5-isopropylidene-thiazolidine-2,4-dione | 5835-47-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 5-isopropylidene-thiazolidine-2,4-dione
• 英文别名: 5-Isopropyliden-thiazolidin-2,4-dion；5-propan-2-ylidene-1,3-thiazolidine-2,4-dione
• CAS: 5835-47-2
• 化学式: C₆H₇NO₂S
• mdl: MFCD07349360
• 分子量: 157.193
• InChiKey: QOWVABKYNPDNIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-isopropylidene-thiazolidine-2,4-dione 、 三氯硫氯甲烷 生成 5-isopropylidene-3-trichloromethanesulfenyl-thiazolidine-2,4-dione
  参考文献：
  名称：

  3-Trichloromethanesulfenyloxazolidine- and Thiazolidine-2,4-diones

  摘要：

  DOI：

  10.1021/ja01117a507
• 作为产物：
  描述：

  5-(1-methylethylidene)-2-thioxo-1,3-thiazolidin-4-one 在 双氧水 作用下， 生成 5-isopropylidene-thiazolidine-2,4-dione
  参考文献：
  名称：

  Taniyama et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1957, vol. 77, p. 1236,1239

  摘要：

  DOI：

文献信息

• Substituted Urea Depsipeptide Analogs as Activators of the CLPP Endopeptidase
  申请人：St. Jude Children's Research Hospital

  公开号：US20180079784A1

  公开（公告）日：2018-03-22

  In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators with the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of search in the particular art and is not intended to be limiting of the present invention.

  在一个方面，该发明涉及替代脲depsipeptide类似物，其衍生物以及相关化合物，这些化合物可作为ClpP内肽酶的激活剂；制备这些化合物的合成方法；包含这些化合物的药物组合物；以及使用这些化合物和组合物治疗传染病的方法。本摘要旨在作为特定领域搜索的扫描工具，并不意味着对本发明的限制。
• Dihydroindolone compounds, a process for their preparation and pharmaceutical compositions containing them
  申请人：Ortuno Jean-Claude

  公开号：US20110034460A1

  公开（公告）日：2011-02-10

  Compounds of formula (I): wherein: m and n represent 1 or 2, A represents a pyrrolyl group, X represents a C(O), S(O) or SO 2 group, R 1 and R 2 represent an alkyl group or, together with the nitrogen atom carrying them, form a heterocyclic group, R 3 and R 4 , together with the atoms carrying them, form a heterocyclic group, R 5 represents a hydrogen atom or an alkyl group, R 6 represents a hydrogen atom or a halogen atom. Medicinal products containing the same which are useful in treating cancer.

  式（I）的化合物： 其中： m和n代表1或2， A代表吡咯基， X代表C（O）、S（O）或SO2基团， R1和R2代表烷基或与携带它们的氮原子一起形成杂环基团， R3和R4与携带它们的原子一起形成杂环基团， R5代表氢原子或烷基， R6代表氢原子或卤素原子。 含有这些化合物的药物，可用于治疗癌症。
• NAPHTHYRIDINONE ANALOGS AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS
  申请人：Conn P. Jeffrey

  公开号：US20120172391A1

  公开（公告）日：2012-07-05

  In one aspect, the invention relates to naphthyridinone analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在一个方面，该发明涉及萘啉酮类似物，其衍生物和相关化合物，这些化合物可用作代谢型谷氨酸受体亚型5（mGluR5）的正向变构调节剂；制备这些化合物的合成方法；包括这些化合物的药物组合物；以及使用这些化合物和组合物治疗与谷氨酸功能障碍相关的神经和精神疾病的方法。本摘要旨在作为在特定领域进行搜索的扫描工具，并不打算限制本发明。
• SUBSTITUTED 6-ARYL-IMIDAZOPYRIDINE AND 6-ARYL-TRIAZOLOPYRIDINE CARBOXAMIDE ANALOGS AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR5
  申请人：Vanderbilt University

  公开号：US20160096833A1

  公开（公告）日：2016-04-07

  Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention

  本文披露了代谢型谷氨酸受体亚型5（mGluR5）的负向变构调节剂；制备这些化合物的合成方法；包含这些化合物的药物组合物；以及使用这些化合物和组合物治疗与谷氨酸功能障碍相关的神经和精神疾病的方法。本摘要旨在作为在特定领域进行搜索的扫描工具，并不旨在限制本发明。
• ALKYL 3-((2-AMIDOETHYL)AMINO)-8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE ANALOGS AS SELECTIVE M1 AGONISTS AND METHODS OF MAKING AND USING SAME
  申请人：Conn P. Jeffrey

  公开号：US20110172227A1

  公开（公告）日：2011-07-14

  In one aspect, the invention relates to compounds having a general structure: which are useful as selective allosteric or bitopic agonists of the M 1 muscarinic receptor; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurodegenerative diseases, including Alzheimer's Disease. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在一个方面，该发明涉及具有一般结构的化合物： 这些化合物可用作M1-肌胆碱受体的选择性变构或双拓扑激动剂；制备这些化合物的合成方法；包括这些化合物的药物组合物；以及使用这些化合物的方法，例如，在治疗神经退行性疾病，包括阿尔茨海默病。本摘要旨在作为在特定领域进行搜索的扫描工具，并不意味着对本发明的限制。

表征谱图