2-mesitylacetonitrile | 1314905-43-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-mesitylacetonitrile
• 英文别名: 2-(3,4,5-Trimethylphenyl)acetonitrile
• CAS: 1314905-43-5
• 化学式: C₁₁H₁₃N
• mdl: MFCD03428538
• 分子量: 159.231
• InChiKey: NGKBAGABSZXSLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-mesitylacetonitrile 在 正丁基锂 、 (S)-3,3'-bis(2,4,6-tri-iso-propylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate 、 二异丙胺 作用下， 以 四氢呋喃 、 甲醇 、 正己烷 、 甲苯 、 正戊烷 为溶剂， 反应 37.08h， 生成 (S)-2-mesitylpentanenitrile
  参考文献：
  名称：

  Catalytic Asymmetric Protonation of Silyl Ketene Imines

  摘要：

  An efficient catalytic and highly enantioselective protonation of silyl ketene imines is described. The reaction is catalyzed by the chiral phosphoric acids TRIP or STRIP in the presence of a stoichiometric amount of methanol as the proton source and silyl acceptor. A variety of substituted racemic silyl ketene imines have been transformed into highly enantioenriched nitriles.

  DOI：

  10.1021/ja312141b

文献信息

• Hiv inhibiting 1,2,4-triazines
  申请人：Lewi Joannes Paulus

  公开号：US20070037811A1

  公开（公告）日：2007-02-15

  The present invention relates to HIV replication inhibitors of formula (I) as defined in the specification their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them.
• US7585861B2
  申请人：——

  公开号：US7585861B2

  公开（公告）日：2009-09-08
• Catalytic Asymmetric Protonation of Silyl Ketene Imines
  作者：Joyram Guin、Georgy Varseev、Benjamin List

  DOI：10.1021/ja312141b

  日期：2013.2.13

  An efficient catalytic and highly enantioselective protonation of silyl ketene imines is described. The reaction is catalyzed by the chiral phosphoric acids TRIP or STRIP in the presence of a stoichiometric amount of methanol as the proton source and silyl acceptor. A variety of substituted racemic silyl ketene imines have been transformed into highly enantioenriched nitriles.