2-(联苯基-2-基)-1-甲基咪唑 | 1046784-23-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(联苯基-2-基)-1-甲基咪唑
• 英文名称: 2-(biphenyl-2-yl)-1-methylimidazole
• 英文别名: 1-Methyl-2-(2-phenylphenyl)imidazole
• CAS: 1046784-23-9
• 化学式: C₁₆H₁₄N₂
• 分子量: 234.301
• InChiKey: IOBYYKCHQZDBRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-甲基-2-苯基-1H-咪唑 、 四苯硼钠 在 chloro(1,5-cyclooctadiene)rhodium(I) dimer potassium fluoride 、 氯乙酸乙酯 作用下， 以 邻二甲苯 为溶剂， 反应 6.0h， 以92%的产率得到2-(联苯基-2-基)-1-甲基咪唑
  参考文献：
  名称：

  Rhodium-catalyzed regioselective arylation of phenylazoles and related compounds with arylboron reagents via C–H bond cleavage

  摘要：

  The rhodium-catalyzed direct ortho-arylation reactions of phenylazoles using arylboron reagents such as tetraarylborates were examined. Ethyl chloroacetate and potassium fluoride were found to effectively act as a hydrogen acceptor and a promoter, respectively, to afford selective formation of the corresponding mono- or diarylated products with good yields. In addition, azobenzene as well as 2-phenylpyridine also underwent the direct arylation under similar conditions. (C) 2008 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2008.04.029

文献信息

• Ortho-selective Arylation of Arylazoles with Aryl Bromides Catalyzed by Ruthenium Complexes
  作者：Shuichi Oi、Hiromi Sasamoto、Raito Funayama、Yoshio Inoue

  DOI：10.1246/cl.2008.994

  日期：2008.9.5

  Ortho-selective direct arylation of arylazoles with aryl bromides has been accomplished in the presence of a catalytic amount of ruthenium complexes.

  在催化量的钌配合物存在下，芳基唑与芳基溴的邻位选择性直接芳基化已经完成。
• Rhodium-catalyzed regioselective arylation of phenylazoles and related compounds with arylboron reagents via C–H bond cleavage
  作者：Sawako Miyamura、Hayato Tsurugi、Tetsuya Satoh、Masahiro Miura

  DOI：10.1016/j.jorganchem.2008.04.029

  日期：2008.7

  The rhodium-catalyzed direct ortho-arylation reactions of phenylazoles using arylboron reagents such as tetraarylborates were examined. Ethyl chloroacetate and potassium fluoride were found to effectively act as a hydrogen acceptor and a promoter, respectively, to afford selective formation of the corresponding mono- or diarylated products with good yields. In addition, azobenzene as well as 2-phenylpyridine also underwent the direct arylation under similar conditions. (C) 2008 Elsevier B.V. All rights reserved.