2-(甲酰基氨基)-3-{5'-[2-(甲酰基氨基)-1-羟基乙基]-2',6-二羟基联苯基-3-基}-3-羟基丙酸(non-preferredname) | 128429-19-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-(甲酰基氨基)-3-{5'-[2-(甲酰基氨基)-1-羟基乙基]-2',6-二羟基联苯基-3-基}-3-羟基丙酸(non-preferredname)
• 英文名称: 2-Formamido-3-[3-[5-(2-formamido-1-hydroxyethyl)-2-hydroxyphenyl]-4-hydroxyphenyl]-3-hydroxypropanoic acid
• CAS: 128429-19-6
• 化学式: C₁₉H₂₀N₂O₈
• 分子量: 404.4
• InChiKey: WQVWUCSBLUJLNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  176
• 氢给体数：
  7
• 氢受体数：
  8

文献信息

• Remedies for vertebral canal stenosis
  申请人：Takenobu Yoshifumi

  公开号：US20060058310A1

  公开（公告）日：2006-03-16

  The present invention relates to a preventive and/or therapeutic agent for spinal canal stenosis comprising aldose reductase inhibitory compounds. A representative example of aldose reductase inhibitory compounds is the compound represented by formula (I): wherein all the symbols represent the same meaning as described in the specification; a salt of its acid when R 3a represents hydrogen, or solvate thereof The therapeutic agent of the present invention is effective for prevention and/or therapy for spinal canal stenosis and the like, such as lumbar spinal canal stenosis.