propanesulfonic anhydride | 82452-54-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: propanesulfonic anhydride
• 英文别名: Propylsulfonyl propane-1-sulfonate
• CAS: 82452-54-8
• 化学式: C₆H₁₄O₅S₂
• 分子量: 230.306
• InChiKey: OTRCLINFKXQIBG-UHFFFAOYSA-N

物化性质

• 沸点：
  335.2±11.0 °C(Predicted)
• 密度：
  1.308±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  94.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-amino-8-methoxy-3-methyl-1-propyl-imidazo[1,5-a]pyrido[3,2-e]pyrazine 、 propanesulfonic anhydride 在 三乙胺 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以81%的产率得到8-methoxy-3-methyl-4-propylsulfonylamino-1-propyl-imidazo[1,5-a]pyrido[3,2-e]pyrazine
  参考文献：
  名称：

  Discovery of Imidazo[1,5-a]pyrido[3,2-e]pyrazines as a New Class of Phosphodiesterase 10A Inhibitiors

  摘要：

  Novel imidazo[1,5-a]pyrido[3,2-e]pyrazines have been synthesized and characterized as both potent and selective phosphodiesterase 10A (PDE10A) inhibitors. For in vitro characterization, inhibition of PDE10A mediated cAMP hydrolysis was used and a QSAR model was established to analyze substitution effects. The outcome of this analysis was complemented by the crystal structure of PDE10A in complex with compound 49. Qualitatively new interactions between inhibitor and binding site were found, contrasting with previously published crystal structures of papaverine-like inhibitors. In accordance with the known antipsychotic potential of PDE10A inhibitors, MK-801 induced stereotypy and hyperactivity in rats were reversed by selected compounds. Thus, a promising compound class has been identified for the treatment of schizophrenia that could circumvent side effects connected with current therapies.

  DOI：

  10.1021/jm1002793
• 作为产物：
  描述：

  二丙基二硫 在 dinitrogen tetraoxide 作用下， 以 四氯化碳 为溶剂， 生成 propanesulfonic anhydride
  参考文献：
  名称：

  The Reaction of Disulfide with Dinitrogen Tetroxide

  摘要：

  DOI：

  10.1246/bcsj.41.233

文献信息

• Photoacid generators, chemically amplified resist compositions, and patterning process
  申请人：Ohsawa Youichi

  公开号：US20070292768A1

  公开（公告）日：2007-12-20

  A photoacid generator has formula (1). A chemically amplified resist composition comprising the photoacid generator has advantages including a high resolution, focus latitude, long-term PED dimensional stability, and a satisfactory pattern profile shape. When the photoacid generator is combined with a resin having acid labile groups other than those of the acetal type, resolution and top loss are improved. The composition is suited for deep UV lithography.

  一种光酸发生剂的化学式为（1）。包括该光酸发生剂的化学增感抗蚀组合物具有诸如高分辨率、焦点宽度、长期PED尺寸稳定性和令人满意的图案轮廓形状等优点。当该光酸发生剂与具有除了缩醛类型以外的酸敏感基团的树脂结合时，可以改善分辨率和顶部损失。该组合物适用于深紫外光刻。
• Fungal efflux pump inhibitors
  申请人：——

  公开号：US20030220338A1

  公开（公告）日：2003-11-27

  This invention relates to compounds that are efflux pump inhibitors and therefore are useful as potentiators of anti-fungal agents for the treatment of infections caused by fungi that employ an efflux pump resistance mechanism.

  这项发明涉及一类外流泵抑制剂化合物，因此可作为抗真菌药物的增效剂，用于治疗由利用外流泵抗性机制的真菌引起的感染。
• METHOD FOR PREPARING AN AROMATIC SULFIDE OR SALT THEREOF
  申请人：INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

  公开号：US20170197914A1

  公开（公告）日：2017-07-13

  A method for preparing an aromatic sulfide or a salt thereof is provided. The method for preparing an aromatic sulfide or a salt thereof includes reacting a compound having a structure represented by Formula (I) to a compound having a structure represented by Formula (III) in the presence of a compound having a structure represented by Formula (II) to obtain a compound having a structure represented by Formula (IV) wherein R 1 and R 2 are independently C 1-6 alkyl group, or C 5-7 cycloalkyl group; R 3 is independently C 1-6 alkyl group, C 5-7 cycloalkyl group, C 1-6 haloalkyl group, or aryl group; R 4 is independently H, or C 1-6 alkyl group; Y is H, aryl group, or —X—R 5 ; X is —O—, —NH—, —PH—, or —S—, or Y and an adjacent R 4 are optionally combined with the carbon atoms to which they are attached, to form an aryl group; and R 5 is H, C 1-6 alkyl group, C 5-7 cycloalkyl group, or aryl group; and Z − is R 3 SO 3 − .

