4-(phenethylthio)phenol | 57401-02-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-(phenethylthio)phenol
• 英文别名: 4-(β-phenethylthio)phenol；4-(2-Phenylethylsulfanyl)phenol
• CAS: 57401-02-2
• 化学式: C₁₄H₁₄OS
• 分子量: 230.331
• InChiKey: JFNIDIDTWDBBFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(phenethylthio)phenol 、 氯化苄 生成 1-(2-Phenylethylsulfanyl)-4-phenylmethoxybenzene
  参考文献：
  名称：

  FUZUYA, XIROMI;TANIGUTI, KEHJDZI

  摘要：

  DOI：
• 作为产物：
  描述：

  4-羟基苯硫酚 、 甲磺酸苯乙酯 在 bis(1,5-cyclooctadiene)nickel (0) 、 四丁基醋酸铵 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 2.0h， 以91%的产率得到4-(phenethylthio)phenol
  参考文献：
  名称：

  预活化醇和酮的电化学脱氧硫醇化

  摘要：

  这项工作描述了一种电化学促进的镍催化的醇和酮在温和条件下的脱氧硫醇化反应。石墨烯/泡沫镍电极可以在未分割的电池中实现出色的基材耐受性和良好的化学产率。已经进行了进一步研究以获得对这种电化学交叉耦合的机械洞察力。

  DOI：

  10.1021/acs.orglett.1c02738

文献信息

• Mercapto phenolic and alkylthio phenolic antioxidants
  申请人：The Goodyear Tire & Rubber Company

  公开号：US04143076A1

  公开（公告）日：1979-03-06

  2-Mercapto phenol and/or 4-mercapto phenol are reacted with a compound selected from olefins, alcohols, and organic halides for example, styrene and isobutylene, to form (hydrocarbyl) thio phenolic antioxidants such as 2,6-di-tert. butyl-4-(tert.butylthio) phenol and 2,6-di(.alpha.-phenylethyl)-4-(.alpha.-phenylethylthio)phenol.

  2-巯基酚和/或4-巯基酚与来自烯烃、醇和有机卤化物的化合物发生反应，例如苯乙烯和异丁烯，形成（烃基）硫酚酚类抗氧化剂，例如2,6-二叔丁基-4-(叔丁硫基)酚和2,6-二(α-苯乙基)-4-(α-苯乙硫基)酚。
• Bioactive peptides
  申请人：ALPHARMA AS

  公开号：US20030022821A1

  公开（公告）日：2003-01-30

  The present invention provides a modified lactoferrin peptide which is cytotoxic, 7 to 25 amino acids in length, with three or more cationic residues and which has one or more extra bulky and lipophilic amino acids as compared to the native lactoferrin sequence, as well as esters, amides, salts and cyclic derivatives thereof as well as methods of preparing such peptides, pharmaceutical compositions containing such peptides and use of the peptides as medicaments, particularly as antibacterials or anti-tumoural agents.

  本发明提供一种改性乳铁蛋白肽，其具有细胞毒性，长度为7至25个氨基酸，含有三个或更多阳离子残基，并且与天然乳铁蛋白序列相比，具有一个或多个额外的笨重和亲脂氨基酸，以及其酯、酰胺、盐和环状衍生物，以及制备这些肽的方法、含有这些肽的药物组合物和将这些肽用作药物的用途，特别是作为抗菌或抗肿瘤剂。
• Inhibition of tumour growth
  申请人：Eliassen Tone Liv

  公开号：US20080019993A1

  公开（公告）日：2008-01-24

  The present invention provides a cytotoxic 7 to 25 mer peptide with three or more cationic residues which has one or more non-genetic bulky and lipophilic amino acids, as well as esters, amides, salts and cyclic derivatives thereof as well as methods of preparing the peptides, pharmaceutical compositions containing them and their use as medicaments, particularly as antibacterions or antitumoural agents. In a preferred aspect, the invention provides the use of said peptides in a method of inducing adaptive immunity against tumour growth or establishment in a subject, as well as the use of other lytic agents in a method of inducing adaptive immunity in a subject.

  本发明提供了一种细胞毒性的7至25个氨基酸残基的肽，其中含有三个或更多阳离子残基，其中含有一个或多个非遗传性的臃肿和亲脂性氨基酸，以及它们的酯类、酰胺、盐和环状衍生物，以及制备这些肽的方法、含有它们的药物组合物以及它们作为药物的用途，特别是作为抗菌或抗肿瘤剂。在一个优选方面，本发明提供了利用所述肽在主体中诱导适应性免疫反应以抑制肿瘤生长或建立的方法，以及利用其他溶解剂在主体中诱导适应性免疫反应的方法。
• INHIBITION OF TUMOR GROWTH
  申请人：Eliassen Liv Tone

  公开号：US20140037657A1

  公开（公告）日：2014-02-06

  The present invention provides a cytotoxic 7 to 25 mer peptide with three or more cationic residues which has one or more non-genetic bulky and lipophilic amino acids, as well as esters, amides, salts and cyclic derivatives thereof as well as methods of preparing the peptides, pharmaceutical compositions containing them and their use as medicaments, particularly as antibacterions or antitumoral agents. In a preferred aspect, the invention provides the use of said peptides in a method of inducing adaptive immunity against tumor growth or establishment in a subject, as well as the use of other lytic agents in a method of inducing adaptive immunity in a subject.

  本发明提供了一种具有三个或更多阳离子残基的细胞毒性7到25个氨基酸肽，其中具有一个或多个非遗传性臃肿和亲脂氨基酸，以及它们的酯，酰胺，盐和环状衍生物，以及制备肽的方法，含有它们的制药组合物以及它们作为药物的用途，特别是作为抗菌或抗肿瘤剂。在一个优选方面，本发明提供了在诱导受体中适应性免疫反应以抑制肿瘤生长或建立的方法中使用所述肽的用途，以及在诱导受体中适应性免疫反应的方法中使用其他溶解剂的用途。
• CURABLE COMPOSITION AND CURED OBJECT OBTAINED BY CURING SAME
  申请人：JXTG Nippon Oil & Energy Corporation

  公开号：EP3434709A1

  公开（公告）日：2019-01-30

  The present invention discloses a curable composition comprising: an epoxy compound represented by the following Formula (1); and one selected from the group consisting of: a thermal cationic polymerization initiator, an acid anhydride-based curing agent and a curing accelerator, and a photo-cationic polymerization initiator as well as the cured product therefrom. The above described curable composition is useful in that it allows for the production of a cured product having a high heat resistance. (In the Formula (1), A represents CR17R18; B represents CR19R20; R1 to R20 each independently represents a substituent selected from the group consisting of a hydrogen atom, an alkyl group and an alkoxy group; and n represents 0 or 1, with the proviso that when n is 0, m represents 1, and when n is 1, m represents 0.)

  本发明公开了一种可固化组合物，该组合物包括：由下式（1）表示的环氧化合物；和选自以下组别的一种：热阳离子聚合引发剂、酸酐基固化剂和固化促进剂、光阳离子聚合引发剂以及由此产生的固化产品。上述固化组合物的作用在于可以生产出具有高耐热性的固化产品。 (在式(1)中，A 代表 CR17R18；B 代表 CR19R20；R1 至 R20 各自独立地代表选自氢原子、烷基和烷氧基组成的组的取代基；n 代表 0 或 1，但条件是当 n 为 0 时，m 代表 1，而当 n 为 1 时，m 代表 0)。