2-(氨基)油酸 | 56472-43-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-(氨基)油酸
• 英文名称: 2-Amino oleic acid
• 英文别名: (Z)-2-aminooctadec-9-enoic acid
• CAS: 56472-43-6
• 化学式: C₁₈H₃₅NO₂
• 分子量: 297.5
• InChiKey: ODURFHDFZAVGHC-KTKRTIGZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• USE OF HYDROXYOLEIC ACID AND SIMILAR COMPOUNDS IN THE PRODUCTION OF MEDICAMENTS
  申请人：Universitat de les Illes Balears

  公开号：EP1435235A1

  公开（公告）日：2004-07-07

  Use of hydroxyoleic acid and its analogous compounds in the manufacture of drugs. Describes the use of hydroxyoleic acid and its analogs of general formula I: COOH-CHR-(CH2)m-CH=CH-(CH2)n-CH3, in which m and n have, independently, a value of 0-15 and R can be any residue with molecular weight below 200 Da, in the manufacture of drugs that can be used in the treatment of cancer, hypertension, obesity or diseases mediated by alteration of the membrane structure and the consequent regulation of G-proteins or of the receptors coupled to them.

  使用羟基油酸及其类似化合物制造药物。描述了羟基油酸及其通式 I 类似物的用途：COOH-CHR-(CH2)m-CH=CH-( )n-CH3，其中m和n的值分别为0-15，R可以是分子量低于200Da的任何残基。
• Method of preparing acellularized, biocompatible, implantable material
  申请人：Tecnobiomedica S.p.A.

  公开号：EP1719533A1

  公开（公告）日：2006-11-08

  The present invention relates to new method of preparing acellularized, biocompatible, implantation material starting from a biological material. In particular, the present invention relates to a method of preparing biological material for implantation comprising (a) fixation with an aldehyde the biological material and (b) detoxification/anticalcification of the fixed biological material, wherein the detoxification/anticalcification step makes use of a novel class of substances of formula:          NH2- (CH2)n-X     (I) wherein X is COOH, SO3H, PO3H2 and n is an integer from 2 to 6.

  本发明涉及从生物材料开始制备细胞化、生物相容性植入材料的新方法。特别是，本发明涉及一种制备植入用生物材料的方法，该方法包括：(a) 用醛固定生物材料；(b) 对固定的生物材料进行解毒/抗钙化，其中解毒/抗钙化步骤使用了一类新型的式物质： NH2- (CH2)n-X (I) 其中 X 是 COOH、SO3H、PO3H2 和 n 是 2 至 6 的整数。
• Method for producing improved medical devices and devices so produced
  申请人：——

  公开号：US20010012538A1

  公开（公告）日：2001-08-09

  Medical devices and methods of producing same are provided. The medical device comprising a body member and a coating on at least a portion of the body member comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight polyoxyalkylene derivative.

  提供了医疗器械及其生产方法。医疗设备包括一个主体部件和主体部件至少一部分上的涂层，涂层包括第一种亲电活性高分子量聚氧化烯和第二种高分子量聚氧亚烷基衍生物的原位缩合产物。
• Tris(hydroxymethyl)phosphino compounds as tissue crosslinking agents
  申请人：——

  公开号：US20020111532A1

  公开（公告）日：2002-08-15

  A method of cross-linking a tissue, comprising treating the tissue under effective cross-linking conditions with a fluid comprising a compound comprising P(CH 2 OH) 3 X n , wherein X is selected from C 1 -C 10 carboxyl, sulfonic acid, sulfonic acid salts, C 1 -C 10 alcohol, or halogens, and n is an integer from 0 to 2, inclusive, and all —X and —CH 2 OH groups are bonded to the phosphorus atom. In one embodiment, the compound is &bgr;-(tris(hydroxymethyl)phosphino)proprionic acid (THPP). Also disclosed is a cross-linked biological tissue produced by treating the tissue according to the above method.

  一种交联组织的方法，包括在有效的交联条件下，用一种包含 P(CH2)和 P(CH3)的化合物的流体处理组织。 2 OH） 3 X n 其中 X 选自 C 1 -C 10 羧基、磺酸、磺酸盐、C 1 -C 10 醇或卤素，且 n 为 0 至 2（包括 2）的整数，所有 -X 和 -CH 2 OH基团都键合在磷原子上。在一个实施方案中，该化合物是&bgr;-(三(羟甲基)膦)丙酸（THPP）。 本发明还公开了一种交联生物组织，该组织是根据上述方法处理后产生的。
• Diunsaturated organic compounds as tissue crosslinking agents
  申请人：——

  公开号：US20020119563A1

  公开（公告）日：2002-08-29

  Herein is disclosed a method of cross-linking a tissue, comprising treating the tissue under effective cross-linking conditions with a diunsaturated organic compound comprising structure I: 1 wherein R, R′, and R″ are each independently an organic moiety having from 1 to 20 carbon atoms. Also disclosed is a cross-linked biological tissue produced by treating the tissue according to the above method.

  本发明公开了一种交联组织的方法，包括在有效的交联条件下用包含结构 I 的二不饱和有机化合物处理组织： 1 其中 R、R′和 R″ 各自独立地为具有 1 至 20 个碳原子的有机分子。 本发明还公开了一种交联生物组织，该组织是根据上述方法处理后产生的。