2-(苯基硫羰基硫代)-2-苯基乙酸乙酯 | 1150308-13-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(苯基硫羰基硫代)-2-苯基乙酸乙酯
• 英文名称: ethyl 2-phenyl-2-((phenylcarbonothioyl)thio)acetate
• 英文别名: Ethyl 2-(phenylcarbonothioylthio)-2-phenylacetate；ethyl 2-(benzenecarbonothioylsulfanyl)-2-phenylacetate
• CAS: 1150308-13-6
• 化学式: C₁₇H₁₆O₂S₂
• 分子量: 316.445
• InChiKey: SQKNCNYHCGWDEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  83.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二硫化碳 、 苯基氯化镁 、 α-溴苯乙酸乙酯 以 四氢呋喃 为溶剂， 反应 12.08h， 以55%的产率得到2-(苯基硫羰基硫代)-2-苯基乙酸乙酯
  参考文献：
  名称：

  [EN] CONTINUOUS FLOW SYNTHESIS OF DITHIOESTER COMPOUNDS
  [FR] SYNTHÈSE EN ÉCOULEMENT CONTINU DE COMPOSÉS DITHIOESTER

  摘要：

  公开号：

  WO2014152453A3

文献信息

• [EN] BORONIC ESTER PRODRUGS AND USES THEREOF<br/>[FR] PROMÉDICAMENTS D'ESTER BORONIQUE ET LEURS UTILISATIONS
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2020236253A1

  公开（公告）日：2020-11-26

  Disclosed herein are compounds of Formula (I) or (II). The compounds include an agent (e.g., pharmaceutical agent, cosmetic agent, or nutraceutical agent) through a linker that includes a boronic ester moiety in the backbone of the linker. The compounds may be monomers. Also provided are polymers prepared by polymerizing the monomers. The polymers may be useful for delivering the agent to a subject, tissue, biological sample, or a cell. Also provided are methods of preparing the polymers, compositions and kits comprising the polymers, and methods of use (e.g., use in delivering the agent, treating a disease, preventing a disease, diagnosing a disease) involving the polymers or compositions. The structure of the boronic ester moiety may be fine tuned so that the properties related to delivery to a subject, biological sample, tissue, or cell may be fine tuned.

  本文披露了化合物的化学式(I)或(II)。这些化合物包括通过含有硼酸酯基团的连接剂（例如，药物剂、化妆品剂或营养剂）连接的活性物质。这些化合物可以是单体。还提供了通过聚合单体制备的聚合物。这些聚合物可能用于将活性物质传递给受试者、组织、生物样本或细胞。还提供了制备这些聚合物的方法、包含这些聚合物的组合物和试剂盒，以及涉及这些聚合物或组合物的使用方法（例如，用于传递活性物质、治疗疾病、预防疾病、诊断疾病）。硼酸酯基团的结构可以进行微调，以便微调与传递给受试者、生物样本、组织或细胞相关的性质。
• Polymeric prodrugs and subcutaneous and/or intramuscular administration thereof
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

  公开号：US20200353090A1

  公开（公告）日：2020-11-12

  The invention relates to new prodrugs of active molecules. These prodrugs allow, in particular, the subcutaneous or intramuscular administration of active molecules of which the subcutaneous or intramuscular administration is problematic or impossible, in particular because of the toxicity at the injection site. The prodrugs according to the invention comprise an active ingredient, covalently linked with a polymer chain, preferably a hydrophilic and/or thermosensitive polymer chain. The invention relates, in particular, to polymeric prodrugs comprising a polymer chain formed at least in part by acrylamide monomer or one of its derivatives, the polymer comprising a proximal part and a terminal part; a first pharmaceutically active molecule covalently coupled to the proximal part of the polymer; possibly a second pharmaceutically active molecule covalently coupled to the terminal part of the polymer.

