N,N',P-triphenylphosphonothioic diamide | 18995-01-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N',P-triphenylphosphonothioic diamide
• 英文别名: phenyl-thiophosphonic acid-dianilide；Phenyl-thiophosphonsaeure-dianilid；N,N'-Diphenyl-phenyl-thiophosphonsaeurediamid；N-[anilino(phenyl)phosphinothioyl]aniline
• CAS: 18995-01-2
• 化学式: C₁₈H₁₇N₂PS
• 分子量: 324.386
• InChiKey: GZOIKJPNQRHEFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  56.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N,N',P-triphenylphosphonothioic diamide 反应 6.0h， 以58%的产率得到1,2,3,4-Tetraphenyl-2,4-dithio-cyclodiphosphazan
  参考文献：
  名称：

  Argent, Peter J.; Healy, James D.; Ibrahim, Ezzeldine H., Phosphorus and Sulfur and the Related Elements, 1981, vol. 12, p. 95 - 102

  摘要：

  DOI：
• 作为产物：
  描述：

  苯膦酰二氯 在 tetraphosphorus decasulfide 作用下， 生成 N,N',P-triphenylphosphonothioic diamide
  参考文献：
  名称：

  Prediction of Survival in Stage I Lung Carcinoma Patients by Telomerase Function Evaluation

  摘要：

  Telomerase activity and telomerase reverse transcriptase (hTERT) expression are elevated in human malignancies. We have investigated telomerase activity measured by the telomeric repeat amplification protocol (TRAP) assay and hTERT levels by real-time RT-PCR in stage I non-small-cell lung carcinomas. The purposes of our study included the comparison of these two techniques in the assessment of telomerase function and the evaluation of their prognostic significance. Telomerase activity and hTERT levels were determined in 90 stage I non-small-cell lung carcinoma patients, using TRAP assay and real-time RT-PCR, respectively. Variables were analyzed by the chi(2) and Fisher exact tests. Survival was analyzed by the Kaplan-Meier method. Multivariate analysis was performed with the Cox's proportional hazards model. Telomerase activity was elevated in 60 (67%) carcinomas. hTERT was elevated in 43 (48%) carcinomas. Only 21 (23%) tumors had low telomerase function by both TRAP and hTERT expression levels. Telomerase activity and hTERT were significantly correlated (p = 0.017), although 35 cases displayed discordant results. Both telomerase activity and hTERT levels were significantly associated with poor patient overall and disease-free survival (p = 0.019 and p = 0.018 for TRAP, and p = 0.011 and p = 0.012 for hTERT, respectively). Among the 21 patients with tumors displaying low telomerase function, defined by both TRAP and hTERT expression levels, only one succumbed to the disease (p = 0.0053). Our results suggest that the two techniques used in this study evaluate separate aspects of telomerase function and their combination provides powerful prognostic information in lung cancer patients.

  DOI：

  10.1097/01.lab.0000017165.26718.60

文献信息

• Thiadiazatrimethylenemethane and N,N′,P-triphenylphosphonothioic diamide complexes of platinum(<scp>II</scp>)
  作者：William Henderson、Raymond D. W. Kemmitt、Simon Mason、Mark R. Moore、John Fawcett、David R. Russell

  DOI：10.1039/dt9920000059

  日期：——

  Reaction of N,N'-diphenylthiourea with cis-[PtCl2L2] [L = PPh3, PMePh2, PMe2Ph, PEt2Ph, PPh2(NEt2) or L2 = Ph2PCH2CH2PPh2 (dppe) in the presence of silver(I) oxide gives the thiadiazatrimethylenemethane complexes [activated PtSC(=NPh)NPh}L2] an X-ray study on [activated PtSC(= NPh)NPh}(PPh3)2] establishing the presence of a flat activated Pt-S-C-N ring. Related activated Pt-S-P-N ring complexes which contain a reactive nucleophilic P = NPh group are formed upon treatment of PhNHP(S) (Ph)NHPh with cis-[PtCl2L2] [L = PPh3, L2 = dppe, Ph2P(CH2)3PPh2 or Ph2P(CH2)4PPh2] and potassium hydroxide. Treatment of [activated PtSP(= NPh)(Ph)NPh}L2] with Mel afforded an aminophosphonium salt, whilst with substrates containing either C = O or C = S functionalities new complexes of the type [activated [PtSPO(O)(Ph)NPh}L2] or [PtSP(S)(Ph)S}L2] were formed respectively.
• ARGENT P. J.; PARKER D.; SHAW R. A.; WOODS M., INORG. AND NUCL. CHEM. LETT., 1981, 17, NO 1-2, 11-14
  作者：ARGENT P. J.、 PARKER D.、 SHAW R. A.、 WOODS M.

  DOI：——

  日期：——
• Prediction of Survival in Stage I Lung Carcinoma Patients by Telomerase Function Evaluation
  作者：Antonio Marchetti、Caterina Pellegrini、Fiamma Buttitta、Monica Falleni、Solange Romagnoli、Lara Felicioni、Fabio Barassi、Simona Salvatore、Antonio Chella、Carlo Alberto Angeletti、Massimo Roncalli、Guido Coggi、Silvano Bosari

  DOI：10.1097/01.lab.0000017165.26718.60

  日期：2002.6

  Telomerase activity and telomerase reverse transcriptase (hTERT) expression are elevated in human malignancies. We have investigated telomerase activity measured by the telomeric repeat amplification protocol (TRAP) assay and hTERT levels by real-time RT-PCR in stage I non-small-cell lung carcinomas. The purposes of our study included the comparison of these two techniques in the assessment of telomerase function and the evaluation of their prognostic significance. Telomerase activity and hTERT levels were determined in 90 stage I non-small-cell lung carcinoma patients, using TRAP assay and real-time RT-PCR, respectively. Variables were analyzed by the chi(2) and Fisher exact tests. Survival was analyzed by the Kaplan-Meier method. Multivariate analysis was performed with the Cox's proportional hazards model. Telomerase activity was elevated in 60 (67%) carcinomas. hTERT was elevated in 43 (48%) carcinomas. Only 21 (23%) tumors had low telomerase function by both TRAP and hTERT expression levels. Telomerase activity and hTERT were significantly correlated (p = 0.017), although 35 cases displayed discordant results. Both telomerase activity and hTERT levels were significantly associated with poor patient overall and disease-free survival (p = 0.019 and p = 0.018 for TRAP, and p = 0.011 and p = 0.012 for hTERT, respectively). Among the 21 patients with tumors displaying low telomerase function, defined by both TRAP and hTERT expression levels, only one succumbed to the disease (p = 0.0053). Our results suggest that the two techniques used in this study evaluate separate aspects of telomerase function and their combination provides powerful prognostic information in lung cancer patients.
• Argent, Peter J.; Healy, James D.; Ibrahim, Ezzeldine H., Phosphorus and Sulfur and the Related Elements, 1981, vol. 12, p. 95 - 102
  作者：Argent, Peter J.、Healy, James D.、Ibrahim, Ezzeldine H.、Shaw, Robert A.、Woods, Michael

  DOI：——

  日期：——