6-phenyl-lumazine | 50996-22-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: 6-phenyl-lumazine
• 英文别名: 6-phenyllumazine；6-phenyl-1H-pteridine-2,4-dione；6-Phenyl-1H-pteridin-2,4-dion；2,4-Dioxo-6-phenyl-pteridin；6-Phenyllumazin；6-phenyl-1H-pteridine-2,4-dione
• CAS: 50996-22-0
• 化学式: C₁₂H₈N₄O₂
• 分子量: 240.221
• InChiKey: IQRSMPZIFOZXEK-UHFFFAOYSA-N

物化性质

• 熔点：
  380-382 °C
• 密度：
  1.56±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  84
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-phenyl-lumazine 在 对甲苯磺酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 0.25h， 生成 6-phenyl-1-(2-deoxy-β-D-ribofuranosyl)lumazine
  参考文献：
  名称：

  Nucleosides, LVIII¹ Synthesis of Base - Modified Oligonucleotides Containing 6- and 7-Aryl Lumazines

  摘要：

  6-Phenyl-, 7-phenyl-, 6-(4-biphenyl)-7-(4-biphenyl)lumazine N-1-2-deoxy-beta-D-ribofuranosides were synthesized, then converted into the corresponding 5'-O-dimethoxytrityl-3'-O-(beta-cyanoethyl, N,N-diisopropyl)phosphoramidites and incorporated into different positions of self-complementary oligonucleotides. The influence of modifications on the melting temperature of the resulting duplexes was studied.

  DOI：

  10.1080/07328319608002396
• 作为产物：
  描述：

  2-异亚硝基苯乙酮 在 Arthrobacter xanthine oxidase 作用下， 以 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 反应 180.42h， 生成 6-phenyl-lumazine
  参考文献：
  名称：

  Meester, Johan W. G. De; Plas, Henk C. van der; Middelhoven, Wouter J., Journal of Heterocyclic Chemistry, 1987, vol. 24, p. 441 - 451

  摘要：

  DOI：

文献信息

• Determination of Triazines in Water Samples by High-Performance Liquid Chromatography with Diode-Array Detection
  作者：M. S. Dopico、M. V. Gonzalez、J. M. Castro、E. Gonzalez、J. Perez、M. Rodriguez、A. Calleja

  DOI：10.1093/chromsci/40.9.523

  日期：2002.10.1

  Triazines are widely used herbicides that can be detected in the environment at trace level. A preconcentration step is necessary to determinate them before analysis. In this study, carbonaceous and polymeric adsorbents are compared with C18 for the solid-phase extraction of simazine, atrazine, and propazine in water samples in order to quantitate their levels by high-performance liquid chromatography using photodiode-array detection.

  三嗪类除草剂广泛使用，可在环境中以痕量水平被检测到。分析前需要一个预浓集步骤。本研究中，比较了炭质和聚合物吸附剂与C18在固相萃取水中西玛津、阿特拉津和扑灭津的效果，以便通过使用光电二极管阵列检测的高性能液相色谱法定量它们的含量。
• Process for manufacturing purified phosphorodiamidite
  申请人：——

  公开号：US20030225284A1

  公开（公告）日：2003-12-04

  A scalable process for purification of phosphorodiamidite includes steps of solubilizing a crude phosphorodiamidite in an apolar organic solvent, contacting the non-polar organic solvent with a polar phase comprising a polar organic solvent to remove impurities from the solubilized phosphorodiamidite, and removing the non-polar organic solvent from the phosphorodiamidite.

  一种用于纯化磷酰二胺基的可扩展过程包括以下步骤：将粗磷酰二胺基溶解在非极性有机溶剂中，将非极性有机溶剂与含有极性有机溶剂的极性相接触，以从溶解的磷酰二胺基中去除杂质，并将非极性有机溶剂从磷酰二胺基中去除。
• Solvent-free regioselective synthesis of 6-and 7-substituted pteridines under microwave irradiation
  作者：R. Singh、Geetanjali

  DOI：10.1134/s1070428006010210

  日期：2006.1

  Reactions of 5,6-diaminouracils with a-keto aldehydes over acidic and neutral aluminum oxide under microwave irradiation gave the corresponding 6- and 7-substituted 1,2,3,4-tetrahydropteridine-2,4-diones in 63-79% yield with high regioselectivity.
• Angier, Journal of Organic Chemistry, 1963, vol. 28, p. 1398,1400
  作者：Angier

  DOI：——

  日期：——
• YONEDA F.; HIGUCHI M., J. CHEM. SOC. PERKIN TRANS., PART 1 <JCPK-BH>, 1977, NO 11, 1336-1339
  作者：YONEDA F.、 HIGUCHI M.

  DOI：——

  日期：——