  该发明涉及新型活性分子的前药。这些前药允许特别是将活性分子皮下或肌肉内注射，而这些活性分子的皮下或肌肉内注射由于在注射部位的毒性而具有问题或不可能，特别是由于在注射部位的毒性。根据本发明的前药包括一种活性成分，与一根聚合物链共价连接，优选为一种亲水性和/或热敏感性聚合物链。该发明特别涉及包括由丙烯酰胺单体或其衍生物之一至少部分形成的聚合物链的聚合物前药，该聚合物包括一个近端部分和一个末端部分；第一种药用活性分子共价结合到聚合物的近端部分；可能第二种药用活性分子共价结合到聚合物的末端部分。
• Polymerizable sulfonamide compounds and polymers thereof
  申请人：Massachusetts Institute of Technology

  公开号：US11155674B2

  公开（公告）日：2021-10-26

  Methods, compositions, reagents, and systems that allow for the preparation and utilization of sulfonamide salt polymer electrolytes are disclosed herein. Methods and reagents to prepare sulfonamide salt monomers are also disclosed herein. The sulfonamide salt polymer electrolytes can be used as components in energy storage devices, conductive materials, electrochemical cells, gels, adhesives, and drug delivery vehicles.

  本文公开了允许制备和利用磺胺盐聚合物电解质的方法、组合物、试剂和系统。本文还公开了制备磺胺盐单体的方法和试剂。磺胺盐聚合物电解质可用作能量存储设备、导电材料、电化学电池、凝胶、粘合剂和药物输送载体中的组件。
• IMPROVED CONTROLLED RADICAL POLYMERIZATION PROCESSES
  申请人：Matyjaszewski Krzysztof

  公开号：US20110046324A1

  公开（公告）日：2011-02-24

  A transition metal mediated chain transfer agent controlled polymerization process is described. The process combines the advantages of atom transfer radical polymerization (ATRP) and reversible addition fragmentation transfer (RAFT) polymerization. Synthesis of chain transfer agents useful in the disclosed processes is also disclosed. Other improvements on ATRP RAFT processes are also described.

  本文描述了一种过渡金属介导的链转移剂控制聚合过程。该过程结合了原子转移自由基聚合（ATRP）和可逆加成裂解转移（RAFT）聚合的优点。还公开了在所述过程中有用的链转移剂的合成方法。还描述了ATRP RAFT过程的其他改进。
• ACRYLIC COPOLYMER, PREPARATION METHOD THEREFOR, AND ACRYLIC COPOLYMER COMPOSITION COMPRISING SAME
  申请人：LG CHEM, LTD.

  公开号：EP3750928A1

  公开（公告）日：2020-12-16

  The present invention relates to an acrylic copolymer, and more particularly, to an acrylic copolymer including: a main monomer-derived repeating unit; and a chain transfer agent-derived part, wherein the main monomer-derived repeating unit includes a (meth)acrylic acid alkyl ester monomer-derived repeating unit, a (meth)acrylic acid alkoxy alkyl ester monomer-derived repeating unit, and a crosslinking monomer-derived repeating unit, the chain transfer agent-derived part is derived from a chain transfer agent having a carbonothioylthio group, and the chain transfer agent-derived part is included in an amount of 0.03 parts by weight to 0.08 parts by weight with respect to 100 parts by weight of the main monomer-derived repeating unit, a method of preparing the same, and an acrylic copolymer composition including the same.

  本发明涉及一种丙烯酸共聚物，更具体地说，涉及一种丙烯酸共聚物，包括其中主单体衍生的重复单元包括(甲基)丙烯酸烷基酯单体衍生的重复单元、(甲基)丙烯酸烷氧基烷基酯单体衍生的重复单元和交联单体衍生的重复单元，链转移剂衍生的部分由具有硫代碳酰基的链转移剂衍生，链转移剂衍生的部分以 0.以 100 份主单体衍生重复单元的重量计，链转移剂衍生部分的含量为 0.03 至 0.08 份（按重量计）；制备方法；以及包括上述内容的丙烯酸共聚物组合物。