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2,2-dimethyl-3-hydroxy-3-phenylpropionamide | 91246-99-0

中文名称
——
中文别名
——
英文名称
2,2-dimethyl-3-hydroxy-3-phenylpropionamide
英文别名
2,2-dimethyl-3-hydroxy-3-phenylpropanamide;3-hydroxy-2,2-dimethyl-3-phenylpropanamide;3-hydroxy-2,2-dimethyl-3-phenyl-propionic acid amide;3-Hydroxy-2,2-dimethyl-3-phenyl-propionsaeure-amid
2,2-dimethyl-3-hydroxy-3-phenylpropionamide化学式
CAS
91246-99-0
化学式
C11H15NO2
mdl
——
分子量
193.246
InChiKey
CVJACRVLNVNEIY-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    0.8
  • 重原子数:
    14
  • 可旋转键数:
    3
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.36
  • 拓扑面积:
    63.3
  • 氢给体数:
    2
  • 氢受体数:
    2

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

点击查看最新优质反应信息

文献信息

  • Synthesis of β-hydroxyamides through ruthenium-catalyzed hydration/transfer hydrogenation of β-ketonitriles in water: Scope and limitations
    作者:Rebeca González-Fernández、Pascale Crochet、Victorio Cadierno
    DOI:10.1016/j.jorganchem.2019.05.016
    日期:2019.9
    A cascade process for the straightforward one-pot conversion of β-ketonitriles into β-hydroxyamides is presented. The process, that proceeds in water employing the arene-ruthenium(II) complex [RuCl2(η6-p-cymene)P(4-C6H4F)2Cl}] as catalyst in combination with sodium formate, involves the initial hydration of the β-ketonitrile substrates to generate the corresponding β-ketoamide intermediates, which
    提出了一种简单的一锅法将β-乙腈转化为β-羟酰胺的级联方法。的过程中,在水中进行采用芳烃-钌(II)络合物将[RuCl 2(η 6 - p -cymene)P(4-C 6 H ^ 4 F)2氯}]如甲酸钠催化剂组合该方法涉及β-酮腈底物的初始水合反应,以生成相应的β-酮酰胺中间体,然后对其进行羰基的转移氢化(TH)。雇用40个不同的β族-乙腈具有不同的取代模式,已经确定了该方法的范围和局限性。
  • Ruthenium-Catalyzed Synthesis of β-Hydroxyamides from β-Ketonitriles in Water
    作者:Rebeca González-Fernández、Pascale Crochet、Victorio Cadierno
    DOI:10.1021/acs.orglett.6b03172
    日期:2016.12.2
    An unprecedented hydration/transfer hydrogenation tandem process for the catalytic conversion of β-ketonitriles into synthetically useful β-hydroxyamides in water has been developed, making use of the ruthenium(II) complex [RuCl2(η6-p-cymene)P(4-C6H4F)2Cl}] in combination with sodium formate.
    对于β酮腈的催化转化成在水中合成有用β羟基酰胺前所未有的水合/转移氢化串联过程已经被开发,利用钌(II)络合物将[RuCl 2(η 6 - p -cymene)P (4-C 6 H 4 F)2 Cl}]与甲酸钠组合。
  • Chromium-mediated aldol and homoaldol reactions on solid support directed towards an iterative polyol strategy
    作者:Ludger A. Wessjohann、Harry Wild、Henri S. Schrekker
    DOI:10.1016/j.tetlet.2004.10.038
    日期:2004.11
    Chromiumn-Reformatsky and chromium-homoaldol reactions run Under neutral and mild reaction conditions. They are highly chemoselective, tolerant towards most common functional groups, and are not prone to retroaldol reactions. Initial studies directed to transfer these homogeneous chromium-mediated solution-phase reactions to solid phase are presented. The main objective was to develop a methodology to aid a combinatorial iterative strategy to polyols (polyketides) on solid phase. A general reactivity problem was observed with polystyrene based resins compared to the solution-phase reactions, independent if the electrophilic (aldehyde) or nucleophilic (bromide) end of the polyol chain was supported to the resin. A complicated penetration, or loss of the polar solvent environment after penetration into the resin, might be responsible for the reduced reactivity. Application of either a soluble polystyrene resin or a polystyrene resin with a polar polyethylene glycol tether resulted in improved yields. (C) 2004 Elsevier Ltd. All rights reserved.
  • Siwerzewa, <1958> Nr. 5, S. 9, 15
    作者:Siwerzewa
    DOI:——
    日期:——
  • Double hepatomesenteric artery a rare anatomical variant
    作者:N. Hentati、A. Pasco、H.-D. Fournier、X. Papon、P. Mercier
    DOI:10.1007/s00276-001-0285-6
    日期:2001.11
    A case of a "double hepatomesenteric artery", i.e. two persisting hepatic arteries arising from the superior mesenteric artery, is reported. Also observed was a lack of systematisation of the pancreaticoduodenal arteries. The variant, which does not appear to have been previously reported in the literature, was observed when dissecting the vessels of the duodenal bulb in a preserved male cadaver injected with neoprene latex. Its embryological origin, as well as the clinical, radiological (diagnostic or interventional) and surgical implications, are discussed.
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