2,2-dimethyl-3-hydroxy-3-phenylpropionamide | 91246-99-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2-dimethyl-3-hydroxy-3-phenylpropionamide
• 英文别名: 2,2-dimethyl-3-hydroxy-3-phenylpropanamide；3-hydroxy-2,2-dimethyl-3-phenylpropanamide；3-hydroxy-2,2-dimethyl-3-phenyl-propionic acid amide；3-Hydroxy-2,2-dimethyl-3-phenyl-propionsaeure-amid
• CAS: 91246-99-0
• 化学式: C₁₁H₁₅NO₂
• 分子量: 193.246
• InChiKey: CVJACRVLNVNEIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2-dimethyl-3-hydroxy-3-phenylpropionamide 在 potassium permanganate 作用下， 生成 2,2-dimethyl-3-oxo-3-phenyl-propionic acid amide
  参考文献：
  名称：

  Siwerzewa, <1958> Nr. 5, S. 9, 15

  摘要：

  DOI：
• 作为产物：
  描述：

  3-hydroxy-2,2-dimethyl-3-phenylpropanenitrile 在 水 、 sodium carbonate 作用下， 以 异丙醇 为溶剂， 生成 2,2-dimethyl-3-hydroxy-3-phenylpropionamide
  参考文献：
  名称：

  β-羟基羧酰胺的一锅腈腈水合/水合操作

  摘要：

  抢救铑：在基本中性的pH值和环境条件下，使用Rh I（OR）（R = H，Me）催化剂，可得到羧酰胺的正式醇醛缩合产物（CONH 2）。这种新的羟醛策略基于腈的催化羟醛型反应，然后水合腈官能团（R 1 =芳族或脂肪族，R 2和R 3 = H或烷基；参见方案）。

  DOI：

  10.1002/asia.201000921

文献信息

• Synthesis of β-hydroxyamides through ruthenium-catalyzed hydration/transfer hydrogenation of β-ketonitriles in water: Scope and limitations
  作者：Rebeca González-Fernández、Pascale Crochet、Victorio Cadierno

  DOI：10.1016/j.jorganchem.2019.05.016

  日期：2019.9

  A cascade process for the straightforward one-pot conversion of β-ketonitriles into β-hydroxyamides is presented. The process, that proceeds in water employing the arene-ruthenium(II) complex [RuCl2(η6-p-cymene)P(4-C6H4F)2Cl}] as catalyst in combination with sodium formate, involves the initial hydration of the β-ketonitrile substrates to generate the corresponding β-ketoamide intermediates, which

  提出了一种简单的一锅法将β-乙腈转化为β-羟酰胺的级联方法。的过程中，在水中进行采用芳烃-钌（II）络合物将[RuCl 2（η 6 - p -cymene）P（4-C 6 H ^ 4 F）2氯}]如甲酸钠催化剂组合该方法涉及β-酮腈底物的初始水合反应，以生成相应的β-酮酰胺中间体，然后对其进行羰基的转移氢化（TH）。雇用40个不同的β族-乙腈具有不同的取代模式，已经确定了该方法的范围和局限性。
• Ruthenium-Catalyzed Synthesis of β-Hydroxyamides from β-Ketonitriles in Water
  作者：Rebeca González-Fernández、Pascale Crochet、Victorio Cadierno

  DOI：10.1021/acs.orglett.6b03172

  日期：2016.12.2

  An unprecedented hydration/transfer hydrogenation tandem process for the catalytic conversion of β-ketonitriles into synthetically useful β-hydroxyamides in water has been developed, making use of the ruthenium(II) complex [RuCl2(η6-p-cymene)P(4-C6H4F)2Cl}] in combination with sodium formate.

  对于β酮腈的催化转化成在水中合成有用β羟基酰胺前所未有的水合/转移氢化串联过程已经被开发，利用钌（II）络合物将[RuCl 2（η 6 - p -cymene）P （4-C 6 H 4 F）2 Cl}]与甲酸钠组合。
• Chromium-mediated aldol and homoaldol reactions on solid support directed towards an iterative polyol strategy
  作者：Ludger A. Wessjohann、Harry Wild、Henri S. Schrekker

  DOI：10.1016/j.tetlet.2004.10.038

  日期：2004.11

  Chromiumn-Reformatsky and chromium-homoaldol reactions run Under neutral and mild reaction conditions. They are highly chemoselective, tolerant towards most common functional groups, and are not prone to retroaldol reactions. Initial studies directed to transfer these homogeneous chromium-mediated solution-phase reactions to solid phase are presented. The main objective was to develop a methodology to aid a combinatorial iterative strategy to polyols (polyketides) on solid phase. A general reactivity problem was observed with polystyrene based resins compared to the solution-phase reactions, independent if the electrophilic (aldehyde) or nucleophilic (bromide) end of the polyol chain was supported to the resin. A complicated penetration, or loss of the polar solvent environment after penetration into the resin, might be responsible for the reduced reactivity. Application of either a soluble polystyrene resin or a polystyrene resin with a polar polyethylene glycol tether resulted in improved yields. (C) 2004 Elsevier Ltd. All rights reserved.
• Double hepatomesenteric artery a rare anatomical variant
  作者：N. Hentati、A. Pasco、H.-D. Fournier、X. Papon、P. Mercier

  DOI：10.1007/s00276-001-0285-6

  日期：2001.11

  A case of a "double hepatomesenteric artery", i.e. two persisting hepatic arteries arising from the superior mesenteric artery, is reported. Also observed was a lack of systematisation of the pancreaticoduodenal arteries. The variant, which does not appear to have been previously reported in the literature, was observed when dissecting the vessels of the duodenal bulb in a preserved male cadaver injected with neoprene latex. Its embryological origin, as well as the clinical, radiological (diagnostic or interventional) and surgical implications, are discussed.
• Siwerzewa, 1958, # 5, p. 9,15
  作者：Siwerzewa

  DOI：——

  日期：——