2-(2,4-dinitro-phenyldisulfanyl)-5-phenyl-[1,3,4]thiadiazole | 1402734-76-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,4-dinitro-phenyldisulfanyl)-5-phenyl-[1,3,4]thiadiazole
• 英文别名: 2-[(2,4-Dinitrophenyl)disulfanyl]-5-phenyl-1,3,4-thiadiazole；2-[(2,4-dinitrophenyl)disulfanyl]-5-phenyl-1,3,4-thiadiazole
• CAS: 1402734-76-2
• 化学式: C₁₄H₈N₄O₄S₃
• 分子量: 392.44
• InChiKey: FMPSLSXROIFBOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  196
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  苯甲酰肼 在 potassium hydroxide 作用下， 以 乙醚 、 乙醇 为溶剂， 反应 18.5h， 生成 2-(2,4-dinitro-phenyldisulfanyl)-5-phenyl-[1,3,4]thiadiazole
  参考文献：
  名称：

  Synthesis and biological evaluation of nonsymmetrical aromatic disulfides as novel inhibitors of acetohydroxyacid synthase

  摘要：

  46 Novel nonsymmetrical aromatic disulfides containing [1,3,4] thiadiazole or [1,3,4] oxadiazole groups were synthesized and their biological activities were evaluated as inhibitors of acetohydroxyacid synthase (AHAS, EC 2.2.1.6). Besides their strong in vitro inhibition against plant AHAS, compounds 3e and 3f also display 80-100% post-emergence herbicidal activities in greenhouse bioassay at 1500 g/ha dosage. The assay of exogenous branched-chain amino acids supplementation on rape root growth of 3e suggests that the herbicidal activity has relationship with AHAS inhibition. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.05.013

文献信息

• Synthesis and biological evaluation of nonsymmetrical aromatic disulfides as novel inhibitors of acetohydroxyacid synthase
  作者：Zai-Shun Li、Wei-Min Wang、Wei Lu、Cong-Wei Niu、Yong-Hong Li、Zheng-Ming Li、Jian-Guo Wang

  DOI：10.1016/j.bmcl.2013.05.013

  日期：2013.7

  46 Novel nonsymmetrical aromatic disulfides containing [1,3,4] thiadiazole or [1,3,4] oxadiazole groups were synthesized and their biological activities were evaluated as inhibitors of acetohydroxyacid synthase (AHAS, EC 2.2.1.6). Besides their strong in vitro inhibition against plant AHAS, compounds 3e and 3f also display 80-100% post-emergence herbicidal activities in greenhouse bioassay at 1500 g/ha dosage. The assay of exogenous branched-chain amino acids supplementation on rape root growth of 3e suggests that the herbicidal activity has relationship with AHAS inhibition. (C) 2013 Elsevier Ltd. All rights reserved.