4-chloro-2,6-bis(2-pyridyl)pyrimidine | 10198-68-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-chloro-2,6-bis(2-pyridyl)pyrimidine
• 英文别名: 4-Chloro-2,6-bis(2-pyridinyl)pyrimidine；4-chloro-2,6-di(2-pyridinyl)pyrimidine；4-chloro-2,6-di-pyridin-2-yl-pyrimidine；4-chloro-2,6-dipyridin-2-ylpyrimidine
• CAS: 10198-68-2
• 化学式: C₁₄H₉ClN₄
• 分子量: 268.705
• InChiKey: IGJZUIYZPXXSOR-UHFFFAOYSA-N

物化性质

• 沸点：
  366.7±42.0 °C(Predicted)
• 密度：
  1.311±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-chloro-2,6-bis(2-pyridyl)pyrimidine 、 间氨基苯甲醚 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 以60%的产率得到4-(3-Methoxyanilino)-2,6-di(2-pyridinyl)pyrimidine
  参考文献：
  名称：

  Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators or caspases and inducers of apoptosis and the use thereof

  摘要：

  本发明涉及被一般式I所代表的取代的2-芳基-4-芳基氨基嘧啶及其类似物： 其中A，Ar1，Ar2，R1和R3在此处被定义。本发明还涉及发现具有式I的化合物是caspase的激活剂和凋亡诱导剂。本发明的化合物可用于诱导在出现未受控制的异常细胞生长和扩散的各种临床病况中的细胞死亡。

  公开号：

  US20030069239A1
• 作为产物：
  描述：

  皮考林乙酸乙酯 在 氯化亚砜 、 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 72.0h， 生成 4-chloro-2,6-bis(2-pyridyl)pyrimidine
  参考文献：
  名称：

  Green-to-Red Electrochromic Fe(II) Metallo-Supramolecular Polyelectrolytes Self-Assembled from Fluorescent 2,6-Bis(2-pyridyl)pyrimidine Bithiophene

  摘要：

  The structure and properties of metallo-supramolecular polyelectrolytes (MEPEs) self-assembled from rigid 2,6-bis(2-pyridyl)pyrimidine and the metal ions Fe-II and Co-II are presented. While FeL1-MEPE (L1 = 1,4-bis[2,6-bis(2-pyridyl)pyrimidin-4-yl]benzene) is deep blue, FeL2- and CoL2-MEPE (L2 = 5,5'-bis[2,6-bis(2-pyridyl)pyrimidin-4-yl]-2,2'-bithiophene) are intense green and red in color, respectively. These novel MEPEs display a high extinction coefficient and solvatochromism. Ligand L2 shows a high absolute fluorescence quantum yield (Phi(f) = 82%). Viscosity and static light-scattering measurements reveal that the molar masses of these MEPEs are in the range of 1 x 10(8) g/mol under the current experimental conditions. In water, FeL1-MEPE forms a viscous gel at 20 degrees C (c = 8 mM). Thin films of high optical quality are fabricated by dip coating on transparent conducting indium tin oxide (ITO) glass substrate. Optical, electrochemical, and electrochromic properties of the obtained MEPEs are presented. Green to red and blue to colorless electrochromism is observed for FeL2-MEPE and FeL1-MEPE, respectively. The results show that the electrochromic properties are affected by the ligand topology. The Fe-MEPEs show a reversible redox behavior of the Fe-II/Fe-III couple at 0.86 and 0.82 V versus Fc(+)/Fc and display an excellent redox cycle stability under switching conditions. FeL2-MEPE in its oxidized state exhibits a broad absorption band covering the near-IR region (ca. 1500 nm) due to the ligand-to-metal charge transfer transition originating due to charge delocalization in the bithiophene spacer.

  DOI：

  10.1021/acs.inorgchem.6b02496

文献信息

• Triazinylpiperazinyl steroids
  申请人：The Upjohn Company

  公开号：US05380840A1

  公开（公告）日：1995-01-10

  Disclosed are amino substituted steroids (XI) which contain 4-[1,3,5-triazin-2-yl]- or 4-[1,2,4-triazin-3-yl]- 1-piperazinyl group attached to the terminal carbon atom of the C.sub.17 -side chain which are useful as pharmaceutical agents for treating a number of conditions.

  本发明涉及一种氨基取代类固醇（XI），其包含连接到C.sub.17-侧链末端碳原子的4-[1,3,5-三嗪基]-或4-[1,2,4-三嗪基]-1-哌嗪基团，这些类固醇可用作治疗多种疾病的药物。
• Pyridinylpiperazinyl steroids
  申请人：The Upjohn Company

  公开号：US05380841A1

  公开（公告）日：1995-01-10

  Disclosed are amino substituted steroids (XI) which contain a pyridinylpiperazinyl group group attached to the terminal carbon atom of the C.sub.17 -side chain of the steroid which are useful as pharmaceutical agents for treating a number of conditions.

  本发明涉及含有吡啶基哌嗪基团附着在类固醇的C.sub.17侧链的末端碳原子上的氨基取代类固醇（XI），其作为治疗多种疾病的药物代理非常有用。
• Pyrazinylpiperazinyl steroids
  申请人：The Upjohn Company

  公开号：US05382661A1

  公开（公告）日：1995-01-17

  Disclosed are amino substituted steroids (XI) which contain a pyrazinylpiperazinyl group attached to the terminal carbon atom of the C.sub.17 -side chain which are useful as pharmaceutical agents for treating a number of conditions.

  本发明涉及一种含有吡嗪基哌嗪基团附加在C.sub.17-侧链的末端碳原子上的氨基取代类固醇（XI），其作为治疗多种疾病的药物剂量形式具有应用价值。
• Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators of caspases and inducers of apoptosis and the use thereof
  申请人：Cytovia, Inc.

  公开号：US20040097503A1

  公开（公告）日：2004-05-20

  The present invention is directed to substituted 2-aryl-4-arylaminopyrimidine and analogs thereof, represented by the general Formula I: 1 wherein A, Ar 1 , Ar 2 , R 1 and R 3 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. The compounds of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

  本发明涉及取代的2-芳基-4-芳氨基嘧啶及其类似物，由通式I表示：其中A、Ar1、Ar2、R1和R3如本文所定义。本发明还涉及发现具有I式化合物的活化剂和凋亡诱导剂。本发明的化合物可用于在各种临床情况下诱导细胞死亡，其中出现了不受控制的异常细胞的生长和扩散。
• Veronica plant named ‘Allvspla’
  申请人：van den Hoogen Wilhelmus T. J.

  公开号：USPP035053P2

  公开（公告）日：2023-03-21

  A new and distinct cultivar of Veronica plant named ‘Allvspla’, characterized by its upright plant habit; moderately vigorous to vigorous growth habit and moderate growth rate; freely basal branching habit; dark green-colored leaves; freely flowering habit; hemispherical compound inflorescences with numerous light purple-colored flowers; and good performance as a garden plant and cut flower.

  一种新的、独特的婆婆纳植物品种，命名为“阿勒斯普拉”，其特征为：植株直立；生长习性适中到旺盛，生长速度适中；自由基部分枝生长习性；叶子呈深绿色；自由开花习性；半球形复合花序，有众多淡紫色花朵；在花园和切花方面表现良好。