3-[4-(3-[1,3]Dioxolan-2-yl-phenoxy)-phenyl]-propionic acid | 203510-51-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[4-(3-[1,3]Dioxolan-2-yl-phenoxy)-phenyl]-propionic acid
• 英文别名: 3-(4-(3-(1,3-Dioxolan-2-yl)phenoxy)phenyl)propanoic acid；3-[4-[3-(1,3-dioxolan-2-yl)phenoxy]phenyl]propanoic acid
• CAS: 203510-51-4
• 化学式: C₁₈H₁₈O₅
• 分子量: 314.338
• InChiKey: UEGXHLOSBVZIOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-[4-(3-[1,3]Dioxolan-2-yl-phenoxy)-phenyl]-propionic acid 在 盐酸 作用下， 以 丙酮 为溶剂， 反应 3.0h， 以100%的产率得到3-[4-(3-Formyl-phenoxy)-phenyl]-propionic acid
  参考文献：
  名称：

  Hapten Synthesis for a Monoclonal Antibody Based ELISA for Deltamethrin

  摘要：

  An enzyme-linked immunosorbent assay (ELISA) was developed for the insecticide deltamethrin. Two haptens were synthesized: the first one was a derivative of the whole molecule with a spacer arm bound to the aromatic ring; the second one was a derivative of deltamethric acid. Twelve monoclonal antibodies were obtained. A competitive ELISA using monoclonal antibody Del 01 yielded the most sensitive assay. The IC50 value for deltamethrin was estimated to be 0.5 mu g mL(-1) with a detection Limit of 0.08 mu g mL(-1). Monoclonal antibody Del 01 seems to be deltamethrin specific since <1% cross-reactivity with other pyrethroid analogues was observed.

  DOI：

  10.1021/jf9703922
• 作为产物：
  描述：

  对羟基苯丙酸甲酯 在 吡啶 、 氢氧化钾 、 sodium methylate 、 copper(l) chloride 作用下， 以 甲醇 为溶剂， 反应 20.0h， 生成 3-[4-(3-[1,3]Dioxolan-2-yl-phenoxy)-phenyl]-propionic acid
  参考文献：
  名称：

  Hapten Synthesis for a Monoclonal Antibody Based ELISA for Deltamethrin

  摘要：

  An enzyme-linked immunosorbent assay (ELISA) was developed for the insecticide deltamethrin. Two haptens were synthesized: the first one was a derivative of the whole molecule with a spacer arm bound to the aromatic ring; the second one was a derivative of deltamethric acid. Twelve monoclonal antibodies were obtained. A competitive ELISA using monoclonal antibody Del 01 yielded the most sensitive assay. The IC50 value for deltamethrin was estimated to be 0.5 mu g mL(-1) with a detection Limit of 0.08 mu g mL(-1). Monoclonal antibody Del 01 seems to be deltamethrin specific since <1% cross-reactivity with other pyrethroid analogues was observed.

  DOI：

  10.1021/jf9703922

文献信息

• Hapten Synthesis for a Monoclonal Antibody Based ELISA for Deltamethrin
  作者：Anne-Laurence Queffelec、Patrice Nodet、Jean-Pierre Haelters、Daniel Thouvenot、Bernard Corbel

  DOI：10.1021/jf9703922

  日期：1998.4.1

  An enzyme-linked immunosorbent assay (ELISA) was developed for the insecticide deltamethrin. Two haptens were synthesized: the first one was a derivative of the whole molecule with a spacer arm bound to the aromatic ring; the second one was a derivative of deltamethric acid. Twelve monoclonal antibodies were obtained. A competitive ELISA using monoclonal antibody Del 01 yielded the most sensitive assay. The IC50 value for deltamethrin was estimated to be 0.5 mu g mL(-1) with a detection Limit of 0.08 mu g mL(-1). Monoclonal antibody Del 01 seems to be deltamethrin specific since <1% cross-reactivity with other pyrethroid analogues was observed.