1,6-Bis(propionyloxy)hexane | 6222-18-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,6-Bis(propionyloxy)hexane
• 英文别名: hexane-1,6-diyl dipropionate；1,6-Bis-propionyloxy-hexan；Hexane-1,6-diyl dipropanoate；6-propanoyloxyhexyl propanoate
• CAS: 6222-18-0
• 化学式: C₁₂H₂₂O₄
• 分子量: 230.304
• InChiKey: RZOTVHJYCPTNCM-UHFFFAOYSA-N

物化性质

• 沸点：
  300.2±25.0 °C(Predicted)
• 密度：
  0.985±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 silicon carbide 作用下， 生成 1,6-Bis(propionyloxy)hexane
  参考文献：
  名称：

  US2773895

  摘要：

  公开号：

文献信息

• N-Heterocyclic Carbene-Catalyzed Chemoselective Monoacylation of 1,<i>n</i>-Linear Diols
  作者：Takahiro Soeta、Kota Kaneta、Yuichi Hatanaka、Tomonori Ida、Yutaka Ukaji

  DOI：10.1021/acs.orglett.1c02749

  日期：2021.11.5

  discusses the N-heterocyclic carbene (NHC)-catalyzed redox monoacylation of 1,n-linear diols using α-benzoyloxyaldehydes. The reactions afforded monoacylated diols in moderate to good selectivities and chemical yields. Our original NHC bearing a pyridine moiety plays an important role in achieving good chemoselectivities. A wide range of 1,n-linear diols were successfully applied to this reaction.

  本文讨论了使用 α-苯甲酰氧醛对 1, n-线性二醇进行N-杂环卡宾 (NHC) 催化氧化还原单酰化反应。该反应以中等至良好的选择性和化学产率提供单酰化二醇。我们带有吡啶部分的原始 NHC 在实现良好的化学选择性方面发挥着重要作用。广泛的 1, n-线性二醇成功应用于该反应。
• Convenient Selective Monoacylation of 1,n-Diols Catalyzed by Ion-Exchange Resins
  作者：Takeshi Nishiguchi、Shizuo Fujisaki、Yasuhiro Ishii、Yoshihiro Yano、Akiko Nishida

  DOI：10.1021/jo00084a043

  日期：1994.3

  Several 1,n-diols, ranging from 1,2-ethanediol to 1,16-hexadecanediol, were selectively monoacylated by transesterification in ester/octane solvent mixtures catalyzed by strongly acidic ion-exchange resins. This method of selective esterification is quite simple and practical. The selectivity for monoester formation and initial rates of monoester formation depended on the ester/octane ratio of the solvents. The reasons for the selectivity are as follows: (1) The sulfonic acid-type ion-exchange resins usually contain 50-80% water, and a strongly acidic aqueous layer is formed on the surface of the resins. (2) A partition equilibrium between the aqueous layer and the aprotic ester/octane layer is setup, and diols have higher partition coefficients than the product monoesters. (3) Acylation of the alcohols occurs in the aqueous layer and/or at the interface between the aqueous and the nonaqueous liquid layer. (4) The formed monoesters move away from the aqueous layer into the aprotic layer.
• BIODEGRADABLE POLY(BETA-AMINO ESTERS) AND USES THEREOF
  申请人：MASSACHUSETTS INSTITUTE OF TECHNOLOGY

  公开号：EP1639029B1

  公开（公告）日：2007-07-11
• US2773895
  申请人：——

  公开号：——

  公开（公告）日：——