4-furan-2-yl-7,8-dihydroxy-chromen-2-one | 1658-75-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 4-furan-2-yl-7,8-dihydroxy-chromen-2-one
• 英文别名: 4-<2>Furyl-daphnetin；4-(Furan-2-yl)-7,8-dihydroxychromen-2-one；4-(furan-2-yl)-7,8-dihydroxychromen-2-one
• CAS: 1658-75-9
• 化学式: C₁₃H₈O₅
• 分子量: 244.204
• InChiKey: NRBWITJAZXBQOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  79.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-(2-呋喃基)-3-氧代丙酸乙酯 、 邻苯三酚 在 氯化锆(IV) 作用下， 反应 0.17h， 以90%的产率得到4-furan-2-yl-7,8-dihydroxy-chromen-2-one
  参考文献：
  名称：

  An efficient ZrCl4 catalyzed one-pot solvent free protocol for the synthesis of 4-substituted coumarins

  摘要：

  A versatile and efficient route to 4-substituted cournarins via a Pechmann reaction using ZrCl4 as the catalyst (10 mol %) is described. This method provides several advantages over alternative procedures such as mild, solvent-free conditions at ambient temperature, and direct isolation of the products in high yields. (c) 2005 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2005.06.166

文献信息

• An efficient ZrCl4 catalyzed one-pot solvent free protocol for the synthesis of 4-substituted coumarins
  作者：G.V.M. Sharma、J. Janardhan Reddy、P. Sree Lakshmi、P. Radha Krishna

  DOI：10.1016/j.tetlet.2005.06.166

  日期：2005.9

  A versatile and efficient route to 4-substituted cournarins via a Pechmann reaction using ZrCl4 as the catalyst (10 mol %) is described. This method provides several advantages over alternative procedures such as mild, solvent-free conditions at ambient temperature, and direct isolation of the products in high yields. (c) 2005 Published by Elsevier Ltd.