2-(异丁硫基)-1H-苯并咪唑 | 75080-14-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: 2-(异丁硫基)-1H-苯并咪唑
• 英文名称: 2-isobutylmercapto-1H-benzimidazole
• 英文别名: 2-Isobutylmercapto-1H-benzimidazol；2-(Isobutylthio)-1H-benzimidazole；2-(2-methylpropylsulfanyl)-1H-benzimidazole
• CAS: 75080-14-7
• 化学式: C₁₁H₁₄N₂S
• mdl: MFCD00464037
• 分子量: 206.312
• InChiKey: BIXYBNXEZARYML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  54
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-cyclohexylbenzimidazo<1,2-d><1,2,4>thiadiazol-3(2H)-one 在 magnesium 作用下， 反应 3.0h， 生成 2-(异丁硫基)-1H-苯并咪唑
  参考文献：
  名称：

  Tittelbach, Franz; Martin, Dieter, Journal fur praktische Chemie (Leipzig 1954), 1988, vol. 330, # 3, p. 338 - 348

  摘要：

  DOI：

文献信息

• Fluorenone derivatives, process for preparing the same and central or peripheral nerve degeneration repair and protective agent
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0791570A1

  公开（公告）日：1997-08-27

  The present invention provides novel fluorenone derivatives represented by formula (A) (wherein Ra-Rg are defined in the specification), and a method for repairing and protecting central or peripheral nerve degeneration comprising use of a fluorenone derivative represented by formula (1) (wherein R1, R2, p and q are as defined in the specification) as an active component.

  本发明提供了式(A)代表的新型芴酮衍生物（其中Ra-Rg在说明书中定义），以及一种修复和保护中枢或周围神经变性的方法，包括使用式(1)代表的芴酮衍生物（其中R1、R2、p和q在说明书中定义）作为活性成分。
• Nakajima et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1958, vol. 78, p. 1378,1381
  作者：Nakajima et al.

  DOI：——

  日期：——
• Knobloch et al., Archiv der Pharmazie, 1958, vol. 291, p. 113,114
  作者：Knobloch et al.

  DOI：——

  日期：——
• Synthesis and preliminary evaluation of benzimidazole derivatives as antimicrobial agents
  作者：Věra Klimešová、Jan Kočı́、Milan Pour、Jiřı́ Stachel、Karel Waisser、Jarmila Kaustová

  DOI：10.1016/s0223-5234(02)01342-9

  日期：2002.5

  A series of 2-alkylsulphanylbenzimidazoles was synthesised and the compounds were evaluated for their in vitro antimicrobial activity. The structures of the compounds were confirmed by H-1-NMR and IR data, and their purity by elemental analysis. Antimycobacterial activities against Mycobacterium tuberculosis and non-tuberculous mycobacteria as well as antifungal activities against Candida albicans, Candida tropicalis, Candida krusei, Candida glabrata, Trichosporon beigelii, Trichophyton mentagrophytes and Aspergillus fumigatus were expressed as the corresponding MIC values. The substances exhibited appreciable antimycobacterial activity, in particular, against non-tuberculous mycobacteria. The activity of the most active compound in the set, 3,5-dinitro derivative 4t, exceeded that of the standard isoniazide against M. kansasii and M. avium. The antifungal activities of the compounds were relatively low. A weak antifungal effect was observed against the dermatophyte Trichophyton mentagrophytes. None of the compounds showed significant inhibitory activity against yeasts. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
• TITTELBACH, FRANZ;MARTIN, DIETER, J. PRAKT. CHEM., 330,(1988) N 3, C. 338-348
  作者：TITTELBACH, FRANZ、MARTIN, DIETER

  DOI：——

  日期：——