3-chlorobenzyl propionate | 85262-91-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-chlorobenzyl propionate
• 英文别名: (3-Chlorophenyl)methyl propanoate；(3-chlorophenyl)methyl propanoate
• CAS: 85262-91-5
• 化学式: C₁₀H₁₁ClO₂
• 分子量: 198.649
• InChiKey: SJYCNGGNOLTJHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-氯苯甲醇 、 丙酸乙酯 在 basic alumina 作用下， 反应 2.0h， 以71%的产率得到3-chlorobenzyl propionate
  参考文献：
  名称：

  Solvent-free transesterification in a ball-mill over alumina surface

  摘要：

  An efficient procedure for transesterification has been developed in a ball-mill in the absence of any solvent, acid/base or metal catalyst. A variety of methyl, ethyl, allyl esters have been transesterified to higher benzyl and other esters in high yields by this procedure. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.05.127

文献信息

• DUAL-ACTING ANTIHYPERTENSIVE AGENTS
  申请人：Allegretti Paul

  公开号：US20120264752A1

  公开（公告）日：2012-10-18

  The invention is directed to compounds having the formula: wherein: Ar, r, Y, Z, Q, W, X, and R 5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT 1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

  本发明涉及具有以下公式的化合物：其中：Ar、r、Y、Z、Q、W、X和R5-7如规范中所定义，并且其药学上可接受的盐。这些化合物具有AT1受体拮抗活性和神经肽酶抑制活性。本发明还涉及包含这些化合物的制药组合物；使用这些化合物的方法；以及制备这些化合物的过程和中间体。
• US8895755B2
  申请人：——

  公开号：US8895755B2

  公开（公告）日：2014-11-25
• Solvent-free transesterification in a ball-mill over alumina surface
  作者：Tanmay Chatterjee、Debasree Saha、Brindaban C. Ranu

  DOI：10.1016/j.tetlet.2012.05.127

  日期：2012.8

  An efficient procedure for transesterification has been developed in a ball-mill in the absence of any solvent, acid/base or metal catalyst. A variety of methyl, ethyl, allyl esters have been transesterified to higher benzyl and other esters in high yields by this procedure. (C) 2012 Elsevier Ltd. All rights reserved.