9.0
• 可旋转键数：
  0.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  50.44
• 氢给体数：
  1.0
• 氢受体数：
  3.0

安全信息

• 海关编码：
  2932999099
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319

反应信息

• 作为反应物：
  描述：

  4-hydroxy-6-methyl-2H-pyran-2-one 以 xylene 为溶剂， 反应 52.0h， 生成 4-(o-aminophenylacetimidoylmethylidene)-8-nitro-1,5-benzodiazepin-2-one
  参考文献：
  名称：

  Abbassi, M. El; Essassi, E. M.; Fifani, J., Bulletin des Societes Chimiques Belges, 1997, vol. 106, # 4, p. 205 - 210

  摘要：

  DOI：

文献信息

• Farnesyltransferase inhibitors
  申请人：——

  公开号：US20030087940A1

  公开（公告）日：2003-05-08

  Substituted imidazoles and thiazoles having the formula 1 are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

  具有以下化学式的取代咪唑和噻唑对抑制法尼基转移酶具有用处。还公开了抑制法尼基转移酶的组合物和在患者中抑制法尼基转移酶的方法。
• The synthesis of ethyl 2-[(2,2-dibenzoyl)ethenyl]amino-3-dimethyl-aminopropenoate and its application to the synthesis of fused 3-aminopyran-2-ones and 3-aminoazolo- and -azinopyrimidin-4(4<i>H</i>)-ones
  作者：Gorazd Soršak、Branko Stanovnik、Simona GoliČ Grdadolnik

  DOI：10.1002/jhet.5570350606

  日期：1998.11

  Ethyl 2-[(2,2-dibenzoyl)ethenyl]amino-3-dimethylaminopropenoate (3) was prepared from dibenzoylmethane (1) in two steps, and used as a reagent for preparation of fused substituted 3-aminopyranones 12–15 in over 90% yield, quinolizin-4-one 16 in over 79% yield, and fused pyrimidin-4-ones 17–19 in 40–50% yield. Deprotection of (2,2-dibenzoyl)ethenyl group with either diethylamine or hydrazine hydrate

  乙基2 - [（2,2-二苯甲酰基）乙烯基]氨基-3- dimethylaminopropenoate（3）由二苯甲酰基甲烷（制备1）在两个步骤中，并且用作用于制备稠合的取代的3- aminopyranones的试剂12-15在经产率为90％，喹啉嗪4酮16的产率超过79％，熔融嘧啶4酮17-19的产率为40-50％。用二乙胺或水合肼对（2，2-二苯甲酰基）乙烯基进行脱保护，分别得到游离氨基化合物20、21和22，产率分别为35％，91％和71％。
• [EN] KETAL ESTERS OF ANHYDROPENTITOLS AND USES THEREOF<br/>[FR] CÉTO-ESTERS D'ANHYDROPENTITOLS ET LEURS UTILISATIONS
  申请人：XLTERRA INC

  公开号：WO2010138842A1

  公开（公告）日：2010-12-02

  The present disclosure relates to the preparation of ketal compounds from anhydropentitols and oxocarboxylates; derivatives, homopolymers, and copolymers thereof; and various compositions, formulations, and articles derived therefrom.

  本公开涉及从无水戊糖醇和羰基羧酸酯制备缩酮化合物；以及它们的衍生物、同聚物和共聚物；以及由此衍生的各种组合物、配方和制品。
• Nouvelle synthese des benzodiazepines-1,5 a partir de la γ-pyrone
  作者：M. El Abbassi、E.M. Essassi、J. Fifani

  DOI：10.1016/s0040-4039(00)95934-3

  日期：——

  Reaction of 0-phenylenediamines 2, 3 with 2-hydroxy-6-methyl-4-pyrone leads to:2-butoxycarbonylmethylene-4-methyl-1,5-benzodiazepines 4, 5, 4-acetylmethylene-1,5-benzodiazepin-2-ones 6, 7, and benzimidazoles 8, 11. These compounds results from competitive reactions and different ways of cyclization.

  0-苯二胺2、3与2-羟基-6-甲基-4-吡喃酮反应生成：2-丁氧基羰基亚甲基-4-甲基-1,5-苯并二氮杂卓4，5，5，4-乙酰基亚甲基-1,5-苯并二氮杂卓- 2-ones 6、7和benzimidazoles 8、11。这些化合物来自竞争反应和不同的环化方式。
• [EN] KETAL AMIDE COMPOUNDS, METHODS OF MAKING, AND APPLICATIONS<br/>[FR] COMPOSÉS CÉTAL AMIDES, PROCÉDÉS DE FABRICATION ET APPLICATIONS
  申请人：SEGETIS INC

  公开号：WO2010075330A1

  公开（公告）日：2010-07-01

  Disclosed herein are ketal amide compounds. The ketal amide compounds are synthesized by the reaction of ketal acids or ketal esters with amine functional compounds. Also disclosed are methodologies useful to make the ketal amide compounds. Also disclosed herein are formulations and articles containing the ketal amide compounds.

  本文披露了酮缩酸或酮缩酯与胺官能化合物反应合成的酮酰胺化合物。还披露了用于制备酮酰胺化合物的有用方法。同时还披露了含有酮酰胺化合物的配方和制品。