2-(甲基硫代)烟酸肼 | 232926-33-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-(甲基硫代)烟酸肼
• 英文名称: 2-Methylsulfanyl-nicotinic acid hydrazide
• 英文别名: 2-(Methylthio)nicotinic acid hydrazide；2-methylsulfanylpyridine-3-carbohydrazide
• CAS: 232926-33-9
• 化学式: C₇H₉N₃OS
• mdl: MFCD01310832
• 分子量: 183.234
• InChiKey: CYHNGINJLSMDNU-UHFFFAOYSA-N

物化性质

• 熔点：
  142-144°C

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  93.3
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi
• 危险类别码：
  R36/37/38
• 海关编码：
  2933399090
• 安全说明：
  S26,S36/37/39

反应信息

• 作为反应物：
  描述：

  甲醇 、 2-(甲基硫代)烟酸肼 在 ammonium cerium(IV) nitrate 作用下， 反应 0.75h， 以98%的产率得到methyl 2-methylthiopyridine-3-carboxylate
  参考文献：
  名称：

  Ceric(IV) ammonium nitrate in the selective conversion of hydrazides to esters

  摘要：

  Hydrazides were treated with ceric(IV) ammonium nitrate (CAN) in the presence of the appropriate alcohol as a nucleophile to afford esters in good yields. Reactions took place exclusively at the hydrazino moiety even when other sensitive groups were present in either of the partners. (C) 1999 Elsevier Science Ltd, All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00764-9

文献信息

• Ceric(IV) ammonium nitrate in the selective conversion of hydrazides to esters
  作者：Bogdan Štefane、Marijan Kočevar、Slovenko Polanc

  DOI：10.1016/s0040-4039(99)00764-9

  日期：1999.6

  Hydrazides were treated with ceric(IV) ammonium nitrate (CAN) in the presence of the appropriate alcohol as a nucleophile to afford esters in good yields. Reactions took place exclusively at the hydrazino moiety even when other sensitive groups were present in either of the partners. (C) 1999 Elsevier Science Ltd, All rights reserved.