  提供一种制备芳香硫醚或其盐的方法。制备芳香硫醚或其盐的方法包括在具有由式（I）表示的结构的化合物存在下，将具有由式（III）表示的结构的化合物与具有由式（II）表示的结构的化合物反应，以获得具有由式（IV）表示的结构的化合物，其中R1和R2分别为C1-6烷基基团或C5-7环烷基基团；R3独立为C1-6烷基基团、C5-7环烷基基团、C1-6卤代烷基基团或芳基；R4独立为H或C1-6烷基基团；Y为H、芳基或—X—R5；X为—O—、—NH—、—PH—或—S—，或Y和相邻的R4可选择性地与它们连接的碳原子结合，形成芳基；R5为H、C1-6烷基基团、C5-7环烷基基团或芳基；Z-为R3SO3-。
• METHOD FOR PRODUCING CYCLIC SULFONIC ACID ESTER AND INTERMEDIATE THEREOF
  申请人：Kuramoto Ayako

  公开号：US20120130089A1

  公开（公告）日：2012-05-24

  The present invention is directed to provide an efficient production method which is capable of not only obtaining a cyclic sulfonic acid ester (sultone) at low cost and in high yield, but also the sulfonic acid ester (sultone) stably even in a commercial scale. The present invention relates to a method for producing hydroxysultone comprising a first step where a diol having a specified structure and a thionyl halide are reacted to obtain a cyclic sulfite having a specified structure, and a second step where the cyclic sulfite is reacted with water or/and alcohol; a method for producing an unsaturated sultone having a specified structure comprising a third step where a hydroxylsultone having a specified structure is reacted with an acid halide or an acid anhydride to obtain an intermediate, subsequently the intermediate is treated with a base; as well as a cyclic sulfite having a specified structure.

  本发明旨在提供一种高效的生产方法，该方法不仅能够以低成本和高产率获得环状磺酸酯（磺酮），而且能够在商业规模下稳定地生产磺酸酯（磺酮）。本发明涉及一种生产羟基磺酮的方法，包括第一步，其中将具有特定结构的二元醇和硫酰卤反应，以获得具有特定结构的环状亚磺酸酯，以及第二步，其中将环状亚磺酸酯与水或/和醇反应；一种生产具有特定结构的不饱和磺酮的方法，包括第三步，其中将具有特定结构的羟基磺酮与酸卤或酸酐反应，以获得中间体，随后用碱处理中间体；以及具有特定结构的环状亚磺酸酯。
• Intermediates for the synthesis of benzimidazole derivatives and a process for the preparation thereof
  申请人：SANKYO COMPANY, LIMITED

  公开号：US20030008907A1

  公开（公告）日：2003-01-09

  This invention provides a process for the preparation of a benzimidazole derivative (I) or a pharmaceutically acceptable salt thereof, 1 wherein R 1 is C 1 -C 6 alkyl, C 1 -C 6 alkoxyl, etc., R 2 is C 1 -C 6 alkyl, and R 3 is hydrogen or a protecting group, which exhibits excellent hyopoglycemic action, said process comprising condensation of an amine derivative (III) with a carboxylic acid derivatives (II) to afford a compound (IV), followed by cyclization of compound (IV) in the presence of an acid.

  本发明提供了一种制备苯并咪唑衍生物(I)或其药学上可接受的盐的方法，其中R1为C1-C6烷基，C1-C6烷氧基等，R2为C1-C6烷基，R3为氢或保护基，具有出色的降血糖作用，该方法包括将胺衍生物(III)与羧酸衍生物(II)缩合得到化合物(IV)，然后在酸的存在下使化合物(IV)环化。