dichloro-bis-(2,4-dichloro-phenyl)-methane | 87596-30-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dichloro-bis-(2,4-dichloro-phenyl)-methane
• 英文别名: Dichlor-bis-(2,4-dichlor-phenyl)-methan；2,2',4,4'-tetrachloro-dichlorodiphenylmethane；2,4-Dichloro-1-[dichloro-(2,4-dichlorophenyl)methyl]benzene；2,4-dichloro-1-[dichloro-(2,4-dichlorophenyl)methyl]benzene
• CAS: 87596-30-3
• 化学式: C₁₃H₆Cl₆
• 分子量: 374.909
• InChiKey: NOLDZQGCGOETHO-UHFFFAOYSA-N

物化性质

• 沸点：
  445.8±40.0 °C(Predicted)
• 密度：
  1.560±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  dichloro-bis-(2,4-dichloro-phenyl)-methane 在 硫酸 、 溶剂黄146 作用下， 反应 1.0h， 生成 双(2,4-二氯苯基)甲酮
  参考文献：
  名称：

  1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, New Imidazoles with Potent Activity againstCandida albicansand Dermatophytes. Synthesis, Structure−Activity Relationship, and Molecular Modeling Studies

  摘要：

  New 1-[(3-aryloxy-3-aryl)propyl]-1H-imidazoles were synthesized and evaluated against Candida albicans and dermatophytes in order to develop structure-activity relationships (SARs). Against C. albicans the new imidazoles showed minimal inhibitory concentrations (MICs) comparable to those of ketoconazole, miconazole, and econazole, and were more potent than fluconazole. Several derivatives (10, 12, 14, 18-20, 24, 28, 29, 30, and 34) turned out to be potent inhibitors of C. albicans strains resistant to fluconazole, with MIC values less than 10 mu g/mL. Against dermatophytes strains, compounds 20, 25, and 33 (MIC <= 5 mu g/mL) were equipotent to ketoconazole, econazole, and miconazole. SARs of imidazoles 10-44 were rationalized with reasonable accuracy by a previously developed quantitative pharmacophore for antifungal agents.

  DOI：

  10.1021/jm800009r
• 作为产物：
  描述：

  四氯化碳 、 1,3-二氯苯 在 三氯化铝 作用下， 生成 dichloro-bis-(2,4-dichloro-phenyl)-methane
  参考文献：
  名称：

  FRIEDEL AND CRAFTS REACTION. II. THE CONDENSATION OF ortho- AND meta- DICHLOROBENZENE WITH CHLOROFORM AND CARBON TETRACHLORIDE

  摘要：

  DOI：

  10.1021/jo01209a001

文献信息

• [EN] NOVEL BENZODIOXOLES<br/>[FR] NOUVEAUX BENZODIOXOLES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2004013120A1

  公开（公告）日：2004-02-12

  The present invention relates to compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases, which are associated with the modulation of CB1 receptors.

  本发明涉及具有式（I）的化合物，其中R1、R2、R3、R4、R5、R6、R7和X如描述和权利要求中所定义，并且其药学上可接受的盐。这些化合物可用于治疗和/或预防与CB1受体调节相关的疾病。
• Benzodioxole derivatives
  申请人：Alanine Alexander

  公开号：US20050143373A1

  公开（公告）日：2005-06-30

  The present invention relates to compounds of the general formula and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases such as obesity by selective modulation of CB1 receptors.

  本发明涉及一般式的化合物及其药学上可接受的盐。该化合物通过选择性调节CB1受体，对于治疗和/或预防肥胖等疾病是有用的。
• NOVEL BENZODIOXOLES
  申请人：F.HOFFMANN-LA ROCHE AG

  公开号：EP1532132B1

  公开（公告）日：2008-03-19
• US6900227B2
  申请人：——

  公开号：US6900227B2

  公开（公告）日：2005-05-31
• US7576088B2
  申请人：——

  公开号：US7576088B2

  公开（公告）日：2009-08-18