2-(喹啉-6-氧基)乙酸 | 103906-06-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(喹啉-6-氧基)乙酸
• 英文名称: 2-(quinolin-6-yloxy)acetic acid
• 英文别名: Chinolyl-(6)-oxy-essigsaeure；[6]quinolyloxy-acetic acid；[6]Chinolyloxy-essigsaeure；2-quinolin-6-yloxyacetic acid
• CAS: 103906-06-5
• 化学式: C₁₁H₉NO₃
• 分子量: 203.197
• InChiKey: UVBULUOHBHWKFA-UHFFFAOYSA-N

物化性质

• 沸点：
  404.1±20.0 °C(Predicted)
• 密度：
  1.337±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  59.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(喹啉-6-氧基)乙酸 在 三乙胺 、 N,N-二异丙基乙胺 、 亚磷酸二乙酯 、 间氯过氧苯甲酸 、 N,N'-羰基二咪唑 作用下， 以 四氯化碳 、 二氯甲烷 、 甲苯 、 乙腈 为溶剂， 反应 38.5h， 生成 Ethyl 2-[7-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]furo[3,2-f]quinolin-1-yl]acetate
  参考文献：
  名称：

  EP3848363

  摘要：

  公开号：
• 作为产物：
  描述：

  tert-butyl 2-(quinolin-6-yloxy)acetate 在 盐酸 作用下， 以 乙酸乙酯 为溶剂， 反应 12.0h， 生成 2-(喹啉-6-氧基)乙酸
  参考文献：
  名称：

  EP3848363

  摘要：

  公开号：

文献信息

• NOVEL TRIPEPTIDE COMPOUNDS AND ANTI-AIDS DRUGS
  申请人：JAPAN ENERGY CORPORATION

  公开号：EP0900566A1

  公开（公告）日：1999-03-10

  A novel tripeptide compound represented by the following general formula (I) exhibiting superior HIV protease inhibition activity, and an anti-AIDS medicine comprising this compound as an effective component and a pharmaceutically acceptable salt thereof. (R)-N-(2-methylbenzyl)-3-(2S,3S)-3-[N-(2-chromonecarbonyl)-L-asparaginyl]amino-2-hydroxy-4-phenylbutanoyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxamide can be given as a typical example of this compound.

  一种由以下通式(I)代表的新型三肽化合物，具有优异的抑制HIV蛋白酶活性，以及一种以该化合物为有效成分的抗艾滋病药物及其药学上可接受的盐。 (R)-N-(2-甲基苄基)-3-(2S,3S)-3-[N-(2-铬羰基)-L-天冬酰胺基]氨基-2-羟基-4-苯基丁酰基}-5,5-二甲基-1,3-噻唑烷-4-甲酰胺可作为该化合物的典型实例。
• FUSED IMIDAZOLE COMPOUND HAVING INDOLEAMINE 2,3-DIOXYGENASE INHIBITORY ACTIVITY
  申请人：Shenzhen Chipscreen Biosciences Co., Ltd.

  公开号：EP3560928A1

  公开（公告）日：2019-10-30

  The invention discloses a type of fused imidazole compound, preparation method and application thereof. The structure of the compound is shown in general formula I. The definition of each group therein is as described in the specification. These compounds are capable of selectively inhibiting indoleamine 2,3-dioxygenase (IDO). The compounds can act as an IDO inhibitor for treating and/or preventing a disease having a pathological feature with IDO-mediated tryptophan metabolic pathways, for example, cancer, eye disease, autoimmune disease, psychological disorder, depression symptom, anxiety disorder and other diseases.

  本发明公开了一种融合咪唑化合物及其制备方法和应用。该化合物的结构如通式 I 所示。其中各基团的定义如说明书所述。这些化合物能够选择性地抑制吲哚胺 2,3-二氧化酶（IDO）。这些化合物可作为 IDO 抑制剂，用于治疗和/或预防具有 IDO 介导的色氨酸代谢途径病理特征的疾病，例如癌症、眼病、自身免疫性疾病、心理障碍、抑郁症状、焦虑症和其他疾病。
• Fused imidazole compound having indoleamine 2,3-dioxygenase inhibitory activity
  申请人：SHENZHEN CHIPSCREEN BIOSCIENCES CO., LTD.

  公开号：US10604529B2

  公开（公告）日：2020-03-31

  The invention discloses a type of fused imidazole compound, preparation method and application thereof. The structure of the compound is shown in general formula I. The definition of each group therein is as described in the specification. These compounds are capable of selectively inhibiting indoleamine 2,3-dioxygenase (IDO). The compounds can act as an IDO inhibitor for treating and/or preventing a disease having a pathological feature with IDO-mediated tryptophan metabolic pathways, for example, cancer, eye disease, autoimmune disease, psychological disorder, depression symptom, anxiety disorder and other diseases.

  本发明公开了一种融合咪唑化合物及其制备方法和应用。该化合物的结构如通式 I 所示。其中各基团的定义如说明书所述。这些化合物能够选择性地抑制吲哚胺 2,3-二氧化酶（IDO）。这些化合物可作为 IDO 抑制剂，用于治疗和/或预防具有 IDO 介导的色氨酸代谢途径病理特征的疾病，例如癌症、眼病、自身免疫性疾病、心理障碍、抑郁症状、焦虑症和其他疾病。
• Strong positive cooperativity in binding to the A3T3 repeat by Hoechst 33258 derivatives attaching the quinoline units at the end of a branched linker
  作者：Hironori Koda、John Alan Brazier、Ippei Onishi、Shigeki Sasaki

  DOI：10.1016/j.bmc.2015.05.056

  日期：2015.8

  Hoechst 33258 derivatives with additional interacting moieties attached at the ends of branched linkers were synthesized, and their DNA binding properties were investigated with regard to the A3T3 repeat by measuring fluorescence spectra. The binding property of the ligand was investigated by fluorescence titration, and the titration data were analyzed using the McGhee-von Hippel method. Ligand 6Q with the quinolin-6-yloxyacetyl group and Ligand IQ with isoquinolin-6-yloxyacetyl group at the ends of the branched linkers exhibit highly positive cooperativity for the DNA having 5 A3T3 sites with 3 base-insertions between them with sequence selectivity. The strategy developed in this study may be generally applicable for designing ligands for repetitive DNA sequences. (C) 2015 Elsevier Ltd. All rights reserved.
• Moszew; Mirek, Roczniki Chemii, 1959, vol. 33, p. 365,367
  作者：Moszew、Mirek

  DOI：——

  日期：——