2-(o-tolylamino)acetamide | 191789-56-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(o-tolylamino)acetamide
• 英文别名: N-o-tolyl-glycine amide；o-Toluidinoessigsaeure-amid；N-o-Tolyl-glycin-amid；o-Toluidinoacetamid；2-(2-Methylanilino)acetamide
• CAS: 191789-56-7
• 化学式: C₉H₁₂N₂O
• mdl: MFCD11154372
• 分子量: 164.207
• InChiKey: PYDILTACCPFEFG-UHFFFAOYSA-N

物化性质

• 沸点：
  391.5±25.0 °C(Predicted)
• 密度：
  1.152±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(o-tolylamino)acetamide 在 alkali 作用下， 生成 N-苯基-N-甲基甘氨酸
  参考文献：
  名称：

  Silberstein, Chemische Berichte, 1884, vol. 17, p. 2661

  摘要：

  DOI：
• 作为产物：
  描述：

  [甲基(苯基)氨基]乙腈 在 硫酸 作用下， 生成 2-(o-tolylamino)acetamide
  参考文献：
  名称：

  Steppes, Journal fur praktische Chemie (Leipzig 1954), 1900, vol. <2> 62, p. 484

  摘要：

  DOI：

文献信息

• STUDIES ON ORGANOPHOSPHORUS HETERO-CYCLES PART IV. THE REACTION OF LAWESSON'S REAGENT WITH GLYCINAMIDES, SYNTHESIS AND HERBICIDAL ACTIVITY OF 1,3,2-DIAZAPHOS-PHOLIDIN-4-THIONE-2-SULFIDES
  作者：Liang Nian He、Ru-Yu Chen

  DOI：10.1080/10426509708031586

  日期：1997.10.1

  Abstract 2,4-Bis (4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide (Lawesson's Reagent) reacts with glycinamides (2a-m) in benzene at 55 ∼ 60°C to give 1,3,2-diazaphospholidin-4-thone-2-sulfides (3a-m). The structure of the products has been confirmed by elementary analyses, NMR, IR, MS and X-ray diffraction. The result of preliminary bioassay indicates that some of the compounds prepared

  摘要 2,4-双（4-甲氧基苯基）-1,3,2,4-二硫代二膦烷-2,4-二硫化物（Lawesson 试剂）与甘氨酰胺（2a-m）在苯中在 55 ∼ 60°C 下反应生成 1 ,3,2-diazaphospholidin-4-thone-2-sulfides (3a-m)。产物的结构已通过元素分析、核磁共振、红外、质谱和X射线衍射证实。初步生物测定结果表明，所制备的部分化合物对rap具有较高的选择性除草活性。
• BIARYL-SUBSTITUTED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S
  申请人：Allen Darin

  公开号：US20080207683A1

  公开（公告）日：2008-08-28

  Biaryl-substituted tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.

  所述的双芳基取代的四氢吡唑吡啶化合物被描述为对半胱氨酸蛋白酶S的调节剂。这些化合物可用于制备药物组合物和治疗由半胱氨酸蛋白酶S活性介导的疾病状态、疾病和病况的方法，如银屑病、疼痛、多发性硬化、动脉粥样硬化和类风湿性关节炎。
• METHOD FOR PREPARING OPTICALLY ACTIVE N-METHYLAMINO ACIDS AND OPTICALLY ACTIVE N-METHYLAMINO ACID AMIDES
  申请人：Arie Sachiko

  公开号：US20130041178A1

  公开（公告）日：2013-02-14

  The present invention relates to a method for preparing optically active N-methylamino acids and/or optically active N-methylamino acid amides by subjecting the cells or treatment products of a microorganism belonging to the Mycoplana genus to the hydrolysis with N-methylamino acid amide to give an optically active N-methylamino acid and an optically active N-methylamino acid amide. According to the present invention, optically active N-methylamino acids and optically active N-methylamino acid amides useful as the raw material of pharmaceuticals can be stereoselectively obtained with good efficiency.

  本发明涉及一种通过将属于Mycoplanagenus微生物的细胞或处理产物暴露于N-甲基氨基酸酰胺的水解作用，从而得到一种光学活性的N-甲基氨基酸和一种光学活性的N-甲基氨基酸酰胺的方法。根据本发明，可以高效地立体选择性地获得用作药物原料的光学活性N-甲基氨基酸和光学活性N-甲基氨基酸酰胺。
• Facile synthesis of 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones <i>via</i> cyclization of <i>N</i>-alkoxy α-halogenoacetamides with <i>N</i>-(2-chloromethyl)aryl amides
  作者：Qiaomei Jin、Dongjian Zhang、Jian Zhang

  DOI：10.1039/c9ob02260k

  日期：——

  A facile and efficient cyclization of N-alkoxy α-halogenoacetamides with N-(2-chloromethyl)aryl amides has been achieved for rapid access to 1,2,4,5-tetrahydro-1,4-benzodiazepine-3-one derivatives (up to 95% yield). The intriguing features of this intermolecular cyclization include its mild reaction conditions and easy handling for scalable synthesis.

  N-烷氧基α-卤代乙酰胺与N-（2-氯甲基）芳基酰胺的简便有效环合已实现，可快速获得1,2,4,5-四氢-1,4-苯并二氮杂-3-one衍生物（最高可达95％）。这种分子间环化的有趣特征包括其温和的反应条件和易于操作的可扩展合成。
• Polyfunctional imidazoles: I. Synthesis of 1-substituted 4-chloro-1H-imidazole-5-carbaldehydes by Vilsmeier-Haack reaction
  作者：V. A. Chornous、M. K. Bratenko、M. V. Vovk

  DOI：10.1134/s1070428009080168

  日期：2009.8

  2-[Alkyl(aryl)amino]acetamides in reaction with Vilsmeier-Haack reagent afforded 1-alkyl(aryl)-4-chloro-1H-imidazole-5-carbaldehydes.