trans-cyclobutane-1,2-dicarbonyl dichloride | 3668-43-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: trans-cyclobutane-1,2-dicarbonyl dichloride
• 英文别名: trans-1,2-cyclobutanedicarboxylic acid；(1S,2S)-cyclobutane-1,2-dicarbonyl chloride
• CAS: 3668-43-7；45775-91-5；45775-94-8；89380-29-0
• 化学式: C₆H₆Cl₂O₂
• 分子量: 181.018
• InChiKey: UKHMRFDNOROHOX-IMJSIDKUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  trans-cyclobutane-1,2-dicarbonyl dichloride 在 sodium azide 作用下， 以 苯 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  The synthesis and use in asymmetric epoxidation of metal salen complexes derived from enantiopure trans-cyclopentane- and cyclobutane-1,2-diamine

  摘要：

  A complete synthesis of enantiopure trans-cyclopentane-1,2-diamine and trans-cyclobutane-1,2-diamine is described. These diamines have been used as components of novel chiral salen ligands whose chromium and manganese complexes were then evaluated as oxygen transfer agents in the asymmetric epoxidation of alkenes. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(02)00757-7
• 作为产物：
  描述：

  dimethyl 1-cyanocyclobutane-1,2-dicarboxylate 在 盐酸 、 氯化亚砜 作用下， 以 苯 为溶剂， 反应 36.0h， 生成 trans-cyclobutane-1,2-dicarbonyl dichloride
  参考文献：
  名称：

  The synthesis and use in asymmetric epoxidation of metal salen complexes derived from enantiopure trans-cyclopentane- and cyclobutane-1,2-diamine

  摘要：

  A complete synthesis of enantiopure trans-cyclopentane-1,2-diamine and trans-cyclobutane-1,2-diamine is described. These diamines have been used as components of novel chiral salen ligands whose chromium and manganese complexes were then evaluated as oxygen transfer agents in the asymmetric epoxidation of alkenes. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(02)00757-7

文献信息

• Aminimides. I. A general synthesis of aminimides from acyl hydrazides and their pyrolysis
  作者：William J. McKillip、Lawrence M. Clemens、Richard Haugland

  DOI：10.1139/v67-424

  日期：1967.11.1

  Acyclic, alicyclic, and aromatic bis-trimethylaminimides and a keto-substituted trimethylaminimide have been synthesized by a stepwise route of general applicability. Pyrolysis of the aliphatic aminimides resulted in a rearrangement to trimethylamine and isocyanate. The keto-isocyanate herein reported was synthesized in a convenient four-step sequence from dimethyl ketene dimer in a good yield, and provides an attractive new route to this type of difunctional compound. Pyrolysis of the bis-aminimides in the presence of polyhydroxylic materials gave polyurethanes.

  无环、脂环和芳香族双三甲基胺亚胺以及一种酮取代的三甲基胺亚胺已通过一种普遍适用的分步路线合成。脂肪族胺亚胺的热解导致重排生成三甲胺和异氰酸酯。本文报道的酮异氰酸酯是从二甲基酮二聚体经过方便的四步序列以较高产率合成的，并为这种二官能化合物提供了一条有吸引力的新途径。在多羟基材料存在下，双胺亚胺的热解产生聚氨酯。
• Hypocholesterolemic agents III: Inhibition of β‐hydroxy‐β‐methylglutaryl coenzyme a reductase by half acid esters of 1‐(4‐biphenylyl)pentanol
  作者：Kenneth E. Guyer、Sharon G. Boots、Paul E. Marecki、Marvin R. Boots

  DOI：10.1002/jps.2600650417

  日期：1976.4

  A series of half acid esters of 1-(4-biphenylyl)pentanol was synthesized and assayed for inhibition of rat liver beta-hydroxy-beta-methylglutaryl coenzyme A reductase. The number of methylenes separating the carboxyl and ester groups was varied from zero to six. A minimum of one methylene was required for reasonable activity. Further separation of the carboxyl and ester groups produced small changes

  合成了一系列1-（4-联苯基）戊醇的半酸酯，并测定了对大鼠肝脏β-羟基-β-甲基戊二酰辅酶A还原酶的抑制作用。分离羧基和酯基的亚甲基的数量从零到六不等。为了合理的活性，最少需要一种亚甲基。羧基和酯基的进一步分离产生小的活性变化。对几种异构（顺式和反式）半酸酯的研究表明，活性与构型无关。通过掺入3-羟基对戊二酸类似物的酸部分进行的修饰使活性增加了六倍。
• [EN] HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF<br/>[FR] COMPOSÉS HÉTÉROARYLES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：SUNOVION PHARMACEUTICALS INC

  公开号：WO2013192273A1

  公开（公告）日：2013-12-27

  Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

  本文提供了杂环芳基化合物，其合成方法，包含这些化合物的药物组合物，以及它们的使用方法。在一个实施例中，本文提供的化合物可用于治疗、预防和/或管理各种疾病，如中枢神经系统疾病和代谢性疾病，包括但不限于神经系统疾病、精神病、精神分裂症、肥胖症和糖尿病。
• HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF
  申请人：SUNOVION PHARMACEUTICALS INC.

  公开号：US20150322090A1

  公开（公告）日：2015-11-12

  Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

  本文提供了杂环芳基化合物、它们的合成方法、包含这些化合物的药物组成物，以及它们的使用方法。在一个实施例中，本文提供的化合物可用于治疗、预防和/或管理各种疾病，例如中枢神经系统疾病和代谢性疾病，包括但不限于神经系统疾病、精神病、精神分裂症、肥胖症和糖尿病。
• MANUFACTURING METHOD FOR TRIPTYCENE POLYMER CARRIER FILM
  申请人：Nanjing Tech University

  公开号：EP3323500A1

  公开（公告）日：2018-05-23

  The Invention discloses a preparation method for a triptyl polymer separation membrane, wherein, it comprises the following steps: take triptycene compound containing active group, dichloride compound and diamino compound containing ether bond as monomers, and conduct polymerization in aprotic organic solvent in the presence of acid-binding agent; pour the obtained polymer solution into deionized water for precipitation after the reaction, filter out precipitates and wash with methanol and dry to get triptyl polymer; dissolve the triptyl polymer in aprotic organic solvent to produce a membrane-casting solution, apply the solution on support and dry to get a triptyl polymer separation membrane. The Invention solves the problem that the reticular polymer material is insoluble, and breaks the restriction for application of such material in separation membrane due to its insoluble and aging features.

  本发明公开了一种三庚基聚合物分离膜的制备方法，包括以下步骤：以含活性基团的三庚烯化合物、二氯化物和含醚键的二氨基化合物为单体，在酸结合剂存在下，在非沸点有机溶剂中进行聚合反应；反应后将得到的聚合物溶液倒入去离子水中沉淀，过滤出沉淀物，用甲醇洗涤并干燥，得到三庚基聚合物；将三庚基聚合物溶解在非沸点有机溶剂中，制得铸膜溶液，将溶液涂覆在支撑体上，干燥，得到三庚基聚合物分离膜。本发明解决了网状高分子材料不溶性的问题，打破了网状高分子材料因其不溶性和老化性而应用于分离膜的限制。